APILIMOD

Product Name: APILIMOD
CAS No.: 541550-19-0
Chemical Name: APILIMOD
Synonyms: Sta5326;Sta-5326;Sta 5326;APILIMOD;APILIMODUM;Apilimod, >98%;ApiliMod(STA5326);STA 5326; STA5326; STA-5326;Benzaldehyde,3-methyl-,2-[6-(4-morpholinyl)-2-[2-(2-pyridiny...;1H-Benzimidazole-1-carboxylicacid,2,3-dihydro-6-oxo-,ethylester
CBNumber: CB61091430
Molecular Formula: C23H26N6O2
Formula Weight: 418.49
MOL File: 541550-19-0.mol

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APILIMOD Property

Boiling point:: 655.1±65.0 °C(Predicted)
Density: 1.24
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
pka: 12.56±0.10(Predicted)
form: solid
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-2341
Product name: Apilimod
Purity: 99.61%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-2341
Product name: Apilimod
Purity: 99.61%
Packaging: 10mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-2341
Product name: Apilimod
Purity: 99.61%
Packaging: 50mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: SYN5487
Product name: Apilimod
Packaging: 10mg
Price: $156.92
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004744
Product name: 4'-ACETYL-BIPHENYL-4-CARBOXYLIC ACID (4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYL)-AMIDE
Purity: 95.00%
Packaging: 5MG
Price: $288.2
Updated: 2021/12/16

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APILIMOD Chemical Properties,Usage,Production

Description

Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level.? Suppresses Th1 but not Th2 immune response.1? Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells.? Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2? It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3? Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4

Chemical Properties

Off-White Solid

Uses

Apilimod is a small-molecule that selectively suppresses synthesis of IL-12 and IL-23. Apilimod reduces dendritic cell infiltration in psoriasis.

References

Wada et al. (2007), Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL23 inhibitor; Blood 109 1156 Cai et al. (2013), PIKfyve, a class III PI-kinase, is the target of the small molecule IL12/23 inhibitor apilimod and a new player in toll-like receptor signaling; Chem. Biol., 20 912 Gayle et al. (2016), Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma; Blood, 129 1768 Kang et al. (2020), Inhibition of PIKfyve kinase prevents infection by Zaire ebola virus and SARS-CoV-2; Proc. Natl. Acad. Sci. USA 117 20803

APILIMOD Preparation Products And Raw materials

Raw materials

Preparation Products

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APILIMOD Suppliers

Canada 1 China 95 China Hong Kong 1 India 2 United States 10 Global 109

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973 13515979683
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1075
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1813
Advantage: 55

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View Lastest Price from APILIMOD manufacturers

Career Henan Chemical Co

Product: APILIMOD 541550-19-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

541550-19-0, APILIMODRelated Search:

Volasertib (BI 6727) Aprepitant Biapenem Pidotimod Semapimod Iguratimod CIVENTICHEM CV-4057 BAF-312(SiponiMod) tasquinimod Tiprotimod Ozanimod Fingolimod hydrochloride Tapinarof NOTUMib-1 4,6-Diamino-2-pyrimidinol 2-HYDROXY-4-HYDRAZINO-PYRIMIDINE 4-AMINO-6-MORPHOLINOPYRIMIDINE APILIMOD

APILIMOD

APILIMODUM

(E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

Sta 5326

Sta5326

Sta-5326

ApiliMod(STA5326)

3-Methylbenzaldehyde 2-[6-(4-Morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4- pyriMidinyl]hydrazone

3-Methylbenzaldehyde [6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone

Benzaldehyde,3-methyl-,2-[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone

4-{6-[(2E)-2-(3-Methylbenzylidene)hydrazino]-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl}morpholine

4-{6-[(E)-2-[(3-methylphenyl)methylidene]hydrazin-1-yl]-2-[2-(pyridin-2-yl)ethoxy]pyrimidin-4-yl}morpholine

N-[(e)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine

STA 5326; STA5326; STA-5326

Apilimod, >98%

4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

Benzaldehyde,3-methyl-,2-[6-(4-morpholinyl)-2-[2-(2-pyridiny...

1H-Benzimidazole-1-carboxylicacid,2,3-dihydro-6-oxo-,ethylester

541550-19-0

Inhibitors

API

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals