ChemicalBook > CAS DataBase List > N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Product Name
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
CAS No.
288159-40-0
Chemical Name
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
Synonyms
Boc-3-hydroxy-D-Valine;(R)-Boc-?-hydroxy-valine;Boc-3-Methyl-D-threonine;-2-((tert-Butoxycarbonyl);(R)-Boc-beta-hydroxy-valine;N-Boc-3-hydroxy-D-valine, 97%;(R)-Boc-beta, beta-dimethyl-serine;3-Hydroxy-D-valine, N-BOC protected;Boc-(R)-2-amino-3-methylbutanoic acid;(R)-Boc-2-aMino-3-hydroxy-3-Methyl-butyric acid
CBNumber
CB0233866
Molecular Formula
C10H19NO5
Formula Weight
233.26
MOL File
288159-40-0.mol
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N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Property

Boiling point:
391.1±37.0 °C(Predicted)
Density 
1.175±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.62±0.10(Predicted)
InChI
InChI=1S/C10H19NO5/c1-9(2,3)16-8(14)11-6(7(12)13)10(4,5)15/h6,15H,1-5H3,(H,11,14)(H,12,13)/t6-/m0/s1
InChIKey
SZVRVSZFEDIMFM-LURJTMIESA-N
SMILES
C(O)(=O)[C@@H]([C@@](C)(O)C)NC(OC(C)(C)C)=O
CAS DataBase Reference
288159-40-0
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Safety

HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB55458
Product name
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging
25mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55458
Product name
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging
50mg
Price
$102.5
Updated
2021/12/16
Chem-Impex
Product number
28640
Product name
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid,98%(Chiralpurity)
Purity
98%(Chiralpurity)
Packaging
100MG
Price
$106.4
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55458
Product name
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging
100mg
Price
$164
Updated
2021/12/16
Matrix Scientific
Product number
042074
Product name
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging
100mg
Price
$179
Updated
2021/12/16
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N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

182958-73-2

288159-40-0

General procedure for the synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid from tert-butyl (S)-(1,3-dihydroxy-3-methylbutan-2-yl)carbamate: [Step 3] Synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid: at -35 °C, an aqueous solution of sodium hypochlorite (5.0 mL, containing 0.8 g, 0.64 mmol) and aqueous sodium hypochlorite (10 mL, containing 2.4 g, 27 mmol) were added simultaneously and slowly to an acetonitrile containing Reference Example Compound 36 (2.8 g, 13 mmol), 2,2,6,6-tetramethylpiperidinium 1-yloxy (0.40 g, 2.6 mmol), and a standard neutral phosphate buffer (45 mL) (50 mL) solution. The reaction solution was stirred at -35 °C for 3 h. Acetic acid (1.0 mL) was added. Stirring was continued at -35°C for 3 hours, followed by the addition of water and extraction with ethyl acetate. The organic layer was washed sequentially with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was dissolved in saturated aqueous sodium bicarbonate solution and washed with ethyl acetate. The aqueous layer was acidified with 3N hydrochloric acid and extracted again with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.5 g (84% yield) of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid (hereinafter referred to as Reference Example Compound 37).

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 1, p. 177 - 179
[2] Nature Chemistry, 2010, vol. 2, # 4, p. 280 - 285
[3] Patent: EP2832724, 2015, A1. Location in patent: Paragraph 0188

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID manufacturers

Career Henan Chemical Co
Product
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID 288159-40-0
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-09

288159-40-0, N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACIDRelated Search:

BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID,N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID allo-DL-Threonine N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID BOC-D-THR-OH D-beta-Hydroxyvaline (R)-2-Amino-3-hydroxy-3-methylbutanoic acid BOC-(RS)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID D(-)-allo-Threonine Boc-D-Serine

  • BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
  • (R)-Boc-2-aMino-3-hydroxy-3-Methyl-butyric acid
  • (R)-Boc-beta-hydroxy-valine
  • N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
  • Boc-(R)-2-amino-3-methylbutanoic acid
  • (R)-Boc-beta, beta-dimethyl-serine
  • N-Boc-3-hydroxy-D-valine, 97%
  • 3-Hydroxy-D-valine, N-BOC protected
  • N-(tert-Butoxycarbonyl)-3-hydroxy-D-valine, (2R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-3-methylbutanoic acid
  • -2-((tert-Butoxycarbonyl)
  • (R)-Boc-?-hydroxy-valine
  • Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid≥ 99% (HPLC)
  • (2R)-3-hydroxy-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
  • D-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-
  • (2R)-3-hydroxy-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoicaci
  • N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID USP/EP/BP
  • Boc-3-hydroxy-D-Valine
  • (R)-2-(Boc-amino)-3-hydroxy-3-methylbutanoic Acid
  • Boc-3-Methyl-D-threonine
  • 288159-40-0
  • unnatural amino acids