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Sancycline

Product Name
Sancycline
CAS No.
808-26-4
Chemical Name
Sancycline
Synonyms
Sancycline Hydrochloride;(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;CS-676;GS 2147;Bonomycin;NSC-51812;Norcycline;SANCYCLINE;Sancyclinum;808-26-4 Sancycline
CBNumber
CB0420370
Molecular Formula
C21H22N2O7
Formula Weight
414.41
MOL File
808-26-4.mol
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Sancycline Property

Melting point:
224-2280C (dec)
Boiling point:
750.9±60.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
4.50±1.00(Predicted)
color 
Beige to Dark Beige
Stability:
Hygroscopic
InChIKey
XDVCLKFLRAWGIT-ADOAZJKMSA-N
SMILES
C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C=CC=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
CAS DataBase Reference
808-26-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SBR00097
Product name
Sancycline
Purity
≥95% (H-NMR), powder
Packaging
1 unit
Price
$340
Updated
2025/07/31
Sigma-Aldrich
Product number
PH000287
Product name
(4S,4AS,5AR,12AS)-4-(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-2-NAPHTHACENECARBOXAMIDE
Purity
AldrichCPR
Packaging
1MG
Price
$172
Updated
2023/06/20
Cayman Chemical
Product number
23100
Product name
Sancycline
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23100
Product name
Sancycline
Purity
≥98%
Packaging
25mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
23100
Product name
Sancycline
Purity
≥98%
Packaging
100mg
Price
$365
Updated
2024/03/01
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Sancycline Chemical Properties,Usage,Production

Description

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

Chemical Properties

Yellow Solid

Uses

A semi-synthetic antibiotic related to tetracycline

Uses

Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

Uses

Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).

Definition

ChEBI: Sancycline is a member of tetracyclines.

brand name

Bonomycin (Pfizer).

References

[1] J. R. D. MCCORMICK. The 6-Deoxytetracyclines.1 Further Studies on the Relationship between Structure and Antibacterial Activity in the Tetracycline Series[J]. Journal of the American Chemical Society, 1960, 82 13: 3381-3386. DOI: 10.1021/ja01498a037
[2] H M WEXLER  S M F  E Molitoris. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria.[J]. Antimicrobial Agents and Chemotherapy, 1994, 38 10: 2513-2515. DOI: 10.1128/aac.38.10.2513
[3] R T TESTA. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.[J]. Antimicrobial Agents and Chemotherapy, 1993, 37 11: 2270-2277. DOI: 10.1128/aac.37.11.2270

Sancycline Preparation Products And Raw materials

Raw materials

Preparation Products

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Sancycline Suppliers

Canada 2 China 184 Germany 2 India 7 Italy 1 United Kingdom 3 United States 16 Global 215
Euticals S.p.A.
Tel
--
Fax
--
Email
info@euticals.com
Country
Italy
ProdList
86
Advantage
50
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View Lastest Price from Sancycline manufacturers

Allsino Pharmaceutical Co.,Ltd
Product
Sancycline 808-26-4
Price
US $0.00-0.00/g
Min. Order
5g
Purity
85.0%
Supply Ability
g~kg
Release date
2025-12-10
Shaanxi Dideu New Materials Co. Ltd
Product
Sancycline 808-26-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-16
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Minocycline EP Impurity B 808-26-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2024-05-22

808-26-4, SancyclineRelated Search:

Oxytetracycline hydrochloride Minocycline Metacycline hydrochloride Minocycline hydrochloride 3-Dimethylaminopropylamine Cyclosporin A Salicylanilide Salinomycin Nortropinone hydrochloride Deslanoside Tetracycline hydrochloride DOXYCYCLINE HYDROCHLORIDE Doxycycline meclocycline METHACYCLINE HYDROCHLORIDE pipacycline 9-Amino minocycline hydrochloride Chlortetracycline

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  • (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
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  • C21H22N2O7
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