ETHYL 4-METHOXYBENZOYLACETATE
- Product Name
- ETHYL 4-METHOXYBENZOYLACETATE
- CAS No.
- 2881-83-6
- Chemical Name
- ETHYL 4-METHOXYBENZOYLACETATE
- Synonyms
- MOBEE;AKOS 228-23;BUTTPARK 18\10-44;ETHYL P-ANISOYLACETATE;ETHYL 4-METHOXYBENZOYLACETATE;Ethyl p-methoxybenzoyl acetate;Ethyl4-Methoxybenzoylacetate>P-ANISOYLACETIC ACID ETHYL ESTER;Acetic acid, p-anisoyl-, ethyl ester;4-METHOXYBENZOYLACETIC ACID ETHYL ESTER
- CBNumber
- CB0240202
- Molecular Formula
- C12H14O4
- Formula Weight
- 222.24
- MOL File
- 2881-83-6.mol
ETHYL 4-METHOXYBENZOYLACETATE Property
- Boiling point:
- 154 °C1 hPa(lit.)
- Density
- 1.160 g/mL at 20 °C(lit.)
- refractive index
- 1.5410 to 1.5460
- Flash point:
- 115°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- H2O: soluble
- form
- clear liquid
- pka
- 10.34±0.25(Predicted)
- color
- Light yellow to Yellow to Orange
- InChI
- InChI=1S/C12H14O4/c1-3-16-12(14)8-11(13)9-4-6-10(15-2)7-5-9/h4-7H,3,8H2,1-2H3
- InChIKey
- KRAHENMBSVAAHD-UHFFFAOYSA-N
- SMILES
- C1(=CC=C(OC)C=C1)C(=O)CC(=O)OCC
- CAS DataBase Reference
- 2881-83-6(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenepropanoic acid, 4-methoxy-.beta.-oxo-, ethyl ester (2881-83-6)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 2918.99.4700
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M1380
- Product name
- Ethyl (4-Methoxybenzoyl)acetate
- Packaging
- 5G
- Price
- $30
- Updated
- 2025/07/31
- Product number
- M1380
- Product name
- Ethyl (4-Methoxybenzoyl)acetate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $137
- Updated
- 2025/07/31
- Product number
- J55409
- Product name
- Ethyl (4-Methoxybenzoyl)acetate
- Packaging
- 500g
- Price
- $1280
- Updated
- 2021/12/16
- Product number
- CHM0014345
- Product name
- ETHYL 4-METHOXYBENZOYLACETATE
- Purity
- 95.00%
- Packaging
- 250G
- Price
- $4361.9
- Updated
- 2021/12/16
- Product number
- CHM0014345
- Product name
- ETHYL 4-METHOXYBENZOYLACETATE
- Purity
- 95.00%
- Packaging
- 25KG
- Price
- $9141.83
- Updated
- 2021/12/16
ETHYL 4-METHOXYBENZOYLACETATE Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron Letters, 14, p. 4207, 1973 DOI: 10.1016/S0040-4039(01)87150-1
Synthesis, p. 290, 1993 DOI: 10.1055/s-1993-25849
Synthesis
100-06-1
105-58-8
2881-83-6
To a stirred mixture of sodium hydride (3 mol eq.) and diethyl carbonate (4 mol eq.) in 50 mL of tetrahydrofuran (THF) washed with hexane (3 x 15 mL), p-methoxyacetophenone (1 mol eq.) was slowly added dropwise for a controlled period of 30 min or more. The reaction mixture was heated and refluxed for 3-4 h until the color of the reaction solution changed to dark brown and the reaction progress was monitored by thin layer chromatography (TLC, unfolding agent 10% ethyl acetate/hexane). Upon completion of the reaction, the mixture was cooled to room temperature and acidified with 5 mL of glacial acetic acid, followed by the addition of 100 mL of ice-cold dilute hydrochloric acid solution. The aqueous phase was extracted with ethyl acetate (3 x 75 mL) and the organic phases were combined and washed sequentially with saturated sodium bicarbonate solution, saturated saline and deionized water. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 3-(4-methoxyphenyl)-3-oxopropanoate as a viscous substance in good yield. The structure of the product was confirmed by 1H NMR and 13C NMR spectroscopy and the data were in agreement with literature reports.
References
[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 31, p. 4543 - 4547
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 14, p. 4237 - 4244
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 34, p. 8661 - 8664
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[5] European Journal of Organic Chemistry, 2012, # 35, p. 6976 - 6985
ETHYL 4-METHOXYBENZOYLACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 4-METHOXYBENZOYLACETATE Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
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View Lastest Price from ETHYL 4-METHOXYBENZOYLACETATE manufacturers
- Product
- ETHYL 4-METHOXYBENZOYLACETATE 2881-83-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Ethyl (4-Methoxybenzoyl)acetate 2881-83-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- ETHYL 4-METHOXYBENZOYLACETATE 2881-83-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09