Dicloxacillin sodium
Brand Name(s) in US- Product Name
- Dicloxacillin sodium
- CAS No.
- 13412-64-1
- Chemical Name
- Dicloxacillin sodium
- Synonyms
- Dicloxacillin sodium;Dicloxacillin sodium CRS;Dicloxacillin Sodium (500 mg);Dicloxacillin Sodium (300 mg);icloxacillinsodiummonohydrate;Dicloxacillin sodium USP/EP/BP;Dicloxacillin Sodium (1189009);DICLOXACILLIN SODIUM WHO(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM EPD(CRM STANDARD)
- CBNumber
- CB4679268
- Molecular Formula
- C19H20Cl2N3NaO6S
- Formula Weight
- 512.33
- MOL File
- 13412-64-1.mol
Dicloxacillin sodium Property
- Melting point:
- 222-225°C
- alpha
- D20 +127.2° (water)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- Soluble in water
- BRN
- 4778711
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 13412-64-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 22-26-36/37-45
- WGK Germany
- 2
- RTECS
- XH8925000
- HS Code
- 29411099
- Toxicity
- LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; >5 orally (Gloxhuber)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 46182
- Product name
- Dicloxacillin sodium salt hydrate
- Purity
- VETRANAL
- Packaging
- 100mg
- Price
- $59.5
- Updated
- 2024/03/01
- Product number
- 1189009
- Product name
- Dicloxacillin sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 300mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- J61581
- Product name
- Dicloxacillin sodium salt monohydrate
- Packaging
- 1g
- Price
- $73.4
- Updated
- 2024/03/01
- Product number
- J61581
- Product name
- Dicloxacillin sodium salt monohydrate
- Packaging
- 5g
- Price
- $197.65
- Updated
- 2024/03/01
- Product number
- 23770
- Product name
- Dicloxacillin (sodium salt hydrate)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $57
- Updated
- 2024/03/01
Dicloxacillin sodium Chemical Properties,Usage,Production
Brand Name(s) in US
Dynapen
Chemical Properties
White to off-white crystalline powder
Originator
Dynapen,Bristol,US,1968
Uses
Dicloxacillin sodium salt is used in the treatment of staphylococci resistant to penicillin G. Dicloxacillin binds to specific penicillin-binding proteins in the bacterial cell wall and therefore inhibits the last stage of bacterial cell wall synthesis. Cell lysis, mediated by bacterial cell wall autolytic enzymes, is the result. Dicloxacillin may interfere with autolysin inhibitors.
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
A semi-synthetic antibiotic related to Penicillin. Antibacterial.
Definition
ChEBI: Dicloxacillin sodium monohydrate is a hydrate. It contains a dicloxacillin sodium.
Manufacturing Process
A suspension of 6-aminopenicillanic acid (216 grams) in water (2 liters) was
adjusted to pH 6.8 by the addition of N aqueous sodium hydroxide
(approximately 1 liter) and the resulting solution was stirred vigorously while
a solution of 3-(2',6'-dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride
(290 grams) in acetone (1.5 liters) was added in one portion.
The temperature rose to 26°C and as reaction proceeded the free acid form of
the penicillin separated as a white solid. After 30 minutes the suspension was
cooled to 10°C and stirring was continued at this temperature for 1 hour
more. The mixture was then cooled to 0°C, centrifuged, and the solid product
washed with aqueous acetone (250 ml) and finally dried in an air oven at
30°C. The product (440 grams, 94%) had [α]D20 +106.3° (c 1 in EtOH) and
was shown by alkalimetric assay to be 97.5% pure.
The salt was prepared by dissolving the free acid form of the penicillin in the
equivalent amount of aqueous sodium bicarbonate and freeze drying the
resulting solution. The hydrated salt so obtained was shown by alkalimetric
assay to be 94% pure and to contain 6% water.
brand name
Dynapen (Apothecon).
Therapeutic Function
Antibacterial
General Description
The substitution of chlorine atoms on both carbons orthoto the position of attachment of the phenyl ring to the isoxazolering is presumed to enhance further the stability ofthe oxacillin congener dicloxacillin sodium, [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodiummonohydrate (Dynapen, Pathocil, Veracillin) and toproduce high plasma concentrations of it. Its medicinalproperties and use are similar to those of cloxacillinsodium. Progressive halogen substitution, however, alsoincreases the fraction bound to protein in the plasma, potentiallyreducing the concentration of free antibiotic inplasma and tissues. Its medicinal properties and use are thesame as those of cloxacillin sodium.
Veterinary Drugs and Treatments
The veterinary use of dicloxacillin has been primarily in the PO treatment of bone, skin, and other soft tissue infections in small animals when penicillinase-producing Staphylococcus species have been isolated. Because of its low oral bioavailability and short halflife, other drugs with good staph coverage are usually employed.
Dicloxacillin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dicloxacillin sodium manufacturers
- Product
- Dicloxacillin sodium 13412-64-1
- Price
- US $56.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-04-07
- Product
- Dicloxacillin sodium 13412-64-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-01
- Product
- Dicloxacillin sodium 13412-64-1
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2021-07-08