Famoxadone

ChemicalBook > CAS DataBase List > Famoxadone

Product Name: Famoxadone
CAS No.: 131807-57-3
Chemical Name: Famoxadone
Synonyms: JE 874;Famoxate;Famoxadon;CCharisma;IN-JE 874;DPX-JE 874;FAMOXADONE;FaMoxadone solutio;famoxadone solution;famoxadone (bsi, pa iso)
CBNumber: CB8439206
Molecular Formula: C22H18N2O4
Formula Weight: 374.39
MOL File: 131807-57-3.mol

Less

Famoxadone Property

Melting point:: 140.3～141.8℃
Boiling point:: 491.3±55.0 °C(Predicted)
Density: 1.327±0.06 g/cm3(Predicted)
vapor pressure: 6.4 x 10^-7 Pa (20 °C)
Flash point:: 2 °C
storage temp.: 0-6°C
solubility: DMSO: 100 mg/mL (267.10 mM)
Water Solubility: 0.243 mg^-1 (pH 5), 0.011 mg l^-1 (pH 7) at 20 °C
pka: 0.63±0.40(Predicted)
form: Solid:particulate/powder
LogP: 4.65-5.08 at 20℃ and pH4-7
Surface tension: 73mN/m at 90μg/L and 20.4℃
EPA Substance Registry System: Famoxadone (131807-57-3)

Less

Safety

Hazard Codes: Xn,N,F
Risk Statements: 48/22-50/53-36-20/21/22-11
Safety Statements: 46-60-61-36-26-16-36/37
RIDADR: UN1648 3/PG 2
WGK Germany: 2
Hazardous Substances Data: 131807-57-3(Hazardous Substances Data)
Toxicity: LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33495
Product name: Famoxadone solution
Purity: 100?μg/mL in acetonitrile, PESTANAL?, analytical standard
Packaging: 2ML
Price: $86.2
Updated: 2024/03/01

TRC

Product number: F102300
Product name: Famoxadone
Packaging: 1g
Price: $145
Updated: 2021/12/16

TRC

Product number: F102300
Product name: Famoxadone
Packaging: 10g
Price: $305
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 51328
Product name: Famoxadone
Packaging: 1g
Price: $620
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 51328
Product name: Famoxadone
Packaging: 50g
Price: $875
Updated: 2021/12/16

Less

Famoxadone Chemical Properties,Usage,Production

Description

Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.

Chemical Properties

Brown Solid

Uses

Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).

Uses

Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.

Uses

Agricultural fungicide.

Definition

ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.

Agricultural Uses

Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.

Trade name

DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®

Pharmacology

Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).

Metabolic pathway

Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.

Degradation

Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT₅₀ 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT₅₀ values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT₅₀ 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).

Toxicity evaluation

Famoxadone has an acute oral LD₅₀ > 5,000 mg/kg and an acute percutaneous LD₅₀ > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.

Famoxadone Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 4'-Phenoxyacetophenone

Preparation Products

Less

Famoxadone Suppliers

Canada 1 China 136 France 2 Germany 1 India 2 Japan 2 South Korea 1 Switzerland 1 United Kingdom 3 United States 14 Global 163

Wuhan Linglingjiu Biotechnology Co., Ltd

Tel: 15623309010
Email: 1287744812@qq.com
Country: China
ProdList: 1657
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Beijing HwrkChemical Technology Co., Ltd

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7639
Advantage: 55

Rudong Zhongyi Chemical Co., Ltd

Tel: 13306234115
Fax: +86-0513-84819568
Email: jszyzj@zhongyichem.com
Country: China
ProdList: 36
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 2002
Advantage: 62

Shanghai Run-Biotech Co., Ltd.

Tel: 021-57171705 13817537615
Fax: QQ3095748324
Email: sales@run-biotech.com
Country: China
ProdList: 2559
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17993
Advantage: 56

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

Shenzhen Nexconn Pharmatechs Ltd.

Tel: 0755-89396905
Email: admin@nexconn.com
Country: China
ProdList: 304
Advantage: 55

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5917
Advantage: 50

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4515
Advantage: 55

Hubei Kangbaotai Finechem Co., Ltd.

