Sancycline

Product Name: Sancycline
CAS No.: 808-26-4
Chemical Name: Sancycline
Synonyms: Sancycline Hydrochloride;(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;CS-676;GS 2147;Bonomycin;NSC-51812;Norcycline;SANCYCLINE;Sancyclinum;808-26-4 Sancycline
CBNumber: CB0420370
Molecular Formula: C21H22N2O7
Formula Weight: 414.41
MOL File: 808-26-4.mol

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Sancycline Property

Melting point:: 224-2280C (dec)
Boiling point:: 750.9±60.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.50±1.00(Predicted)
color: Beige to Dark Beige
Stability:: Hygroscopic
InChIKey: XDVCLKFLRAWGIT-ADOAZJKMSA-N
SMILES: C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C=CC=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
CAS DataBase Reference: 808-26-4

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SBR00097
Product name: Sancycline
Purity: ≥95% (H-NMR), powder
Packaging: 1 unit
Price: $340
Updated: 2025/07/31

Sigma-Aldrich

Product number: PH000287
Product name: (4S,4AS,5AR,12AS)-4-(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-2-NAPHTHACENECARBOXAMIDE
Purity: AldrichCPR
Packaging: 1MG
Price: $172
Updated: 2023/06/20

Cayman Chemical

Product number: 23100
Product name: Sancycline
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23100
Product name: Sancycline
Purity: ≥98%
Packaging: 25mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 23100
Product name: Sancycline
Purity: ≥98%
Packaging: 100mg
Price: $365
Updated: 2024/03/01

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Sancycline Chemical Properties,Usage,Production

Description

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC₉₀s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED₅₀ values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

Chemical Properties

Yellow Solid

Uses

A semi-synthetic antibiotic related to tetracycline

Uses

Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

Uses

Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).

Definition

ChEBI: Sancycline is a member of tetracyclines.

brand name

Bonomycin (Pfizer).

References

[1] J. R. D. MCCORMICK. The 6-Deoxytetracyclines.1 Further Studies on the Relationship between Structure and Antibacterial Activity in the Tetracycline Series[J]. Journal of the American Chemical Society, 1960, 82 13: 3381-3386. DOI: 10.1021/ja01498a037
[2] H M WEXLER S M F E Molitoris. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria.[J]. Antimicrobial Agents and Chemotherapy, 1994, 38 10: 2513-2515. DOI: 10.1128/aac.38.10.2513
[3] R T TESTA. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.[J]. Antimicrobial Agents and Chemotherapy, 1993, 37 11: 2270-2277. DOI: 10.1128/aac.37.11.2270

Sancycline Preparation Products And Raw materials

Raw materials

Preparation Products

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Sancycline Suppliers

Canada 2 China 182 Germany 2 India 7 Italy 1 United Kingdom 3 United States 16 Global 213

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824; 13184580281
Fax: 400-880-2824
Email: hj@ruiweier.cn
Country: China
ProdList: 2686
Advantage: 58

Hubei Aiputi Bioengineering Co., Ltd.

Tel: 17762444226
Email: d17762444226@163.com
Country: China
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Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
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Cdreamlab (Hubei) Technology Co., LTD

Tel: 18062399888
Email: service@cdreamlab.com
Country: China
ProdList: 128
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Nanjing Vcare PharmaTech Co., Ltd

Tel: 025-58741518 13327700685
Email: sales@vcarepharmatech.com
Country: China
ProdList: 495
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Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
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Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
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S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
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View Lastest Price from Sancycline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Sancycline 808-26-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-16

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Minocycline EP Impurity B 808-26-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2024-05-22

R&D Scientific Inc.

Product: Sancycline 808-26-4
Price: US $2500.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 5 Kg
Release date: 2024-03-27

808-26-4, SancyclineRelated Search:

Oxytetracycline hydrochloride Minocycline Metacycline hydrochloride Minocycline hydrochloride 3-Dimethylaminopropylamine Cyclosporin A Salicylanilide Salinomycin Nortropinone hydrochloride Deslanoside Tetracycline hydrochloride DOXYCYCLINE HYDROCHLORIDE Doxycycline meclocycline METHACYCLINE HYDROCHLORIDE pipacycline 9-Amino minocycline hydrochloride Chlortetracycline

SANCYCLINE

(4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxamide

6-Demethyl-6-deoxytetracycline

Bonomycin

GS 2147

Norcycline

Sancycline Hydrochloride

(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide

NSC-51812

Minocycline IMpurity B

2-NaphthacenecarboxaMide,4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)-

(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

6-DeMethyl-6-deoxytetracycline, BonoMycin, Norcycline

BONOMYCIN; NORCYCLINE;6-DEMETHYL-6-DEOXYTETRACYCLINE

Minocycline EP Impurity B/Sancycline/(4S,5aS,8Z,10E,14aS)-4-(dimethylamino)-3,11,14,14a-tetrahydroxy-1,13-dioxo-1,4,4a,5,5a,6,7,12,13,14a-decahydrocyclodeca[b]naphthalene-2-carboxamide

CS-676

Sancycline in stock Factory

Sancycline (Bonomycin

Sancyclinum

Minocycline EP Impurity B (Sancycline)

SancyclineQ: What is Sancycline Q: What is the CAS Number of Sancycline Q: What is the storage condition of Sancycline Q: What are the applications of Sancycline

808-26-4 Sancycline

(4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Sancycline, 10 mM in DMSO

Minocycline E Impurity B

Sarecycline Impurity 25

808-26-4

208538-73-6

C21H22N2O7

C21H23ClN2O7

Intermediates & Fine Chemicals

Pharmaceuticals