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1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE

Product Name
1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
CAS No.
51843-24-4
Chemical Name
1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
Synonyms
3-ACETYL-5-CHLOROINDOLE;5-chloro-3-acetyl-indole;5-chloro-3-indolyl -ethanone;1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE;Ethanone, 1-(5-chloro-1H-indol-3-yl)-;1-(5-chloro-1H-indol-3-yl)ethan-1-one
CBNumber
CB0236074
Molecular Formula
C10H8ClNO
Formula Weight
193.63
MOL File
51843-24-4.mol
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1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Property

Melting point:
168 °C (decomp)(Solv: ethyl ether (60-29-7))
Boiling point:
367.9±22.0 °C(Predicted)
Density 
1.332
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
14.46±0.30(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368950
Product name
1-(5-Chloro-1H-indol-3-yl)ethanone
Packaging
500mg
Price
$110
Updated
2021/12/16
TRC
Product number
C368950
Product name
1-(5-Chloro-1H-indol-3-yl)ethanone
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC32873
Product name
1-(5-Chloro-1H-indol-3-yl)ethanone
Packaging
100mg
Price
$74
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC32873
Product name
1-(5-Chloro-1H-indol-3-yl)ethanone
Packaging
500mg
Price
$185
Updated
2021/12/16
Apolloscientific
Product number
OR913238
Product name
1-(5-Chloro-1H-indol-3-yl)ethanone
Purity
95%
Packaging
250mg
Price
$247
Updated
2021/12/16
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1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Chemical Properties,Usage,Production

Synthesis

17422-32-1

108-24-7

51843-24-4

The general procedure for the synthesis of 5-chloro-3-indoleacetophenone from 5-chloroindole and ethanoic anhydride: 1 mmol of 5-chloroindole, 1 mmol of ethanoic anhydride, 0.01 mmol of metal salt catalyst of trifluoromethanesulfonic acid, and 1 mmol of ionic liquid were sequentially added to a 10 mL glass reaction tube suitable for single mode microwave reaction. Subsequently, the reaction tube was sealed with a polytetrafluoroethylene cap and placed in a single-mode microwave reactor, and the microwave radiation reaction was carried out under different temperature and time conditions to optimize the reaction conditions. After completion of the reaction, the reaction tube was cooled to room temperature and the reaction mixture was extracted with ether (5 × 10 mL). The ether layer was separated and washed with deionized water (2 × 10 mL), saturated aqueous sodium bicarbonate solution (2 × 20 mL) and saturated saline (2 × 10 mL) sequentially. The organic phase was dried over anhydrous magnesium sulfate and filtered, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, n-hexane/ethyl acetate, gradient elution ratio from 10:0 to 8:2) to obtain the target product 5-chloro-3-indoleacetophenone, and the isolated yield was calculated.

References

[1] RSC Advances, 2017, vol. 7, # 86, p. 54399 - 54406
[2] Molecules, 2015, vol. 20, # 10, p. 19605 - 19619
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 15, p. 3184 - 3194
[4] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[5] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 793 - 801

1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE Suppliers

China 58 Germany 1 India 2 Switzerland 1 United Kingdom 2 United States 6 Global 70
Achemica
Tel
--
Fax
--
Email
contact@achemica.com
Country
Switzerland
ProdList
6155
Advantage
50
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View Lastest Price from 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE manufacturers

Career Henan Chemical Co
Product
1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE 51843-24-4
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

51843-24-4, 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONERelated Search:

Hydrochlorothiazide 2-CHLORO-1-(5-CHLORO-1H-INDOL-3-YL)-ETHANONE 6-chloro-2,2-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-one methyl 2-(5-chloro-1H-indol-3-yl)-2-oxoacetate 1-(2-BROMO-5,6-DICHLORO-1H-INDOL-3-YL)ETHANONE 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE 2-BROMO-1-(5-CHLORO-2-METHYL-1H-INDOL-3-YL)-PROPAN-1-ONE 1-(2,5,6-TRICHLORO-1H-INDOL-3-YL)ETHANONE 2-BROMO-1-(5-CHLORO-1H-INDOL-3-YL)-PROPAN-1-ONE 2-CHLORO-1-(5-CHLORO-2-METHYL-1H-INDOL-3-YL)-ETHANONE

  • 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
  • 3-ACETYL-5-CHLOROINDOLE
  • 1-(5-chloro-1H-indol-3-yl)ethan-1-one
  • 5-chloro-3-acetyl-indole
  • 5-chloro-3-indolyl -ethanone
  • Ethanone, 1-(5-chloro-1H-indol-3-yl)-
  • 51843-24-4
  • Indole