Flucloxacillin sodium

Product Name: Flucloxacillin sodium
CAS No.: 1847-24-1
Chemical Name: Flucloxacillin sodium
Synonyms: ucL;mfi-pc;Gulpen;oxaciL;in sodium;NSC 277175;FK 900 sodium;Flucloxacilli;floxapensodium;Staphylex Sodiu
CBNumber: CB0670388
Molecular Formula: C19H18ClFN3NaO5S
Formula Weight: 477.87
MOL File: 1847-24-1.mol

More

Less

Flucloxacillin sodium Property

Melting point:: 176-178°C
Boiling point:: 677℃
RTECS: XH8680000
Flash point:: >110°(230°F)
storage temp.: 2-8°C
solubility: H2O: soluble20mg/mL, clear
form: powder
color: white to beige
Water Solubility: Soluble in water
Sensitive: Light Sensitive
InChIKey: OTEANHMVDHZOPB-SLINCCQESA-M
SMILES: C([C@H]1C(S[C@]2([H])[C@H](NC(C3=C(ON=C3C3C(=CC=CC=3Cl)F)C)=O)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,r|
CAS DataBase Reference: 1847-24-1(CAS DataBase Reference)

More

Less

Safety

WGK Germany: 3
Toxicity: LD50 oral in rabbit: > 8gm/kg

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1023
Product name: Flucloxacillin sodium
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $114.95
Updated: 2025/07/31

Sigma-Aldrich

Product number: F0150000
Product name: Flucloxacillin sodium
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 250 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP158
Product name: Flucloxacillin sodium
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 250MG
Price: $274
Updated: 2025/07/31

Sigma-Aldrich

Product number: 32353
Product name: Flucloxacillin sodium
Purity: VETRANAL
Packaging: 100mg
Price: $95.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: F0150000
Product name: Flucloxacillin sodium
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: F0150000
Price: $151
Updated: 2023/06/20

More

Less

Flucloxacillin sodium Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Antibacterial;Peptidoglycan synthesis inhibitor

Uses

Flucloxacillin sodium has been used as a β-lactam antibiotic to study its effects on methicillin-resistant?Staphylococcus aureus?(MRSA) ΔfloA?mutant.

Uses

Flucloxacillin, a new semisynthetic penicillin

Definition

ChEBI: Flucloxacillin sodium is an organic sodium salt. It contains a flucloxacillin(1-).

General Description

Flucloxacillin sodium, a sodium salt of flucloxacillin, is a member of the penicillin class.

Biochem/physiol Actions

Flucloxacillin exhibits antimicrobial property.

Synthesis

5250-39-5

1847-24-1

To the reaction flask was added 100 g of deionized water and 20.0 g of 6-aminopenicillanic acid (6-APA) was slowly added under stirring conditions, after which the reaction system was cooled to 0-5 °C. Accurately weighed 10.6 g of sodium carbonate and dissolved in 100 mL of deionized water to prepare a 1 mol/L solution of sodium carbonate. Keeping the reaction temperature below 10 °C, the sodium carbonate solution was slowly added dropwise to the reaction flask to obtain an aqueous sodium salt solution of 6-APA. Next, 28.0 g of 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid chloride was added to the reaction system and the addition time was controlled to be within 1 hour. The reaction system was stirred at 20~25°C for 4 hours. After completion of the reaction, the pH of the reaction solution was slowly adjusted to 2.5 with 1 mol/L dilute hydrochloric acid. 400 g of ethyl acetate was added to the reaction flask, and liquid-liquid partitioning was carried out after thorough stirring to separate the ethyl acetate phase. The ethyl acetate phase was washed sequentially with 200 g of saturated sodium chloride solution and then dried with 20 g of anhydrous sodium sulfate for 30 min to obtain an ethyl acetate solution of flucloxacillinic acid. A 1 mol/L solution of sodium isooctanoate was prepared by accurately weighing 18.0 g of sodium isooctanoate and dissolving it in 108 mL of ethyl acetate. This sodium isooctanoate solution was slowly added dropwise to the ethyl acetate solution of flucloxacillinic acid, and after the dropwise addition was completed, a white solid was gradually precipitated in the system. The reaction system was cooled to 5-10°C and crystallization was continued for 3 hours. The solid was collected by filtration, washed twice with ethyl acetate and subsequently dried under vacuum at 50 °C to obtain 41.3 g of flucloxacillin sodium monohydrate, the purity of the product was 99.8% as determined by HPLC and the yield was 90.6%.

