Presatovir

Product Name: Presatovir
CAS No.: 1353625-73-6
Chemical Name: Presatovir
Synonyms: CS-2075;GS-5806;Presatovir;GS-5806 Presatovir;Presatovir (GS-5806);Presatovir,inhibit,Inhibitor,Respiratory syncytial virus,GS5806,GS 5806,RSV;N-(2-((S)-2-(5-((S)-3-aminopyrrolidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide;N-{2-[(2S)-2-{5-[(3S)-3-aminopyrrolidin-1-yl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl}piperidine-1-carbonyl]-4-chlorophenyl}methanesulfonamide;N-(2-{[(2S)-2-{5-[(3S)-3-Amino-1-pyrrolidinyl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl}-1-piperidinyl]carbonyl}-4-chlorophenyl)methanesulfonamide;Methanesulfonamide, N-[2-[[(2S)-2-[5-[(3S)-3-amino-1-pyrrolidinyl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl]-1-piperidinyl]carbonyl]-4-chlorophenyl]-
CBNumber: CB03041448
Molecular Formula: C24H30ClN7O3S
Formula Weight: 532.06
MOL File: 1353625-73-6.mol

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Presatovir Property

Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6 mg/mL (11.28 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 7.12±0.10(Predicted)
color: Off-white to light yellow
InChIKey: GOFXWTVKPWJNGD-UWJYYQICSA-N
SMILES: CS(NC1=CC=C(Cl)C=C1C(N1CCCC[C@H]1C1C=C2N(N=1)C=C(C)C(N1CC[C@H](N)C1)=N2)=O)(=O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4596
Product name: Presatovir
Purity: 99.95%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-4596
Product name: Presatovir
Purity: 99.95%
Packaging: 10mg
Price: $720
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611815
Product name: Presatovir
Packaging: 10mg
Price: $734.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611815
Product name: Presatovir
Packaging: 50mg
Price: $2157.3
Updated: 2021/12/16

ChemScene

Product number: CS-4596
Product name: Presatovir
Purity: 99.95%
Packaging: 50mg
Price: $2160
Updated: 2021/12/16

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Presatovir Chemical Properties,Usage,Production

Uses

Presatovir (GS-5806) is an orally bioavailable RSV fusion inhibitor with a mean EC50 value of 0.43 nM[1].

in vivo

Presatovir demonstrates dose-dependent (0-30 mg/kg) antiviral efficacy in a cotton rat model of RSV infection. Oral bioavailability in preclinical species ranges from 46 to 100%, with penetration of the compound into the lung tissue demonstrated in Sprague-Dawley rats. Multidose oral treatment of Presatovir appears safe in adults, and in healthy human volunteers experimentally infected with RSV, a potent antiviral effect and reduction in disease severity is observed in the high dose group. A group treated with a lower dose of Presatovir allows for a PK-PD relationship to be established to help guide future dose selections^[1].

References

[1] Mackman RL, et al. Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-1643. DOI:10.1021/jm5017768
[2] Samuel D, et al. GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein. Antimicrob Agents Chemother. 2015 Nov;59(11):7109-12. DOI:10.1128/AAC.00761-15

Presatovir Preparation Products And Raw materials

Raw materials

Preparation Products

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Presatovir Suppliers

China 60 India 1 United States 6 Global 67

DKMbiochem.Co. Ltd

Tel: 15901859516
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Shanghai Jian Chao Chemical Technology Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Country: China
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MedChemexpress LLC

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Country: United States
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Bide Pharmatech Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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Guangzhou QiYun Biotechnology Co., Ltd.

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1353625-73-6, PresatovirRelated Search:

Entospletinib (GS-9973) GS9620 GSK2643943A GS967 GSK J1 GSK-114 GSK-626616 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Selonsertib 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

CS-2075

Presatovir

GS-5806

N-(2-((S)-2-(5-((S)-3-aminopyrrolidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide

Presatovir (GS-5806)

N-(2-{[(2S)-2-{5-[(3S)-3-Amino-1-pyrrolidinyl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl}-1-piperidinyl]carbonyl}-4-chlorophenyl)methanesulfonamide

Methanesulfonamide, N-[2-[[(2S)-2-[5-[(3S)-3-amino-1-pyrrolidinyl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl]-1-piperidinyl]carbonyl]-4-chlorophenyl]-

Presatovir,inhibit,Inhibitor,Respiratory syncytial virus,GS5806,GS 5806,RSV

N-{2-[(2S)-2-{5-[(3S)-3-aminopyrrolidin-1-yl]-6-methylpyrazolo[1,5-a]pyrimidin-2-yl}piperidine-1-carbonyl]-4-chlorophenyl}methanesulfonamide

GS-5806 Presatovir

1353625-73-6

C24H30ClN7O3S