ChemicalBook > CAS DataBase List > 4-AMINO-6-MORPHOLINOPYRIMIDINE

4-AMINO-6-MORPHOLINOPYRIMIDINE

Product Name
4-AMINO-6-MORPHOLINOPYRIMIDINE
CAS No.
96225-80-8
Chemical Name
4-AMINO-6-MORPHOLINOPYRIMIDINE
Synonyms
6-MorpholinopyriMidin-4-aMine;4-AMINO-6-MORPHOLINOPYRIMIDINE;6-morpholino-pyrimidin-4-ylamine;6-morpholin-4-ylpyrimidin-4-amine;6-(4-morpholinyl)-4-Pyrimidinamine;4-Pyrimidinamine, 6-(4-morpholinyl)-;4-AMINO-6-MORPHOLINOPYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB02453774
Molecular Formula
C8H12N4O
Formula Weight
180.21
MOL File
96225-80-8.mol
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4-AMINO-6-MORPHOLINOPYRIMIDINE Property

storage temp. 
2-8°C(protect from light)
Appearance
Light yellow to yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B497323
Product name
6-Morpholinopyrimidin-4-amine
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA153601
Product name
4-Amino-6-morpholinopyrimidine
Packaging
500mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA153601
Product name
4-Amino-6-morpholinopyrimidine
Packaging
1g
Price
$137.5
Updated
2021/12/16
AK Scientific
Product number
W9805
Product name
4-Amino-6-morpholinopyrimidine
Packaging
1g
Price
$171
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA153601
Product name
4-Amino-6-morpholinopyrimidine
Packaging
2g
Price
$235
Updated
2021/12/16
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4-AMINO-6-MORPHOLINOPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

110-91-8

5305-59-9

96225-80-8

General procedure for the synthesis of 6-N-morpholinopyrimidin-4-amine from 4-amino-6-chloropyrimidine and morpholine: 400 mg of 4-amino-6-chloropyrimidine and 1.51 g (1.5 eq.) of cesium carbonate were added to a reaction flask, 10 mL of N,N-dimethylformamide (DMF) was added as solvent followed by 405 μL (1.5 eq.) of morpholine. The reaction mixture was heated to 100 °C and stirred for 12 hours. After completion of the reaction, an appropriate amount of water was added and the organic phase was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and the solvent was evaporated under reduced pressure. The residue was separated and purified by silica gel column chromatography using methanol/dichloromethane (1:50, v/v) as eluent, resulting in 245 mg of yellow solid product in 44% yield.

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 18, p. 8326 - 8344
[2] Patent: CN105418592, 2016, A. Location in patent: Paragraph 0097; 0098; 0099; 0100; 0101
[3] Journal of the American Chemical Society, 1958, vol. 80, p. 2182,2184
[4] Patent: US4503050, 1985, A

4-AMINO-6-MORPHOLINOPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-6-MORPHOLINOPYRIMIDINE Suppliers

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View Lastest Price from 4-AMINO-6-MORPHOLINOPYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
4-AMINO-6-MORPHOLINOPYRIMIDINE 96225-80-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-13

96225-80-8, 4-AMINO-6-MORPHOLINOPYRIMIDINERelated Search:

Diphenhydramine Morpholinazole Pyrimidine 4-(6-MORPHOLINO-2-PHENYL-4-PYRIMIDINYL)MORPHOLINE 4-AMINO-6-MORPHOLINOPYRIMIDINE 4,6-DIMORPHOLINO-2-PYRIMIDINYL METHYL SULFIDE BUTTPARK 126\40-04 APILIMOD N-ETHYL-2-(METHYLSULFANYL)-6-MORPHOLINO-4-PYRIMIDINAMINE 4-(6-Amino-2-chloro-5-nitro-4-pyrimidinyl)morpholine 4-[2-PHENYL-6-(1-PYRROLIDINYL)-4-PYRIMIDINYL]MORPHOLINE

  • 4-AMINO-6-MORPHOLINOPYRIMIDINE
  • 6-(4-morpholinyl)-4-Pyrimidinamine
  • 6-morpholin-4-ylpyrimidin-4-amine
  • 6-morpholino-pyrimidin-4-ylamine
  • 6-MorpholinopyriMidin-4-aMine
  • 4-Pyrimidinamine, 6-(4-morpholinyl)-
  • 4-AMINO-6-MORPHOLINOPYRIMIDINE ISO 9001：2015 REACH
  • 96225-80-8
  • Heterocycle-Pyrimidine series