ChemicalBook > CAS DataBase List > ETHYL 4-METHOXYBENZOYLACETATE

ETHYL 4-METHOXYBENZOYLACETATE

Product Name
ETHYL 4-METHOXYBENZOYLACETATE
CAS No.
2881-83-6
Chemical Name
ETHYL 4-METHOXYBENZOYLACETATE
Synonyms
MOBEE;AKOS 228-23;BUTTPARK 18\10-44;ETHYL P-ANISOYLACETATE;ETHYL 4-METHOXYBENZOYLACETATE;Ethyl p-methoxybenzoyl acetate;Ethyl4-Methoxybenzoylacetate>P-ANISOYLACETIC ACID ETHYL ESTER;Acetic acid, p-anisoyl-, ethyl ester;4-METHOXYBENZOYLACETIC ACID ETHYL ESTER
CBNumber
CB0240202
Molecular Formula
C12H14O4
Formula Weight
222.24
MOL File
2881-83-6.mol
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ETHYL 4-METHOXYBENZOYLACETATE Property

Boiling point:
154 °C1 hPa(lit.)
Density 
1.160 g/mL at 20 °C(lit.)
refractive index 
1.5410 to 1.5460
Flash point:
115°C
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: soluble
form 
clear liquid
pka
10.34±0.25(Predicted)
color 
Light yellow to Yellow to Orange
InChI
InChI=1S/C12H14O4/c1-3-16-12(14)8-11(13)9-4-6-10(15-2)7-5-9/h4-7H,3,8H2,1-2H3
InChIKey
KRAHENMBSVAAHD-UHFFFAOYSA-N
SMILES
C1(=CC=C(OC)C=C1)C(=O)CC(=O)OCC
CAS DataBase Reference
2881-83-6(CAS DataBase Reference)
EPA Substance Registry System
Benzenepropanoic acid, 4-methoxy-.beta.-oxo-, ethyl ester (2881-83-6)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
2918.99.4700
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M1380
Product name
Ethyl (4-Methoxybenzoyl)acetate
Packaging
5G
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
M1380
Product name
Ethyl (4-Methoxybenzoyl)acetate
Purity
>97.0%(GC)
Packaging
25g
Price
$137
Updated
2025/07/31
Matrix Scientific
Product number
080147
Product name
Ethyl 3-(4-methoxyphenyl)-3-oxopropanoate
Packaging
5g
Price
$38
Updated
2021/12/16
Matrix Scientific
Product number
080147
Product name
Ethyl 3-(4-methoxyphenyl)-3-oxopropanoate
Packaging
25g
Price
$115
Updated
2021/12/16
AK Scientific
Product number
J55409
Product name
Ethyl (4-Methoxybenzoyl)acetate
Packaging
500g
Price
$1280
Updated
2021/12/16
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ETHYL 4-METHOXYBENZOYLACETATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 4207, 1973 DOI: 10.1016/S0040-4039(01)87150-1
Synthesis, p. 290, 1993 DOI: 10.1055/s-1993-25849

Synthesis

100-06-1

105-58-8

2881-83-6

To a stirred mixture of sodium hydride (3 mol eq.) and diethyl carbonate (4 mol eq.) in 50 mL of tetrahydrofuran (THF) washed with hexane (3 x 15 mL), p-methoxyacetophenone (1 mol eq.) was slowly added dropwise for a controlled period of 30 min or more. The reaction mixture was heated and refluxed for 3-4 h until the color of the reaction solution changed to dark brown and the reaction progress was monitored by thin layer chromatography (TLC, unfolding agent 10% ethyl acetate/hexane). Upon completion of the reaction, the mixture was cooled to room temperature and acidified with 5 mL of glacial acetic acid, followed by the addition of 100 mL of ice-cold dilute hydrochloric acid solution. The aqueous phase was extracted with ethyl acetate (3 x 75 mL) and the organic phases were combined and washed sequentially with saturated sodium bicarbonate solution, saturated saline and deionized water. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 3-(4-methoxyphenyl)-3-oxopropanoate as a viscous substance in good yield. The structure of the product was confirmed by 1H NMR and 13C NMR spectroscopy and the data were in agreement with literature reports.

