N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE

Product Name: N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
CAS No.: 189060-98-8
Chemical Name: N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
Synonyms: N B2904;Ngb-2904;Ngb 2904;NGB2904 HCl;NGB 2904 HYDROCHLORIDE;NGB 2904, 10 mM in DMSO;N-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-3-fluorenylcarboxamide;N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide;N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide;9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-
CBNumber: CB02453431
Molecular Formula: C28H29Cl2N3O
Formula Weight: 494.46
MOL File: 189060-98-8.mol

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N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Property

Boiling point:: 691.0±55.0 °C(Predicted)
Density: 1.264±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: 25 mM,Ethanol: 5 mM
pka: 14.70±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2635
Product name: NGB2904
Purity: ≥98%(HPLC)
Packaging: 10
Price: $217
Updated: 2021/12/16

Tocris

Product number: 2635
Product name: NGB2904
Purity: ≥98%(HPLC)
Packaging: 50
Price: $872
Updated: 2021/12/16

TRC

Product number: N393505
Product name: NGB2904
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 255979
Product name: NGB 2904
Packaging: 10mg
Price: $466
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0360490
Product name: N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $501.96
Updated: 2021/12/16

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N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

NGB 2904 is a highly-selective D3DR antagonist.

Biological Activity

Potent and selective dopamine D 3 receptor antagonist (K i values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D 3 , D 2 , 5-HT 2 , α 1 , D 4 , D 1 and D 5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC 50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

in vivo

NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice^[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice^[3].

IC 50

D₃ Receptor: 1.4 nM (Ki)

N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Suppliers

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189060-98-8, N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDERelated Search:

2-FLUORENECARBOXALDEHYDE 1-(2,3-Dichlorophenyl)piperazine hydrochloride N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE

9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-

N-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-3-fluorenylcarboxamide

Ngb 2904

Ngb-2904

N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide

N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE

NGB 2904 HYDROCHLORIDE

N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide

NGB2904 HCl

addiction,NGB 2904,orally,active,cocaine,Dopamine Receptor,dopamine,inhibit,Inhibitor,selective

N B2904

NGB 2904, 10 mM in DMSO

189060-98-8

189060-98-3

C28H30Cl3N3O

C28H29Cl2N3OHCl

C28H29Cl2N3O