1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
- Product Name
- 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
- CAS No.
- 51843-24-4
- Chemical Name
- 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
- Synonyms
- 3-ACETYL-5-CHLOROINDOLE;5-chloro-3-acetyl-indole;5-chloro-3-indolyl -ethanone;1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE;Ethanone, 1-(5-chloro-1H-indol-3-yl)-;1-(5-chloro-1H-indol-3-yl)ethan-1-one
- CBNumber
- CB0236074
- Molecular Formula
- C10H8ClNO
- Formula Weight
- 193.63
- MOL File
- 51843-24-4.mol
1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Property
- Melting point:
- 168 °C (decomp)(Solv: ethyl ether (60-29-7))
- Boiling point:
- 367.9±22.0 °C(Predicted)
- Density
- 1.332
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 14.46±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368950
- Product name
- 1-(5-Chloro-1H-indol-3-yl)ethanone
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- C368950
- Product name
- 1-(5-Chloro-1H-indol-3-yl)ethanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC32873
- Product name
- 1-(5-Chloro-1H-indol-3-yl)ethanone
- Packaging
- 100mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- FC32873
- Product name
- 1-(5-Chloro-1H-indol-3-yl)ethanone
- Packaging
- 500mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- OR913238
- Product name
- 1-(5-Chloro-1H-indol-3-yl)ethanone
- Purity
- 95%
- Packaging
- 250mg
- Price
- $247
- Updated
- 2021/12/16
1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Chemical Properties,Usage,Production
Synthesis
17422-32-1
108-24-7
51843-24-4
The general procedure for the synthesis of 5-chloro-3-indoleacetophenone from 5-chloroindole and ethanoic anhydride: 1 mmol of 5-chloroindole, 1 mmol of ethanoic anhydride, 0.01 mmol of metal salt catalyst of trifluoromethanesulfonic acid, and 1 mmol of ionic liquid were sequentially added to a 10 mL glass reaction tube suitable for single mode microwave reaction. Subsequently, the reaction tube was sealed with a polytetrafluoroethylene cap and placed in a single-mode microwave reactor, and the microwave radiation reaction was carried out under different temperature and time conditions to optimize the reaction conditions. After completion of the reaction, the reaction tube was cooled to room temperature and the reaction mixture was extracted with ether (5 × 10 mL). The ether layer was separated and washed with deionized water (2 × 10 mL), saturated aqueous sodium bicarbonate solution (2 × 20 mL) and saturated saline (2 × 10 mL) sequentially. The organic phase was dried over anhydrous magnesium sulfate and filtered, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, n-hexane/ethyl acetate, gradient elution ratio from 10:0 to 8:2) to obtain the target product 5-chloro-3-indoleacetophenone, and the isolated yield was calculated.
References
[1] RSC Advances, 2017, vol. 7, # 86, p. 54399 - 54406
[2] Molecules, 2015, vol. 20, # 10, p. 19605 - 19619
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 15, p. 3184 - 3194
[4] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[5] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 793 - 801
1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE manufacturers
- Product
- 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE 51843-24-4
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09