Tel: +86 (27) 8778653
Fax: +86 (27) 8773-8652
Email: 13720228325@163.com
Country: China
ProdList: 337
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 551-65418679 15837135945
Fax: 0551-65418697
Email: info@tnjchem.com
Country: China
ProdList: 1889
Advantage: 62

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9947
Advantage: 58

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 3180
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6120
Advantage: 58

Shanghai Vigor Biotechnology Co., Ltd.

Tel: info@vigorchem.cn 1801605789
Fax: QQ：1801605789
Country: China
ProdList: 169
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1991
Advantage: 55

Wuhan Magic Biological Technology Co., Ltd.

Tel: 18872289958、027-52304252、3400508168
Fax: 027-52304252
Email: 3400508168@qq.com
Country: China
ProdList: 1910
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3982
Advantage: 58

Shanghai Orgchem Co.,Ltd.

Tel: +86-21-5877 1921
Fax: +86-21-5877 1925
Email: info@chemofchina.com
Country: China
ProdList: 9661
Advantage: 55

Hubei ZhengXingyuan Chemical Co., Ltd.

Tel: 027-87879183,027-87633098 15207106154
Fax: 027-87877281
Email: 2905723734@qq.com
Country: China
ProdList: 304
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9303
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15085
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 1997
Advantage: 64

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17997
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9907
Advantage: 58

Zheda Panaco (Shandong) Chemical Enginering Co., Ltd.

Tel: 0530-8865559 13805730994;
Fax: 0530-8850005
Email: panaco@zhedachem.com
Country: China
ProdList: 172
Advantage: 58

Foshan DaoQi Biological Co., Ltd.

Tel: 18062666947
Fax: 18062666959
Email: 2355880548@qq.com
Country: China
ProdList: 4229
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920564737
Email: sales@heowns.com
Country: China
ProdList: 20632
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Beijing altar ink quality inspection technology co., LTD

Tel: 010-52889049
Email: 2250970673@qq.com
Country: CHINA
ProdList: 1133
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 10066
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 56056
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23556
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

Baoji Guokang Bio-Technology Co., Ltd.

Tel: 0917-3909592 13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9327
Advantage: 58

Longyan Tianhua Biological Technology Co., Ltd

Tel: 0086 18039857276 18039857276
Country: CHINA
ProdList: 2783
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

Less

View Lastest Price from Famoxadone manufacturers

Hebei Duling International Trade Co. LTD

Product: Famoxadone 131807-57-3
Price: US $9.90/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2022-10-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Famoxadone 131807-57-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Famoxadone 131807-57-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

131807-57-3, FamoxadoneRelated Search:

Thiophanate-methyl Methyl acetate Tribenuron methyl Fenoxaprop-P ISOXAFLUTOLE Kresoxim-methyl Sulfamethoxazole 3,4'-DIAMINODIPHENYLMETHANE METSULFURON METHYL Pirimiphos-methyl 4-Methoxyphenylacetone Phenyltriethoxysilane 2-(Trifluoromethoxy)aniline Diphenyldimethoxysilane Methyl salicylate Isoxazole Methyl Actidione

3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione

5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione

Famoxate

Semicarbacide Hydrochloride, Vetranal

5-Methyl-5-(4-phenoxyphenyl)-3-(phenylamino)oxazolidine-2,4-dione

famoxadone (bsi, pa iso)

famoxadone solution

Famoxadon

Famoxadone 100mg [131807-57-3]

famoxadone 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione

3-pheny-lamino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione

CCharisma

DPX-JE 874

IN-JE 874

JE 874

FaMoxadone solutio

2,4-Oxazolidinedione,5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-

FAMOXADONE

3-ANILINO-5-METHYL-5-(4-PHENOXYPHENYL)OXAZOLIDINE-2,4-DIONE

Famoxadone Solution, 1000ppm

FamoxadoneSolution,100mg/L,1ml

Famoxadone Reference Material

Famoxadon@1000 μg/mL in Acetonitrile

Famoxadon @100 μg/mL in Acetonitrile

Famoxadone Solution in Methanol, 100μg/mL

Fensulfothion Impurity 8

Famoxadone Solution in Methanol

131807-57-3

13180-57-3

API

agrochemical

Fungicide