2-Chlorobenzothiazole
- Product Name
- 2-Chlorobenzothiazole
- CAS No.
- 615-20-3
- Chemical Name
- 2-Chlorobenzothiazole
- Synonyms
- 2-CHLOROBENZO[D]THIAZOLE;usafek-2784;USAF ek-2784;orobenzothiazoL;2-Chlorbenzothiazol;2-chloro-benzothiazol;2-Chlorobenzophiazole;2-CHLOROBENZOTHIAZOLE;2-CHLOROBENZOTHIOAZOLE;Benzothiazole, 2-chloro-
- CBNumber
- CB9762750
- Molecular Formula
- C7H4ClNS
- Formula Weight
- 169.63
- MOL File
- 615-20-3.mol
2-Chlorobenzothiazole Property
- Melting point:
- 21-23 °C (lit.)
- Boiling point:
- 141 °C/30 mmHg (lit.)
- Density
- 1.303 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.637(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -0.23±0.10(Predicted)
- form
- Liquid
- Specific Gravity
- 1.3711.303
- color
- Clear yellow to yellow-brownish
- Water Solubility
- insoluble
- BRN
- 116316
- CAS DataBase Reference
- 615-20-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzothiazole, 2-chloro-(615-20-3)
- EPA Substance Registry System
- 2-Chlorobenzothiazole (615-20-3)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22-20/21/22
- Safety Statements
- 23-24/25-37/39-26-36
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- DL3150000
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29342080
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 167576
- Product name
- 2-Chlorobenzothiazole
- Purity
- 99%
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- 167576
- Product name
- 2-Chlorobenzothiazole
- Purity
- 99%
- Packaging
- 25g
- Price
- $114.8
- Updated
- 2025/07/31
- Product number
- C0332
- Product name
- 2-Chlorobenzothiazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- C0332
- Product name
- 2-Chlorobenzothiazole
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $317
- Updated
- 2025/07/31
- Product number
- C364608
- Product name
- 2-Chloro-1,3-benzothiazole
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
2-Chlorobenzothiazole Chemical Properties,Usage,Production
Chemical Properties
CLEAR YELLOW TO YELLOW-BROWNISH LIQUID
Uses
2-Chloro-1,3-benzothiazole is used in the synthesis of CBTs which are good building blocks for bioluminescent compounds for imaging.
Uses
2-Chlorobenzothiazole was used in the synthesis of:
- (RS)- and (S)-lubeluzole
- (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
- 4H-thieno[2′,3′:4,5]pyrimido[2,1-b]benzothiazole derivatives
Synthesis
95-16-9
615-20-3
The general procedure for the synthesis of 2-chlorobenzothiazole from benzothiazole was as follows: benzothiazole (1 mmol, 135.9 mg) and carbon tetrachloride (1.1 mmol, 169.2 mg) were placed in a 10 mL round bottom flask. 5 mL of N,N-dimethylformamide and sodium tert-butoxide (4.0 mmol, 384.4 mg) were added to the reaction system and stirred thoroughly to ensure that the reactants were homogeneously mixed. The reaction was carried out at room temperature for 3 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane. The organic phase was separated and dried with anhydrous sodium sulfate. Subsequently, the dichloromethane was removed by rotary evaporator to obtain the crude product. The crude product was purified by silica gel column chromatography using a mixed solvent of petroleum ether and ethyl acetate as eluent (30:1, v/v). 2-Chlorobenzothiazole (brown oily liquid, 149.2 mg) was finally obtained in 88% yield.
Purification Methods
It is purified by fractional distillation in vacuo. The 2-chloro-3-methylbenzothiazolinium 2,4-dinitrobenzenesulfonate crystallises from Ac2O, m 162-163o(dec). [Young & Amstutz J Am Chem Soc 73 4773 1951, Brower et al. J Org Chem 19 1830 1954, Hunter & Jones J Chem Soc 2190 1930, Beilstein 27 H 44, 27 II 18, 27 III/IV 1072.]
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 6, p. 886 - 890
[2] Patent: CN107501023, 2017, A. Location in patent: Paragraph 0063; 0064
[3] Organic Letters, 2009, vol. 11, # 2, p. 421 - 423
[4] Journal of Organic Chemistry, 2009, vol. 74, # 21, p. 8309 - 8313
[5] Chemische Berichte, 1880, vol. 13, p. 16
2-Chlorobenzothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chlorobenzothiazole manufacturers
- Product
- 2-Chlorobenzothiazole 615-20-3
- Price
- US $10.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-28
- Product
- 2-Chlorobenzothiazole 615-20-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 2-Chlorobenzothiazole 615-20-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-03