2-CHLORO-5-FLUOROBENZOTHIAZOLE
- Product Name
- 2-CHLORO-5-FLUOROBENZOTHIAZOLE
- CAS No.
- 154327-27-2
- Chemical Name
- 2-CHLORO-5-FLUOROBENZOTHIAZOLE
- Synonyms
- 2-CHLORO-5-FLUOROBENZOTHIAZOLE;Benzothiazole, 2-chloro-5-fluoro-;2-Chloro-5-fluorobenzo[d]thiazole
- CBNumber
- CB32450103
- Molecular Formula
- C7H3ClFNS
- Formula Weight
- 187.62
- MOL File
- 154327-27-2.mol
2-CHLORO-5-FLUOROBENZOTHIAZOLE Property
- Boiling point:
- 253.0±13.0 °C(Predicted)
- Density
- 1.532±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.36±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 29342000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C367528
- Product name
- 2-chloro-5-fluoro-1,3-benzothiazole
- Packaging
- 50mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- C367528
- Product name
- 2-chloro-5-fluoro-1,3-benzothiazole
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- Z4207
- Product name
- 2-Chloro-5-fluorobenzothiazole
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- HCH0357779
- Product name
- 2-CHLORO-5-FLUOROBENZOTHIAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.29
- Updated
- 2021/12/16
- Product number
- Z4207
- Product name
- 2-Chloro-5-fluorobenzothiazole
- Packaging
- 5g
- Price
- $606
- Updated
- 2021/12/16
2-CHLORO-5-FLUOROBENZOTHIAZOLE Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Synthesis
155559-81-2
154327-27-2
General procedure for the synthesis of 2-chloro-5-fluorobenzothiazole from 5-fluoro-2-mercaptobenzothiazole: Thionyl chloride (0.3 mL, 4.41 mmol) was slowly added dropwise to 5-fluoro-2-mercaptobenzothiazole (680 mg, 3.67 mmol). The reaction mixture was stirred at room temperature for 1 h. The reaction was then warmed up to 60 °C and continued for 40 min. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The dried organic phases were concentrated under reduced pressure to afford the target product 2-chloro-5-fluorobenzothiazole (520 mg, 2.75 mmol, 75% yield).ESI-MS (M + 1): 187 (calculated value: C7H3ClFNS, 186).
References
[1] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 57
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670
[3] Patent: US2004/224997, 2004, A1. Location in patent: Page 32; 33
[4] Patent: WO2017/88759, 2017, A1. Location in patent: Paragraph 00233
2-CHLORO-5-FLUOROBENZOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-5-FLUOROBENZOTHIAZOLE manufacturers
- Product
- 2-Chloro-5-fluorobenzothiazole 154327-27-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 2-CHLORO-5-FLUOROBENZOTHIAZOLE 154327-27-2
- Price
- US $1.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-28