(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

Product Name: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
CAS No.: 844639-57-2
Chemical Name: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
Synonyms: TM30089;CS-1157;TM30089 Racemate;CAY10471 Racemate;TM 30089;TM-30089;TM30089 (CAY10471);CAY10471 Racemate, 10 mM in DMSO;9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]MethylaMino]-1,2,3,4-tetrahydro-;(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID;CAY 10471,CAY10471,TM30089,Inhibitor,CAY-10471,TM 30089,TM-30089,CAY10471 Racemate,inhibit,Prostaglandin Receptor,CAY-10471 Racemate
CBNumber: CB02448675
Molecular Formula: C21H21FN2O4S
Formula Weight: 416.47
MOL File: 844639-57-2.mol

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(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Property

Melting point:: 165-173℃ (dichloromethane )
Boiling point:: 639.1±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 150 mg/mL (360.17 mM)
form: Solid
pka: 4.33±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2743
Product name: TM30089
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $124
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2743
Product name: TM30089
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $495
Updated: 2024/03/01

Biorbyt Ltd

Product number: orb181174
Product name: TM30089
Purity: >98%
Packaging: 100mg
Price: $578
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BIO0000169
Product name: TM-30089
Purity: 95.00%
Packaging: 10MG
Price: $727.65
Updated: 2021/12/16

ChemScene

Product number: CS-0007735
Product name: CAY10471Racemate
Purity: 99.35%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

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(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Chemical Properties,Usage,Production

Biological Activity

TM30089 is a ramatroban analog and an orally active, high-affinity, potent and selective prostaglandin D2 receptor 2 (DP2; CRTH2) antagonist (Ki = 0.6 nM/hDP2 against 1.2 nM PGD2; Ki = 1.2 μM/hDP1 against 0.5 nM PGD2, >10 μM/hTP against 5 nM SQ29548) th at blocks PGD2-induced responses in hDP2 transfectants (IP1/βarr IC50 = 1.2/3.0 nM) and exhibits in vivo efficacy in a murine model of renal tubulointerstitial fibrosis (20 mg/kg b.i.d. p.o., starting 4 days before or 3 days after unilateral ureteral obstruction/UUO).

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Suppliers

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844639-57-2, (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACIDRelated Search:

TPP 4'-Hydroxyacetophenone 2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)BORANE Aniline

TM30089

9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]MethylaMino]-1,2,3,4-tetrahydro-

CS-1157

TM30089 (CAY10471)

TM 30089;TM-30089

CAY10471 Racemate

TM30089 Racemate

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

CAY 10471,CAY10471,TM30089,Inhibitor,CAY-10471,TM 30089,TM-30089,CAY10471 Racemate,inhibit,Prostaglandin Receptor,CAY-10471 Racemate

CAY10471 Racemate, 10 mM in DMSO

844639-57-2