ChemicalBook > CAS DataBase List > Famoxadone

Famoxadone

Product Name
Famoxadone
CAS No.
131807-57-3
Chemical Name
Famoxadone
Synonyms
JE 874;Famoxate;Famoxadon;CCharisma;IN-JE 874;DPX-JE 874;FAMOXADONE;FaMoxadone solutio;famoxadone solution;C13399000 Famoxadone
CBNumber
CB8439206
Molecular Formula
C22H18N2O4
Formula Weight
374.39
MOL File
131807-57-3.mol
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Famoxadone Property

Melting point:
140.3~141.8℃
Boiling point:
491.3±55.0 °C(Predicted)
Density 
1.327±0.06 g/cm3(Predicted)
vapor pressure 
6.4 x 10-7 Pa (20 °C)
Flash point:
2 °C
storage temp. 
0-6°C
solubility 
DMSO: 100 mg/mL (267.10 mM)
Water Solubility 
0.243 mg-1 (pH 5), 0.011 mg l-1 (pH 7) at 20 °C
pka
0.63±0.40(Predicted)
form 
Solid:particulate/powder
color 
White to yellow
LogP
4.65-5.08 at 20℃ and pH4-7
Surface tension
73mN/m at 90μg/L and 20.4℃
EPA Substance Registry System
Famoxadone (131807-57-3)
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Safety

Hazard Codes 
Xn,N,F
Risk Statements 
48/22-50/53-36-20/21/22-11
Safety Statements 
46-60-61-36-26-16-36/37
RIDADR 
UN1648 3/PG 2
WGK Germany 
2
Hazardous Substances Data
131807-57-3(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33495
Product name
Famoxadone solution
Purity
100?μg/mL in acetonitrile, PESTANAL?, analytical standard
Packaging
2ML
Price
$86.2
Updated
2024/03/01
TRC
Product number
F102300
Product name
Famoxadone
Packaging
1g
Price
$145
Updated
2021/12/16
TRC
Product number
F102300
Product name
Famoxadone
Packaging
10g
Price
$305
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
51328
Product name
Famoxadone
Packaging
1g
Price
$620
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
51328
Product name
Famoxadone
Packaging
50g
Price
$875
Updated
2021/12/16
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Famoxadone Chemical Properties,Usage,Production

Description

Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.

Chemical Properties

Brown Solid

Uses

Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).

Uses

Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.

Uses

Agricultural fungicide.

Definition

ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.

Agricultural Uses

Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.

Trade name

DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®

Pharmacology

Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).

Metabolic pathway

Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.

Degradation

Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT50 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT50 values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT50 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).

Toxicity evaluation

Famoxadone has an acute oral LD50 > 5,000 mg/kg and an acute percutaneous LD50 > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.

Famoxadone Preparation Products And Raw materials

Raw materials

Preparation Products

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Famoxadone Suppliers

Wuhan Linglingjiu Biotechnology Co., Ltd
Tel
15623309010
Email
1287744812@qq.com
Country
China
ProdList
1657
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Rudong Zhongyi Chemical Co., Ltd
Tel
13306234115
Fax
+86-0513-84819568
Email
jszyzj@zhongyichem.com
Country
China
ProdList
36
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
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View Lastest Price from Famoxadone manufacturers

qingdao trust agri chemical co.,ltd
Product
Famoxadone 131807-57-3
Price
US $0.00/KG
Min. Order
100KG
Purity
98
Supply Ability
200TONS
Release date
2024-07-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
Famoxadone 131807-57-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Famoxadone 131807-57-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

131807-57-3, FamoxadoneRelated Search:


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  • API
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