4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
- Product Name
- 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
- CAS No.
- 101574-65-6
- Chemical Name
- 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
- Synonyms
- CS-1084;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide;4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE;2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid;4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide;Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
- CBNumber
- CB02446303
- Molecular Formula
- C17H18N2O2
- Formula Weight
- 282.34
- MOL File
- 101574-65-6.mol
4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Property
- Density
- 1.12
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 8.48±0.15(Predicted)
- color
- white to off-white
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 43-50/53
- Safety Statements
- 36/37-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HazardClass
- 9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- G6173
- Product name
- GSK 4716
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- G6173
- Product name
- GSK 4716
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- J65166
- Product name
- GSK 4716
- Packaging
- 50mg
- Price
- $248
- Updated
- 2021/12/16
- Product number
- J65166
- Product name
- GSK 4716
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 17233
- Product name
- GSK 4716
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Chemical Properties,Usage,Production
Description
The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.
Uses
The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]
Uses
Selective agonist at estrogen-related receptors ERR and ERR
Definition
ChEBI: GSK 4716 is a monoterpenoid.
Biological Activity
Selective agonist at estrogen-related receptors ERR β and ERR γ . Displays selectivity over ERR α and the classical estrogen receptors.
storage
Store at +4°C
4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE manufacturers
- Product
- 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE 101574-65-6
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31