5-BROMO-2(3H)-BENZOTHIAZOLONE
- Product Name
- 5-BROMO-2(3H)-BENZOTHIAZOLONE
- CAS No.
- 199475-45-1
- Chemical Name
- 5-BROMO-2(3H)-BENZOTHIAZOLONE
- Synonyms
- 5-Bromobenzothiazolone;5-bromobenzo[d]thiazol-2-ol;5-Bromobenzo[d]thiazol-2-one;5-Bromobenzo[d]thiazol-2(3H);5-BROMO-2(3H)-BENZOTHIAZOLONE;2(3H)-Benzothiazolone, 5-bromo-;5-BroMobenzo[d]thiazol-2(3H)-one;5-bromo-3H-1,3-benzothiazol-2-one;5-BroMobenzo[d]thiazol-2(3H)-one 2(3H)
- CBNumber
- CB02446626
- Molecular Formula
- C7H4BrNOS
- Formula Weight
- 230.08
- MOL File
- 199475-45-1.mol
5-BROMO-2(3H)-BENZOTHIAZOLONE Property
- Melting point:
- 242-243 °C(Solv: ethanol (64-17-5))
- Density
- 1.815±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.57±0.20(Predicted)
- Appearance
- Off-white to pink Solid
Safety
- HS Code
- 29342000
N-Bromosuccinimide Price
- Product number
- HCH0367078
- Product name
- 5-BROMOBENZO[D]THIAZOL-2(3H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.95
- Updated
- 2021/12/16
- Product number
- Z4373
- Product name
- 5-Bromobenzo[d]thiazol-2(3H)-one
- Packaging
- 1g
- Price
- $590
- Updated
- 2021/12/16
- Product number
- A136145
- Product name
- 5-Bromobenzo[d]thiazol-2(3H)-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- A136145
- Product name
- 5-Bromobenzo[d]thiazol-2(3H)-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- A136145
- Product name
- 5-Bromobenzo[d]thiazol-2(3H)-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
5-BROMO-2(3H)-BENZOTHIAZOLONE Chemical Properties,Usage,Production
Chemical Properties
White crystalline
Synthesis
32315-10-9
93933-49-4
199475-45-1
The general procedure for the synthesis of 2(3H)-5-bromobenzothiazolone from tritiated gas and 2-amino-4-bromobenzenethiol was as follows: 2-amino-4-bromobenzenethiol (544 mg, 2.67 mmol) was dissolved in acetic acid (26.7 mL), followed by the addition of tritiated gas (530 mg, 1.79 mmol). The reaction mixture was heated to reflux for 18 hours. Upon completion of the reaction, it was cooled to room temperature, some of the solvent was concentrated under reduced pressure, water was added, and the precipitate was collected by filtration and washed with 1.0 M NaOH aqueous solution. The filtrate was acidified to pH 2 with 2 N HCl and then placed in a refrigerator for 12 hours. The precipitate was precipitated by filtration, washed with water and dried under reduced pressure to give 2(3H)-5-bromobenzothiazolone (94 mg, 15% yield) as a powder to be further purified. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 12.07 (s, 1H), 7.55 (d, J = 8.4 Hz, 1H), 7.30 (d, J = 8.0 Hz, 1H), 7.24 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 24, p. 10151 - 10171
[2] Patent: WO2017/205536, 2017, A2. Location in patent: Page/Page column 83; 84
[3] Patent: WO2014/190199, 2014, A1. Location in patent: Paragraph 00285
5-BROMO-2(3H)-BENZOTHIAZOLONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2(3H)-BENZOTHIAZOLONE manufacturers
- Product
- 5-bromo-3H-1,3-benzothiazol-2-one 199475-45-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.8%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14