Boc-D-Serine

Product Name: Boc-D-Serine
CAS No.: 6368-20-3
Chemical Name: Boc-D-Serine
Synonyms: (tert-Butoxycarbonyl)-D-serine;BOC-D-SER-OH;Boc-D-Ser;N-BOC-D-SERINE;OC-D-Serine;BOC-D-SERINE;BOC-D-SERINE H2O;N-T-BOC-D-SERINE;BOC-D-Serine,98%;Bok - D - serine
CBNumber: CB0718613
Molecular Formula: C8H15NO5
Formula Weight: 205.21
MOL File: 6368-20-3.mol

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Boc-D-Serine Property

Melting point:: 91-95 °C(lit.)
alpha: 8.5 º (c=1 H2O)
Boiling point:: 343.88°C (rough estimate)
Density: 1.2977 (rough estimate)
refractive index: 1.4540 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.62±0.10(Predicted)
color: White
optical activity: 13.09°(C=0.4243g/100mI, DMF, 20°C, 589nm)
Water Solubility: almost transparency
BRN: 1874714
InChI: InChI=1S/C8H15NO5/c1-8(2,3)14-7(13)9-5(4-10)6(11)12/h5,10H,4H2,1-3H3,(H,9,13)(H,11,12)/t5-/m1/s1
InChIKey: FHOAKXBXYSJBGX-RXMQYKEDSA-N
SMILES: C(O)(=O)[C@@H](CO)NC(OC(C)(C)C)=O
CAS DataBase Reference: 6368-20-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53096
Product name: Boc-D-Ser-OH
Purity: Novabiochem?
Packaging: 25g
Price: $517
Updated: 2025/07/31

TCI Chemical

Product number: B2258
Product name: N-(tert-Butoxycarbonyl)-D-serine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B2258
Product name: N-(tert-Butoxycarbonyl)-D-serine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TRC

Product number: B667350
Product name: Boc-D-serine
Packaging: 10g
Price: $375
Updated: 2021/12/16

Usbiological

Product number: 264186
Product name: BOC-D-Ser-OH
Packaging: 5g
Price: $382
Updated: 2021/12/16

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Boc-D-Serine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-D-serine is D-serine (S270975) with amine protected from eletrophiles by tert-butyloxycarbonyl group in organic synthesis. Boc-D-serine can be used to synthesize acetamido-methoxypropionamides such as Desacetyl Desmethyl Lacosamide (D288325) which is a potent anticonvulsant.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

312-84-5

24424-99-5

3262-72-4

1. An aqueous solution of sodium hydroxide (8.4 g, 0.110 mol) was prepared by dissolving sodium hydroxide (8.4 g, 0.110 mol) in water (53 mL) at room temperature. 2. The above solution was cooled down to 5-10 °C. 3. To the cooled aqueous solution of sodium hydroxide was added sequentially D-serine (10.5 g, 0.100 mol) and di-tert-butyl dicarbonate (26.2 g, 0.120 mol), while the temperature was maintained at ≤ 10 °C. 4. 26.2 g, 0.120 mol). 4. The reaction mixture was heated to 30-35 °C and stirred at this temperature for 20 h. 5. Upon completion of the reaction, an aqueous solution of compound I (BOC-L-serine) was obtained in 100% yield, with 99.1% HPLC purity and 99.4% chiral purity. 6. The aqueous solution of compound I did not need to be further purified and could be used directly in the subsequent synthetic step. 7. The aqueous solution of compound I can be used directly in the subsequent synthesis steps.

References

[1] Journal of the American Chemical Society, 1994, vol. 116, # 18, p. 8402 - 8403
[2] Journal of the American Chemical Society, 2008, vol. 130, # 7, p. 2351 - 2364
[3] Advanced Synthesis and Catalysis, 2016, vol. 358, # 1, p. 34 - 40
[4] Patent: CN104030943, 2016, B. Location in patent: Paragraph 0095; 0096
[5] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 1114 - 1120

Boc-D-Serine Preparation Products And Raw materials

Raw materials

Preparation Products

BOC-3-IODO-D-ALANINE BENZYL ESTER

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Boc-D-Serine Suppliers

Americas 1 Belgium 1 China 317 Europe 2 France 3 Germany 7 Hungary 2 India 47 Japan 7 Switzerland 5 United Kingdom 7 United States 58 Global 457

Shanghai Chiral Chemicals Inc.

