4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE
- Product Name
- 4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE
- CAS No.
- 34334-28-6
- Chemical Name
- 4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE
- Synonyms
- AKOS B030325;4-(4-METHYLPIPERAZINO)BENZONITRILE;4-(Methyl-piperazin-1-yl)benzonitrile;4-(4-Methyl-1-piperazinyl)benzonitrile;4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE;Benzonitrile, 4-(4-methyl-1-piperazinyl)-
- CBNumber
- CB0244992
- Molecular Formula
- C12H15N3
- Formula Weight
- 201.27
- MOL File
- 34334-28-6.mol
4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE Property
- Melting point:
- 104-105℃
- Boiling point:
- 356.5±37.0 °C(Predicted)
- Density
- 1.14
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.62±0.42(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-B1832
- Product name
- Benzonitrile,4-(4-methyl-1-piperazinyl)-
- Packaging
- 5g
- Price
- $113
- Updated
- 2021/12/16
- Product number
- 4116AB
- Product name
- 4-(4-Methylpiperazin-1-yl)benzonitrile
- Packaging
- 10g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 4116AB
- Product name
- 4-(4-Methylpiperazin-1-yl)benzonitrile
- Packaging
- 5g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- CS-B1832
- Product name
- Benzonitrile,4-(4-methyl-1-piperazinyl)-
- Packaging
- 10g
- Price
- $187
- Updated
- 2021/12/16
- Product number
- CS-B1832
- Product name
- Benzonitrile,4-(4-methyl-1-piperazinyl)-
- Packaging
- 25g
- Price
- $374
- Updated
- 2021/12/16
4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE Chemical Properties,Usage,Production
Synthesis
109-01-3
1194-02-1
34334-28-6
The general procedure for the synthesis of 4-(4-methylpiperazin-1-yl)benzonitrile from N-methylpiperazine and p-fluorobenzonitrile was as follows: to a solution of dimethyl sulfoxide (7 mL) containing 4-fluorobenzonitrile (1.0 g, 8.25 mmol) and potassium carbonate (2.27 g, 16.51 mmol) was added 1-methylpiperazine (1.36 mL, 12.38 mmol). The reaction mixture was stirred at room temperature for the reaction. Upon completion of the reaction, the target product 4-(4-methylpiperazin-1-yl)benzonitrile (1.54 g, 93% yield) was obtained by conventional post-processing. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3) and ESI-MS: 1H-NMR δ 2.36 (3H, s), 2.55 (4H, t, J = 4.88 Hz), 3.35 (4H, t, J = 4.88 Hz), 6.87 (2H, d, J = 8.78 Hz), 7.49 (2H, d, J = 8.78 Hz); ESI-MS m/z 202.1 ([M+H]+).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[2] Patent: WO2005/7625, 2005, A2. Location in patent: Page 63
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2008, vol. 183, # 5, p. 1252 - 1263
[4] Patent: WO2016/96709, 2016, A1. Location in patent: Page/Page column 50
[5] Patent: US2008/146542, 2008, A1. Location in patent: Page/Page column 36
4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE Preparation Products And Raw materials
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View Lastest Price from 4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE manufacturers
- Product
- 4-(4-METHYL-PIPERAZIN-1-YL)BENZONITRILE 34334-28-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Judy@coreychem.com
- Release date
- 2019-12-18