ChemicalBook > CAS DataBase List > Salinomycin

Salinomycin

Product Name: Salinomycin
CAS No.: 53003-10-4
Chemical Name: Salinomycin
Synonyms: SALINOMYCIN SODIUM;coxistac;Procoxacin;Salinomycin;Salinomycin;SALINOMYCIN 90%;Antibiotic-61477;Salinomycin, >98%;SALINOMYCIN GRANULE;SalinoMycin 12% 24%
CBNumber: CB9161784
Molecular Formula: C42H70O11
Formula Weight: 751
MOL File: 53003-10-4.mol

Less

Salinomycin Property

Melting point:: 112.5-113.5 °C(lit.)
Boiling point:: 839.2±65.0 °C(Predicted)
alpha: D25 -63° (c = 1 in ethanol)
Density: 1.18±0.1 g/cm3(Predicted)
Flash point:: >110°(230°F)
storage temp.: Sealed in dry,2-8°C
solubility: insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO
form: White solid
pka: 6.4 (DMF)
color: White to light yellow
biological source: Streptomyces albus
optical activity: -6325 (cl, ethanol)
Water Solubility: Soluble in methanol. Insoluble in water
Merck: 13,8415
Stability:: Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.
LogP: 5.596 (est)
CAS DataBase Reference: 53003-10-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: T,Xi
Risk Statements: 25-36/37/38
Safety Statements: 45-36-26
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: VO8620000
F: 10
HazardClass: 6.1(a)
PackingGroup: II
Hazardous Substances Data: 53003-10-4(Hazardous Substances Data)
Toxicity: LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4526
Product name: Salinomycin
Purity: from Streptomyces albus, ≥98% (HPLC)
Packaging: 5mg
Price: $243
Updated: 2025/07/31

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 5mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 50mg
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 100mg
Price: $163
Updated: 2024/03/01

Less

Salinomycin Chemical Properties,Usage,Production

Description

Salinomycin was found in the culture mycelium of Streptomyces albus by Otake et al. of the University of Tokyo in 1973. Like other polyether ionophore antibiotics, it shows activity against gram-positive bacteria, fungi, and Coccidium. Salinomycin has been used as a feed additive to protect poultry against coccidial infections.

Chemical Properties

solid

Uses

antibacterial

Uses

Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.

Uses

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44⁺CD24^- mesenchymal-like subpopulation within breast carcinomas.

Definition

ChEBI: Salinomycin is a polyketide and a spiroketal. It has a role as an animal growth promotant and a potassium ionophore.

General Description

Chemical structure: polyether

Biological Activity

salinomycin (sal), which is a polyether ionophore antibiotic from streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with abc drug transporters, the wnt/β-catenin signaling pathway, or other pathways.

Biochem/physiol Actions

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.

in vitro

several hepatocellular carcinoma (hcc) cell lines were treated with sal. results showed that sal inhibited proliferation and decreased pcna levels. cell cycle analysis showed that sal caused cell cycle arrest in different phases. sal induced apoptosis as characterized by an increase in the bax/bcl-2 ratio. compared to control, β-catenin expression was down-regulated by sal treatment significantly. the ca2+ concentration in hcc cells was examined by flow cytometry and it was found that higher ca2+ concentrations were observed in sal treatment groups [1].

in vivo

the in vivo anti-tumor effect of sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in sal-treated groups decreased. immunohistochemistry and tunel staining also demonstrated that sal could in vivo inhibit proliferation and induced apoptosis [1].

IC 50

7.7, 13.7 and 10.4 μm for hepg2, smmc-7721 and bel-7402 cell line, respectively (after 24h treatment)

References

[1] JOHANNES KLOSE. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.[J]. PLoS ONE, 2019: e0211916. DOI:10.1371/journal.pone.0211916.
[2] DESHENG LU. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011: 13253-13257. DOI:10.1073/pnas.1110431108.
[3] LONGQIN WANG . Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression[J]. Biomaterials, 2025, 325: Article 123632. DOI:10.1016/j.biomaterials.2025.123632.
[4] FAN WANG. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo.[J]. PLoS ONE, 2012: e50638. DOI:10.1371/journal.pone.0050638.

Salinomycin Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Salinomycin Suppliers

China 240 Europe 2 Germany 1 India 3 Japan 1 Switzerland 1 United Kingdom 7 United States 35 Global 290

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Simagchem Corp.

