1-TRITYL-1H-1,2,4-TRIAZOLE
- Product Name
- 1-TRITYL-1H-1,2,4-TRIAZOLE
- CAS No.
- 31250-99-4
- Chemical Name
- 1-TRITYL-1H-1,2,4-TRIAZOLE
- Synonyms
- 1-trityl-1,2,4-triazole;1-TRITYL-1H-1,2,4-TRIAZOLE;1-triphenylmethyl-1,2,4-triazole;1-(triphenylMethyl)-1H-1,2,4-Triazole;1H-1,2,4-Triazole, 1-(triphenylmethyl)-
- CBNumber
- CB02446550
- Molecular Formula
- C21H17N3
- Formula Weight
- 311.38
- MOL File
- 31250-99-4.mol
1-TRITYL-1H-1,2,4-TRIAZOLE Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM1041755
- Product name
- 1-TRITYL-1H-1,2,4-TRIAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.72
- Updated
- 2021/12/16
- Product number
- CM124885
- Product name
- 1-trityl-1H-1,2,4-triazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $206
- Updated
- 2021/12/16
- Product number
- 31250994
- Product name
- 1-Trityl-1H-1,2,4-triazole
- Packaging
- 1g
- Price
- $215.6
- Updated
- 2021/12/16
- Product number
- CM124885
- Product name
- 1-trityl-1H-1,2,4-triazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $617
- Updated
- 2021/12/16
- Product number
- CD11147626
- Product name
- 1-Trityl-1H-1,2,4-triazole
- Purity
- 95+%
- Packaging
- 5g
- Price
- $621
- Updated
- 2021/12/16
1-TRITYL-1H-1,2,4-TRIAZOLE Chemical Properties,Usage,Production
Synthesis
288-88-0
76-83-5
31250-99-4
Triethylamine (5.49 g, 54.30 mmol) was added to a solution of 1,2,4-triazole (3.0 g, 43.44 mmol) in N,N-dimethylformamide (DMF, 50 mL) at room temperature. After stirring for 5 min, triphenylchloromethane (12.11 g, 43.44 mmol) was added and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was partitioned between dichloromethane (50 mL) and water (50 mL) to separate the organic layer. The aqueous layer was extracted with dichloromethane (3 x 50 mL) and the organic layers were combined. The organic layer was washed with water (3 x 40 mL) and then dried over anhydrous sodium sulfate (Na2SO4). The organic layer was concentrated under reduced pressure to afford 1-trityl-1H-1,2,4-triazole (12.6 g, 93% yield). N-butyllithium (n-BuLi, 4.5 mL, 11.24 mmol; 2.5 M hexane solution) was added to a solution of tetrahydrofuran (THF, 120 mL) of 1-trityl-1H-1,2,4-triazole (3.5 g, 11.24 mmol) and stirred for 45 min at -78 °C. Bromine (1.76 g, 11.02 mmol) was added dropwise over 5 min and stirring was continued for 2 h at -78 °C. The reaction mixture was then allowed to slowly warm to -20°C and the reaction was quenched by addition of saturated ammonium chloride (NH4Cl) solution (30 mL). The reaction mixture was diluted with water (60 mL) and dichloromethane (40 mL) and the organic layer was separated. The aqueous layer was extracted with dichloromethane (4 x 50 mL) and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and the solvent was evaporated under reduced pressure to give the crude product (4.2 g, 95% yield), which was used directly in the next step. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR) data: δ 7.09-7.16 (m, 6H), 7.27-7.40 (m, 9H), 7.86 (s, 1H).
References
[1] Patent: WO2014/159248, 2014, A1. Location in patent: Paragraph 0185
[2] European Journal of Medicinal Chemistry, 2009, vol. 44, # 7, p. 3064 - 3067
[3] Tetrahedron, 1997, vol. 53, # 30, p. 10289 - 10312
[4] MedChemComm, 2014, vol. 5, # 1, p. 72 - 81
[5] Patent: US6620841, 2003, B1
1-TRITYL-1H-1,2,4-TRIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-TRITYL-1H-1,2,4-TRIAZOLE manufacturers
- Product
- 1-TRITYL-1H-1,2,4-TRIAZOLE 31250-99-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19