References

[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 31, p. 4543 - 4547
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 14, p. 4237 - 4244
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 34, p. 8661 - 8664
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[5] European Journal of Organic Chemistry, 2012, # 35, p. 6976 - 6985

ETHYL 4-METHOXYBENZOYLACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-METHOXYBENZOYLACETATE Suppliers

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View Lastest Price from ETHYL 4-METHOXYBENZOYLACETATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
ETHYL 4-METHOXYBENZOYLACETATE 2881-83-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl (4-Methoxybenzoyl)acetate 2881-83-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
ETHYL 4-METHOXYBENZOYLACETATE 2881-83-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

2881-83-6, ETHYL 4-METHOXYBENZOYLACETATERelated Search:

Ethyl 3,4,5-trimethoxybenzoylacetate ETHYL 4-METHOXYBENZOYLACETATE Quincarbate PHENOXYACETIC ACID Ethyl benzoylacetate 3-BENZO[1,3]DIOXOL-5-YL-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(2-HYDROXY-4-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-OXO-3-(4-PHENOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER 3-(4-METHOXY-PHENYL)-2,3-DIOXO-PROPIONIC ACID TERT-BUTYL ESTER BETA-OXO-4-(PHENYLMETHOXY)-BENZENEPROPANOIC ACID ETHYL ESTER 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(2,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2-(4-NITRO-PHENYL)-3-OXO-3-(2,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER AURORA 17731 diethyl (3,4,5-trimethoxybenzoyl)malonate ETHYL 4-OXO-7-(BENZYLOXY)HYDROQUINOLINE-3-CARBOXYLATE AURORA 17732 3-(2,4-DIMETHOXY-PHENYL)-2-(4-NITRO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

  • 3-keto-3-(4-methoxyphenyl)propionic acid ethyl ester
  • p-Anisoylacetic Acid Ethyl Ester Ethyl p-Anisoylacetate 4-Methoxybenzoylacetic Acid Ethyl Ester
  • 3-(4-Methoxy-phenyl)-3-oxo-propionic acid ethyl ester
  • 2-(p-Methoxybenzoyl)acetic acid ethyl ester
  • 3-(4-methoxyphenyl)-3-oxopropanoic acid ethyl ester
  • Acetic acid, p-anisoyl-, ethyl ester
  • P-ANISOYLACETIC ACID ETHYL ESTER
  • MOBEE
  • 4-methoxy-beta-oxo-benzenepropanoicaciethylester
  • Benzenepropanoic acid, 4-methoxy-β-oxo-, ethyl ester
  • 2-[(4-methoxyphenyl)-oxomethyl]butanoate
  • Benzenepropanoicacid,4-methoxy-.beta.-oxo-,ethylester
  • AKOS 228-23
  • 4-METHOXYBENZOYLACETIC ACID ETHYL ESTER
  • ETHYL P-ANISOYLACETATE
  • ETHYL 4-METHOXYBENZOYLACETATE
  • ETHYL 3-(4-METHOXY-PHENYL)-3-OXOPROPANOATE
  • ETHYL 3(-4METHOXYPHENYL)-3-OXOPROPIONATE
  • BUTTPARK 18\10-44
  • Ethyl p-methoxybenzoyl acetate
  • p-Methoxybenzoyl acetic acid, ethyl ester
  • Ethyl4-Methoxybenzoylacetate&gt
  • Benzenepropanoic acid, 4-methoxy-beta-oxo-, ethyL
  • Ethyl 3-(4-methoxyphenyl)-3-oxopropanoate (or) ethyl (4-methoxybenzoyl)acetate
  • 2881-83-6
  • Organic Building Blocks
  • Esters
  • Building Blocks
  • C12 to C63
  • Carbonyl Compounds
  • Pharmaceutical Intermediates
  • Benzoic acid