Tel: 86 592 2680277
Fax: 0086 592 2680237
Email: sale@simagchem.com
Country: China
ProdList: 430
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Wuhan DKY Technology Co.,Ltd.

Tel: 027-27-81302488 15972195220
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 1758
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9279
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Hubei Prosperity Galaxy Chemical CO,.Ltd.

Tel: 027-83856981
Fax: 15807174745
Email: 1498703467@qq.com
Country: China
ProdList: 244
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Hubei Bangsun Chemical Co., Ltd.

Tel: 18171081685
Fax: 027-83219882
Email: 2834045742@qq.com
Country: China
ProdList: 313
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Shanghai Linka Biotechnology Co., Ltd.

Tel: 18301977208
Fax: qq2126935757
Email: 2126935757@qq.com
Country: China
ProdList: 214
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Shanghai Orgchem Co.,Ltd.

Tel: +86-21-5877 1921
Fax: +86-21-5877 1925
Email: info@chemofchina.com
Country: China
ProdList: 9653
Advantage: 55

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Foshan DaoQi Biological Co., Ltd.

Tel: 18062666947
Fax: 18062666959
Email: 2355880548@qq.com
Country: China
ProdList: 4228
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10267
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Wuhan Mengqi Technology Co., Ltd.

Tel: 027-83232706 15871702139
Email: 3454407469@qq.com
Country: China
ProdList: 662
Advantage: 58

Zhejiang Zetian Fine Chemical Co., Ltd.

Tel: 0571-87682782 18957127338
Fax: QQ800182836
Email: sales@zetchem.com
Country: China
ProdList: 567
Advantage: 58

Hebei Chuanghai Biotechnology Co,.LTD

Tel: +86-13131129325
Fax: 86-0311-66562153
Email: sales1@chuanghaibio.com
Country: China
ProdList: 5249
Advantage: 58

Finetech Industry Limited

Tel: +86-27-8746-5837 +8619945049750
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9629
Advantage: 58

Less

View Lastest Price from Salinomycin manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Salinomycin 53003-10-4
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Salinomycin 53003-10-4
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-27

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Salinomycin 53003-10-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-28

53003-10-4, SalinomycinRelated Search:

Ethyl cyanoacetate Ethanol Trinexapac-ethyl Ethyl acetate CHLOROPHOSPHONAZO III Ethyl acrylate ISOXADIFEN-ETHYL Ethylparaben Ethyl propiolate Corydaline Sancycline Salicylanilide Bengenin Sodium stearate 3-ETHYL-4-OCTANONE cis-9-Tricosene CIS-3-NONEN-1-OL Salinomycin, 4-methyl-, (4S)-

SALINOMYCIN SODIUM

coxistac

SALINOMYCIN GRANULE

Salinomycin Premix 12%

SALINOMYCIN FROM STREPTOMYCES ALBUS

SALINOMYCIN 90%

SV sodium salt,2,5 salinomycin hydrate

(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid

Salinomycin

Antibiotic-61477

SalinoMycin(Procoxacin)

SalinoMycin 12% 24%

Procoxacin

Eustin, AHR 3096, K 364, 61477

Salinomycin Solution, 100ppm

Salinomycin, >98%

Salinomycin USP/EP/BP

SALINOMYCIN SODIUM PREMIX （10%, 12%, 45%）

99% purity Salinomycin

Salinomycin (10mM in DMSO)

(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid

SalinomycinQ: What is Salinomycin Q: What is the CAS Number of Salinomycin Q: What is the storage condition of Salinomycin Q: What are the applications of Salinomycin

Salinomycin in Methanol

Salinomycin in Acetonitrile

Salinomycin

53003-10-4

C42H69NaO11

C42H69O11Na

C42H70O11

Antibiotics N-S

Antibiotics A to Z

Antibiotics

BioChemical

KOKCISAN

Antibacterial

Antibiotics

Antibiotics A to

Antibiotics N-SAntibiotics

Chemical Structure Class

L - ZAntibiotics

Mechanism of Action

Monovalent Ion Channels

Polyethers

Inhibitors

Interferes with Cell Membrane Permeability (Ionophores)Voltage-gated Ion Channels

IonophoresSpectrum of Activity

53003-10-4