ChemicalBook > CAS DataBase List > TCS 46B
TCS 46B
- Product Name
- TCS 46B
- CAS No.
- 302799-86-6
- Chemical Name
- TCS 46B
- Synonyms
- TCS 46B;1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one;5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1H-benzo[d]imidazol-2(3H)-one;5-(3-(4-Benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one;2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-
- CBNumber
- CB02453446
- Molecular Formula
- C22H23N3O
- Formula Weight
- 345.44
- MOL File
- 302799-86-6.mol
More
Less
TCS 46B Property
- Boiling point:
- 440.4±38.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
- pka
- 11.51±0.30(Predicted)
- color
- Off-white to light yellow
More
Less
N-Bromosuccinimide Price
Tocris
- Product number
- 2782
- Product name
- TCS46b
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $179
- Updated
- 2021/12/16
Tocris
- Product number
- 2782
- Product name
- TCS46b
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $662
- Updated
- 2021/12/16
TRC
- Product number
- T012625
- Product name
- TCS46b
- Packaging
- 25mg
- Price
- $265
- Updated
- 2021/12/16
Usbiological
- Product number
- 466895
- Product name
- TCS 46b
- Packaging
- 10mg
- Price
- $418
- Updated
- 2021/12/16
Usbiological
- Product number
- 256882
- Product name
- TCS 46b
- Packaging
- 10mg
- Price
- $432
- Updated
- 2021/12/16
More
Less
TCS 46B Chemical Properties,Usage,Production
Uses
TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist.
Biological Activity
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.
in vivo
TCS 46b (Compound 46b; 10 and 30 mg/kg; p.o. or i.p.; once) potentiates the effects of L-DOPA in the 6-OHDA-lesioned rat[1].
| Animal Model: | Sprague?Dawley rats, 6-hydroxydopamine-lesioned (6-OHDA) rat model[1] |
| Dosage: | 10 and 30 mg/kg |
| Administration: | PO or IP, once |
| Result: | Showed significant potentiation of the effects of L-DOPA in this model. |
TCS 46B Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
TCS 46B Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8447
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- 17625585511
- Fax
- qq：1580084073
- 1580084073@qq.com
- Country
- China
- ProdList
- 960
- Advantage
- 58