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Alfa Aesar

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Sichuan Tongsheng Amino acids Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Energy Chemical

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GL Biochem (Shanghai) Ltd

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Capot Chemical Co., Ltd

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View Lastest Price from Boc-D-Serine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-D-Serine 6368-20-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Henan Fengda Chemical Co., Ltd

Product: Boc-D-Serine 6368-20-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Boc-D-Serine 6368-20-3
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-07-31

6368-20-3, Boc-D-SerineRelated Search:

D-Cycloserine N-Carbobenzyloxyglycine L-CYCLOSERINE tert-Butanol L-Homoserine L-Serine L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE D-Serine DL-Serine L-Valine methyl ester hydrochloride D-Valine N-BOC-O-Benzyl-L-serine DIETHYL (BOC-AMINO)MALONATE DIMETHYL (BOC-AMINO)MALONATE N-(tert-Butoxycarbonyl)-O-benzyl-D-threonine BOC-D-THR-OH BOC-D-SERINE METHYL ESTER,BOC-D-SERINE METHYLESTER OIL,N-BOC-D-serine methylester Boc-Ser(tBu)-OH

BOC-D-SERINE H2O

BOC-D-SER-OH

BOC-D-SERINE

N-(TERT-BUTOXYCARBONYL)-D-SERIN

N-(TERT-BUTOXYCARBONYL)-D-SERINE

N-T-BOC-D-SERINE

N-ALPHA-T-BUTOXYCARBONYL-D-SERINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-D-SERINE

N-ALPHA-T-BOC-D-SERINE

N-BOC-D-SERINE

D-Serine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)

OC-D-Serine

N-ALPHA-T-BUTYLOXYCARBONYL-D-SERINE

Boc-D-Serine (amhydrons)

N-Boc-D-serine, 98+%

(tert-Butoxycarbonyl)-D-serine

(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxypropanoic acid

BOC-D-SERINE extrapure

N-(tert-Butoxycarbonyl)-D-serine, N-t-Boc-D-Serine, Boc-D-Ser-OH

(R)-2-[(tert-Butyloxycarbonyl)amino]-3-hydroxypropanoic acid

N-(tert-Butyloxycarbonyl)-D-serine

BOC-D-Serine,98%

Boc-D-Ser

(R)-Boc-2-amino-3-hydroxypropionic acid

Boc-D-serine≥ 99% (HPLC)

Boc-D-β-hydroxyalanine

N-Boc-D-serine,99%e.e.

(Tert-Butoxy)Carbonyl D-Ser-OH

N-Boc-D-serine Boc-D-Ser-OH

Boc-D-Ser-OH (Boc-D-Serine)

D-Serine,N-[(1,1-diMethylethoxy)carbonyl]-

Boc-D-Ser-OH >=98.0% (TLC)

Boc-D-Ser-OH monohydrate

(R)-tert-Butoxycarbonyl-D-Serine

N-Boc-D-serine,Lacosamide

N-(tert-Butoxycarbonyl)-D-serine &gt

(2R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoicaci

Bok - D - serine

N-(tert-Butoxycarbonyl)-D-serineN-

N-[(1,1-Dimethylethoxy)carbonyl]-D-serine

(R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid

Boc-<sc>D</sc>-Ser-OH

6368-20-3

HOCH2CHNHCO2CCH33CO2H

C8H14NO5

CARBOXYLIC ACID

Amino Acid Derivatives

Peptide Synthesis

Serine

Specialty Synthesis

Boc-Amino Acids

Protected & Labeled Amino Acids

Amino Acids (N-Protected)

Boc-Amino Acids and Derivative

AMINOACIDS DERIVATIVES

Amino Acids

N-BOC

Amino Acids (N-Protected)