ChemicalBook > CAS DataBase List > 2-CHLORO-5-FLUOROBENZOTHIAZOLE

2-CHLORO-5-FLUOROBENZOTHIAZOLE

Product Name: 2-CHLORO-5-FLUOROBENZOTHIAZOLE
CAS No.: 154327-27-2
Chemical Name: 2-CHLORO-5-FLUOROBENZOTHIAZOLE
Synonyms: 2-CHLORO-5-FLUOROBENZOTHIAZOLE;Benzothiazole, 2-chloro-5-fluoro-;2-Chloro-5-fluorobenzo[d]thiazole
CBNumber: CB32450103
Molecular Formula: C7H3ClFNS
Formula Weight: 187.62
MOL File: 154327-27-2.mol

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2-CHLORO-5-FLUOROBENZOTHIAZOLE Property

Boiling point:: 253.0±13.0 °C(Predicted)
Density: 1.532±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.36±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 29342000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C367528
Product name: 2-chloro-5-fluoro-1,3-benzothiazole
Packaging: 50mg
Price: $205
Updated: 2021/12/16

TRC

Product number: C367528
Product name: 2-chloro-5-fluoro-1,3-benzothiazole
Packaging: 100mg
Price: $285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0357779
Product name: 2-CHLORO-5-FLUOROBENZOTHIAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $505.29
Updated: 2021/12/16

AK Scientific

Product number: Z4207
Product name: 2-Chloro-5-fluorobenzothiazole
Packaging: 5g
Price: $606
Updated: 2021/12/16

AK Scientific

Product number: Z4207
Product name: 2-Chloro-5-fluorobenzothiazole
Packaging: 250mg
Price: $134
Updated: 2021/12/16

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2-CHLORO-5-FLUOROBENZOTHIAZOLE Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Synthesis

155559-81-2

154327-27-2

General procedure for the synthesis of 2-chloro-5-fluorobenzothiazole from 5-fluoro-2-mercaptobenzothiazole: Thionyl chloride (0.3 mL, 4.41 mmol) was slowly added dropwise to 5-fluoro-2-mercaptobenzothiazole (680 mg, 3.67 mmol). The reaction mixture was stirred at room temperature for 1 h. The reaction was then warmed up to 60 °C and continued for 40 min. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The dried organic phases were concentrated under reduced pressure to afford the target product 2-chloro-5-fluorobenzothiazole (520 mg, 2.75 mmol, 75% yield).ESI-MS (M + 1): 187 (calculated value: C7H3ClFNS, 186).

References

[1] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 57
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670
[3] Patent: US2004/224997, 2004, A1. Location in patent: Page 32; 33
[4] Patent: WO2017/88759, 2017, A1. Location in patent: Paragraph 00233

2-CHLORO-5-FLUOROBENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUOROBENZOTHIAZOLE Suppliers

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View Lastest Price from 2-CHLORO-5-FLUOROBENZOTHIAZOLE manufacturers

Honest Joy Holdings Limited

Product: 2-Chloro-5-fluorobenzothiazole 154327-27-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 2-CHLORO-5-FLUOROBENZOTHIAZOLE 154327-27-2
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2019-08-28

154327-27-2, 2-CHLORO-5-FLUOROBENZOTHIAZOLERelated Search:

6-CHLORO-3H-BENZOTHIAZOL-2-ONE 5-Bromo-2-mercaptobenzothiazole 5--fluoro-2(3H)-benzothiazolone 2-HYDROXY-4-METHYL-BENZOTHIOZOLE 5-BROMO-2(3H)-BENZOTHIAZOLONE 6-METHOXY-2(3H)-BENZOTHIAZOLONE 2-Chloro-6-fluorobenzothiazole Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI) 2,4-Dichlorobenzothiazole 2-Chloro-4-fluorobenzothiazole 2,6-Dichlorobenzothiazole 6-Bromo-2-chlorobenzothiazole 2,7-Dichlorobenzothiazole 5-BROMO-2-CHLOROBENZOTHIAZOLE 2-CHLORO-5,6-DIFLUOROBENZOTHIAZOLE 2-Chloro-4,5-difluorobenzothiazole 2-CHLORO-5,7-DIFLUOROBENZOTHIAZOLE 2-CHLORO-5-FLUOROBENZOTHIAZOLE

2-CHLORO-5-FLUOROBENZOTHIAZOLE

2-Chloro-5-fluorobenzo[d]thiazole

Benzothiazole, 2-chloro-5-fluoro-

154327-27-2