2-Chloro-6-fluorobenzothiazole

Product Name: 2-Chloro-6-fluorobenzothiazole
CAS No.: 399-74-6
Chemical Name: 2-Chloro-6-fluorobenzothiazole
Synonyms: IFLAB-BB F1910-0016;2-CHLORO-6-FLUOROBENZOTHIAZOLE;2-CHLORO-6-FLUOROBENZO[D]THIAZOLE;Benzothiazole, 2-chloro-6-fluoro-;2-CHLORO-6-FLUORO-1,3-BENZOTHIAZOLE;Benzothiazole, 2-chloro-6-fluoro- (8CI,9CI);JR-8570, 2-Chloro-6-fluorobenzo[d]thiazole, 97%
CBNumber: CB8380946
Molecular Formula: C7H3ClFNS
Formula Weight: 187.62
MOL File: 399-74-6.mol

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2-Chloro-6-fluorobenzothiazole Property

Melting point:: 91-95 °C
Boiling point:: 253.0±13.0 °C(Predicted)
Density: 1.532±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -0.39±0.10(Predicted)
color: White to Light yellow
CAS DataBase Reference: 399-74-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29342000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 667358
Product name: 2-Chloro-6-fluorobenzothiazole
Purity: 97%
Packaging: 1g
Price: $57.4
Updated: 2023/06/20

Sigma-Aldrich

Product number: 667358
Product name: 2-Chloro-6-fluorobenzothiazole
Purity: 97%
Packaging: 5g
Price: $245
Updated: 2023/06/20

TCI Chemical

Product number: C2607
Product name: 2-Chloro-6-fluorobenzothiazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $100
Updated: 2025/07/31

TCI Chemical

Product number: C2607
Product name: 2-Chloro-6-fluorobenzothiazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $396
Updated: 2025/07/31

TRC

Product number: C584905
Product name: 2-Chloro-6-fluorobenzo[d]thiazole
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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2-Chloro-6-fluorobenzothiazole Chemical Properties,Usage,Production

Chemical Properties

White solid

Biological Activity

2-Chloro-6-fluorobenzothiazole is a potent inhibitor of diacylglycerol acyltransferase, an enzyme involved in the biosynthesis of triglycerides. It has been shown to inhibit the enzymatic activity of this enzyme and decrease triglyceride levels by inhibiting the production of fatty acids.

Synthesis

348-40-3

399-74-6

General procedure for the synthesis of 2-chloro-6-fluorobenzothiazole from 2-amino-6-fluorobenzothiazole: In a round-bottomed flask, 2-amino-6-fluorobenzothiazole (1.0017 g, 5.96 mmol, Sigma-Aldrich Chemical Company, Inc.), copper(II) chloride (1.201 g, 8.93 mmol, Sigma-Aldrich Chemical Company, Inc.) and tert-butyl nitrite (1.063 mL, 8.93 mmol, Acros Organics) in acetonitrile (ACN). The reaction mixture was heated to 65 °C and kept at this temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 2-chloro-6-fluorobenzothiazole (0.9249 g, 4.93 mmol, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.45 (td, J = 9.10, 2.74 Hz, 1H), 7.97-8.07 (m, 2H).

References

[1] Patent: US2013/225552, 2013, A1. Location in patent: Paragraph 0976
[2] Patent: WO2012/69503, 2012, A1. Location in patent: Page/Page column 18-19
[3] Patent: US2013/172326, 2013, A1. Location in patent: Paragraph 0081; 0082
[4] Journal of the Indian Chemical Society, 1933, vol. 10, p. 465,469
[5] Farmaco, Edizione Scientifica, 1977, vol. 32, p. 348 - 354

2-Chloro-6-fluorobenzothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-fluorobenzothiazole Suppliers

Americas 1 Canada 1 China 138 Europe 2 India 5 Japan 1 Switzerland 1 United Kingdom 6 United States 24 Global 179

J & K SCIENTIFIC LTD.

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Pure Chemistry Scientific Inc.

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Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from 2-Chloro-6-fluorobenzothiazole manufacturers

Honest Joy Holdings Limited

Product: 2-Chloro-6-fluorobenzo[d]thiazole 399-74-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.4%
Supply Ability: 100 tons
Release date: 2022-01-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-6-fluorobenzothiazole 399-74-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 2-Chloro-6-fluorobenzothiazole 399-74-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

399-74-6, 2-Chloro-6-fluorobenzothiazoleRelated Search:

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IFLAB-BB F1910-0016

2-CHLORO-6-FLUOROBENZO[D]THIAZOLE

JR-8570, 2-Chloro-6-fluorobenzo[d]thiazole, 97%

2-CHLORO-6-FLUOROBENZOTHIAZOLE

2-CHLORO-6-FLUORO-1,3-BENZOTHIAZOLE

Benzothiazole, 2-chloro-6-fluoro- (8CI,9CI)

Benzothiazole, 2-chloro-6-fluoro-

399-74-6

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Thiazoles

BENZOTHIAZOLE

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiazoles

ThiazolesHeterocyclic Building Blocks