TCS 46B

Product Name: TCS 46B
CAS No.: 302799-86-6
Chemical Name: TCS 46B
Synonyms: TCS 46B;1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one;5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1H-benzo[d]imidazol-2(3H)-one;5-(3-(4-Benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one;2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-
CBNumber: CB02453446
Molecular Formula: C22H23N3O
Formula Weight: 345.44
MOL File: 302799-86-6.mol

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TCS 46B Property

Boiling point:: 440.4±38.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
form: Powder
pka: 11.51±0.30(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 2782
Product name: TCS46b
Purity: ≥98%(HPLC)
Packaging: 10
Price: $179
Updated: 2021/12/16

Tocris

Product number: 2782
Product name: TCS46b
Purity: ≥98%(HPLC)
Packaging: 50
Price: $662
Updated: 2021/12/16

TRC

Product number: T012625
Product name: TCS46b
Packaging: 25mg
Price: $265
Updated: 2021/12/16

Usbiological

Product number: 466895
Product name: TCS 46b
Packaging: 10mg
Price: $418
Updated: 2021/12/16

Usbiological

Product number: 256882
Product name: TCS 46b
Packaging: 10mg
Price: $432
Updated: 2021/12/16

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TCS 46B Chemical Properties,Usage,Production

Uses

TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist.

Biological Activity

Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.

in vivo

TCS 46b (Compound 46b; 10 and 30 mg/kg; p.o. or i.p.; once) potentiates the effects of L-DOPA in the 6-OHDA-lesioned rat^[1].

Animal Model:	SpragueDawley rats, 6-hydroxydopamine-lesioned (6-OHDA) rat model^[1]
Dosage:	10 and 30 mg/kg
Administration:	PO or IP, once
Result:	Showed significant potentiation of the effects of L-DOPA in this model.

TCS 46B Preparation Products And Raw materials

Raw materials

Preparation Products

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TCS 46B Suppliers

China 37 United Kingdom 1 United States 5 USA 1 Global 44

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4810
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71615
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7998
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9023
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32469
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 997
Advantage: 58

302799-86-6, TCS 46BRelated Search:

N-BUTYL-3-PHENYLPROP-2-YN-1-AMINE TCS 46B

TCS 46B

1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one

2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-

5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1H-benzo[d]imidazol-2(3H)-one

5-(3-(4-Benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

302799-86-6