References

[1] Patent: CN104910183, 2017, B. Location in patent: Paragraph 0032-0036; 0038-0042; 0043-0047; 0048-0051

Flucloxacillin sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Flucloxacillin sodium Suppliers

Canada 2 China 207 Europe 2 France 1 Germany 4 India 19 South Korea 1 United Kingdom 4 United States 23 Global 263

GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD

Tel: 020-37651955 13682223272
Fax: 020-87659730
Email: 173901442@qq.com
Country: China
ProdList: 694
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2766
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

More

Less

View Lastest Price from Flucloxacillin sodium manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Flucloxacillin sodium 1847-24-1
Price: US $45.00-39.00/kg
Min. Order: 1kg
Purity: 99.96%
Supply Ability: 1kg
Release date: 2023-03-13

Hangzhou ICH Biofarm Co., Ltd

Product: Flucloxacillin sodium 1847-24-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 20 tons
Release date: 2023-07-13

Hebei Fengqiang Trading Co., LTD

Product: Flucloxacillin sodium 1847-24-1
Price: US $100.00/bag
Min. Order: 1bag
Purity: 99
Supply Ability: 5000
Release date: 2023-09-05

1847-24-1, Flucloxacillin sodiumRelated Search:

Kresoxim-methyl Bensulfuron methyl METSULFURON METHYL Flucloxacillin Benzoxazole Methylparaben Sodium chloride Sodium bicarbonate Sodium benzoate Sodium acetate Dicloxacillin sodium Sodium chlorite Trisodium phosphate Famoxadone Methyl salicylate Sodium sulfate Sodium hydroxide Diclofenac sodium

(2s-(2-alpha,5-alpha,6-beta))-al

sodium [2S-(2alpha,5alpha,6beta)]-6-[[[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Flucloxacillin sodium BP98

3-dimethyl-7-oxo-henyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-monosodiums

4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((3-(2-chloro-6-fluorop

5-methyl-3-(2-chloro-6-fluorophenyl)-4-isoxazolylpenicillinsodium

floxacillinsodium

floxapensodium

flucloxacillinsodiumsalt

mfi-pc

monosodiumflucloxacillin

Sodium (2S,5R,6R)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

FLUCLOXACILLINACID

Staphylex Sodium

(2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium

Staphylex Sodiu

4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-, sodium salt (7CI)

NSC 277175

Sodium [3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin

Sodium flucloxacillin

6α-[[(5-Methyl-3-(2-chloro-6-fluorophenyl)isoxazol-4-yl)carbonyl]amino]penicillanic acid sodium salt

Gulpen

Flucloxacillin SodiuM oral

(2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt

Flucloxacillin SodiuM Sterile

FLUCLOXACILLIN SODIUM MONO

BRL 2039 sodium

FK 900 sodium

Flucloxacilli

FLUCLOXACILLIN SODIUM

Flucloxacillin Sodium Anhydrous

(2S,5R,6R)-6-(3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,sodium salt

Flucloxacillin sodium CRS

in sodium

oxaciL

ucL

Flucloxacillin sodium USP/EP/BP

sodium 6-(3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Flucloxacillin SodiumQ: What is Flucloxacillin Sodium Q: What is the CAS Number of Flucloxacillin Sodium Q: What is the storage condition of Flucloxacillin Sodium Q: What are the applications of Flucloxacillin Sodium

sodium (2S,5R,6R)-6-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

C13696000 Flucloxacillin sodium

Phenylbutazone Impurity 29

Flucloxacillin sodium RS

1847-24-1

C19H16ClFN3O5SNa

C19H17ClFN3O5S

C19H16ClFN3NaO5S

C19H16CIFN3O5SNaH2O

Isoquinolines ,Quinolines ,Quinaldines

Peptide Synthesis/Antibiotics

API

Intermediates & Fine Chemicals

Pharmaceuticals

APIs

1847-24-1