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Salinomycin

Product Name
Salinomycin
CAS No.
53003-10-4
Chemical Name
Salinomycin
Synonyms
SALINOMYCIN SODIUM;SALINOMYCIN SODIUM SALT;coxistac;Procoxacin;Salinomycin;SALINOMYCIN 90%;Antibiotic-61477;Salinomycin, >98%;SALINOMYCIN GRANULE;SalinoMycin 12% 24%
CBNumber
CB9161784
Molecular Formula
C42H70O11
Formula Weight
751
MOL File
53003-10-4.mol
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Salinomycin Property

Melting point:
112.5-113.5 °C(lit.)
Boiling point:
839.2±65.0 °C(Predicted)
alpha 
D25 -63° (c = 1 in ethanol)
Density 
1.18±0.1 g/cm3(Predicted)
Flash point:
>110°(230°F)
storage temp. 
Sealed in dry,2-8°C
solubility 
insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO
form 
White solid
pka
6.4 (DMF)
Water Solubility 
Soluble in methanol. Insoluble in water
Merck 
13,8415
Stability:
Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.
LogP
5.596 (est)
CAS DataBase Reference
53003-10-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
45-36-26
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
VO8620000
10
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
53003-10-4(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4526
Product name
Salinomycin
Purity
from Streptomyces albus, ≥98% (HPLC)
Packaging
5mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
13579
Product name
Salinomycin
Purity
≥90%
Packaging
5mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
13579
Product name
Salinomycin
Purity
≥90%
Packaging
10mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
13579
Product name
Salinomycin
Purity
≥90%
Packaging
50mg
Price
$94
Updated
2024/03/01
Cayman Chemical
Product number
13579
Product name
Salinomycin
Purity
≥90%
Packaging
100mg
Price
$163
Updated
2024/03/01
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Salinomycin Chemical Properties,Usage,Production

Description

Salinomycin was found in the culture mycelium of Streptomyces albus by Otake et al. of the University of Tokyo in 1973. Like other polyether ionophore antibiotics, it shows activity against gram-positive bacteria, fungi, and Coccidium. Salinomycin has been used as a feed additive to protect poultry against coccidial infections.

Chemical Properties

solid

Uses

antibacterial

Uses

Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.

Uses

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.

Definition

ChEBI: Salinomycin is a polyketide and a spiroketal. It has a role as an animal growth promotant and a potassium ionophore.

General Description

Chemical structure: polyether

Biological Activity

salinomycin (sal), which is a polyether ionophore antibiotic from streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with abc drug transporters, the wnt/β-catenin signaling pathway, or other pathways.

Biochem/physiol Actions

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.

in vitro

several hepatocellular carcinoma (hcc) cell lines were treated with sal. results showed that sal inhibited proliferation and decreased pcna levels. cell cycle analysis showed that sal caused cell cycle arrest in different phases. sal induced apoptosis as characterized by an increase in the bax/bcl-2 ratio. compared to control, β-catenin expression was down-regulated by sal treatment significantly. the ca2+ concentration in hcc cells was examined by flow cytometry and it was found that higher ca2+ concentrations were observed in sal treatment groups [1].

in vivo

the in vivo anti-tumor effect of sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in sal-treated groups decreased. immunohistochemistry and tunel staining also demonstrated that sal could in vivo inhibit proliferation and induced apoptosis [1].

IC 50

7.7, 13.7 and 10.4 μm for hepg2, smmc-7721 and bel-7402 cell line, respectively (after 24h treatment)

References

[1] wang f,he l,dai wq,xu yp,wu d,lin cl,wu sm,cheng p,zhang y,shen m,wang cf,lu j,zhou yq,xu xf,xu l,guo cy. salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. plos one.2012;7(12):e50638.

Salinomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Salinomycin Suppliers

Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17840
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14059
Advantage
65
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2895
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4648
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Simagchem Corp.
Tel
86 592 2680277
Fax
0086 592 2680237
Email
sale@simagchem.com
Country
China
ProdList
430
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
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View Lastest Price from Salinomycin manufacturers

shandong perfect biotechnology co.ltd
Product
Salinomycin 53003-10-4
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
100kg
Release date
2023-08-09
Hebei Duling International Trade Co. LTD
Product
Salinomycin 53003-10-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-03-24
Hebei Yanxi Chemical Co., Ltd.
Product
Salinomycin 53003-10-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-09-25

53003-10-4, SalinomycinRelated Search:


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