Famoxadone

ChemicalBook > CAS DataBase List > Famoxadone

Product Name: Famoxadone
CAS No.: 131807-57-3
Chemical Name: Famoxadone
Synonyms: JE 874;Famoxate;Famoxadon;CCharisma;IN-JE 874;DPX-JE 874;FAMOXADONE;FaMoxadone solutio;famoxadone solution;C13399000 Famoxadone
CBNumber: CB8439206
Molecular Formula: C22H18N2O4
Formula Weight: 374.39
MOL File: 131807-57-3.mol

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Famoxadone Property

Melting point:: 140.3～141.8℃
Boiling point:: 491.3±55.0 °C(Predicted)
Density: 1.327±0.06 g/cm3(Predicted)
vapor pressure: 6.4 x 10^-7 Pa (20 °C)
Flash point:: 2 °C
storage temp.: 0-6°C
solubility: DMSO: 100 mg/mL (267.10 mM)
Water Solubility: 0.243 mg^-1 (pH 5), 0.011 mg l^-1 (pH 7) at 20 °C
pka: 0.63±0.40(Predicted)
form: Solid:particulate/powder
color: White to yellow
LogP: 4.65-5.08 at 20℃ and pH4-7
Surface tension: 73mN/m at 90μg/L and 20.4℃
EPA Substance Registry System: Famoxadone (131807-57-3)

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Safety

Hazard Codes: Xn,N,F
Risk Statements: 48/22-50/53-36-20/21/22-11
Safety Statements: 46-60-61-36-26-16-36/37
RIDADR: UN1648 3/PG 2
WGK Germany: 2
Hazardous Substances Data: 131807-57-3(Hazardous Substances Data)
Toxicity: LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33495
Product name: Famoxadone solution
Purity: 100?μg/mL in acetonitrile, PESTANAL?, analytical standard
Packaging: 2ML
Price: $86.2
Updated: 2024/03/01

TRC

Product number: F102300
Product name: Famoxadone
Packaging: 1g
Price: $145
Updated: 2021/12/16

TRC

Product number: F102300
Product name: Famoxadone
Packaging: 10g
Price: $305
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 51328
Product name: Famoxadone
Packaging: 1g
Price: $620
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 51328
Product name: Famoxadone
Packaging: 50g
Price: $875
Updated: 2021/12/16

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Famoxadone Chemical Properties,Usage,Production

Description

Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.

Chemical Properties

Brown Solid

Uses

Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).

Uses

Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.

Uses

Agricultural fungicide.

Definition

ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.

Agricultural Uses

Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.

Trade name

DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®

Pharmacology

Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).

Metabolic pathway

Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.

Degradation

Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT₅₀ 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT₅₀ values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT₅₀ 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).

Toxicity evaluation

Famoxadone has an acute oral LD₅₀ > 5,000 mg/kg and an acute percutaneous LD₅₀ > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.

Famoxadone Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 4'-Phenoxyacetophenone

Preparation Products

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View Lastest Price from Famoxadone manufacturers

qingdao trust agri chemical co.,ltd

Product: Famoxadone 131807-57-3
Price: US $0.00/KG
Min. Order: 100KG
Purity: 98
Supply Ability: 200TONS
Release date: 2024-07-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Famoxadone 131807-57-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Famoxadone 131807-57-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

131807-57-3, FamoxadoneRelated Search:

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3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione

5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione

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5-Methyl-5-(4-phenoxyphenyl)-3-(phenylamino)oxazolidine-2,4-dione

famoxadone (bsi, pa iso)

famoxadone solution

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famoxadone 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione

3-pheny-lamino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione

CCharisma

DPX-JE 874

IN-JE 874

JE 874

FaMoxadone solutio

2,4-Oxazolidinedione,5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-

FAMOXADONE

3-ANILINO-5-METHYL-5-(4-PHENOXYPHENYL)OXAZOLIDINE-2,4-DIONE

Famoxadone Solution, 1000ppm

FamoxadoneSolution,100mg/L,1ml

Famoxadone Reference Material

Famoxadon@1000 μg/mL in Acetonitrile

Famoxadon @100 μg/mL in Acetonitrile

Famoxadone Solution in Methanol, 100μg/mL

Fensulfothion Impurity 8

Famoxadone Solution in Methanol

C13399000 Famoxadone

L13399000CY FamoxadonE10μg/mLin Cyclohexane

Famoxadone in Acetonitrile

131807-57-3

13180-57-3

API

agrochemical

Fungicide