CIVENTICHEM CV-4057

Product Name: CIVENTICHEM CV-4057
CAS No.: 248281-84-7
Chemical Name: CIVENTICHEM CV-4057
Synonyms: LAQ;CS-82;ABR 215062;ABR-215062;Lanquinimod;CIVENTICHEM;oro-N-ethyL;-2-oxo-N-phenyL;Laquinimod, >=98%;ine-3-carboxamide
CBNumber: CB7836628
Molecular Formula: C19H17ClN2O3
Formula Weight: 356.8
MOL File: 248281-84-7.mol

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CIVENTICHEM CV-4057 Property

Melting point:: 201 °C (decomp)
Boiling point:: 484.8±45.0 °C(Predicted)
Density: 1.395±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 4.50±1.00(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2504
Product name: Laquinimod
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $40.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2504
Product name: Laquinimod
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $386
Updated: 2024/03/01

Sigma-Aldrich

Product number: CVT00095
Product name: 5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide
Packaging: 1g
Price: $724
Updated: 2024/03/01

Cayman Chemical

Product number: 24187
Product name: Laquinimod
Purity: ≥98%
Packaging: 100mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 24187
Product name: Laquinimod
Purity: ≥98%
Packaging: 250mg
Price: $172
Updated: 2024/03/01

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CIVENTICHEM CV-4057 Chemical Properties,Usage,Production

Description

Laquinimod (248281-84-7) is an immunomodulator1 that inhibits inflammation2 and autoimmunity3,4 via activation of the aryl hydrocarbon receptor (AhR)5. It has been investigated as a treatment for multiple sclerosis6 and has shown efficacy in Huntington’s disease models7,8.

Definition

ChEBI: Laquinimod is an aromatic amide.

in vitro

abr-215062 was shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (eae) [1].

in vivo

abr-215062 dose-dependently inhibited disease and showed better disease inhibitory effects as compared to roquinimex (linomide). furthermore, abr-215062 inhibited the inflammation of both cd4+ t cells and macrophages into central nervous tissues [2].

References

J?nsson et al. (2004), Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure-Activity Relationship; Med. Chem. 47 2075 Rothhammer et al. (2021); Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS, Neurol. Neuroimmunol. Neuroinflamm., 8 e946 Pitarokoili et al. (2014), Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis; Neuroimmunol., 274 38 Ott et al. (2019), Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity; Neuroinflammation, 16 49 Kaye et al. (2016), Laquinimod arrests experimental autoimmune encephalitis by activating the aryl hydrocarbon receptor; Natl. Acad. Sci. USA., 113 E6145 Th?ne and Linker (2016), Laquinimod in the treatment of multiple sclerosis: a review of the data so far; Drug Des. Devel. Ther., 10 1111 Dobson et al. (2016), Laquinimod dampens hyperactive cytokine production in Huntington’s disease patient myeloid cells; Neurochem., 137 782 Garcia-Miralles et al. (2016), Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease; Rep., 6 31652

CIVENTICHEM CV-4057 Preparation Products And Raw materials

Raw materials

Preparation Products

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CIVENTICHEM CV-4057 Suppliers

China 108 India 1 United Kingdom 1 United States 17 Global 127

Shanghai Boyle Chemical Co., Ltd.

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248281-84-7, CIVENTICHEM CV-4057Related Search:

Tacrolimus WY-14643 Astemizole BESTATIN HYDROCHLORIDE Pidotimod Semapimod Iguratimod BAF-312(SiponiMod) tasquinimod Tiprotimod APILIMOD Ozanimod Fingolimod hydrochloride Tapinarof Glatiramer acetate Roquinimex CIVENTICHEM CV-4057 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID

CIVENTICHEM CV-4057

LAQUINIMOD,5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL-PHENYL-AMIDE

ABR-215062 (Laquinimod)

CIVENTICHEM

CS-82

ABR215062; ABR 215062 (LAQUINIMOD)

5-Chloro-4-hydroxy-1-Methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl-phenyl-aMide

LaquiniMod, SAIK-MS coMpound, ABR-215062

5-Chloro-4-hydroxy-1-methyl-2-oxo-N-ethyl-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Lanquinimod

LaquiniMod,CiventicheMCV-4057,5-Chloro-4-hydroxy-1-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylicacidethylphenylaMide

5-chloro-N-ethyl-4-hydroxy-1-Methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxaMide

ABR 215062

ABR-215062

LaquiniMod (ABR-215062)

LAQ

Laquinimod potassium salt

5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide

Laquinimod, >=98%

5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide

-1,2-dihydroquinoL

-2-oxo-N-phenyL

-4-hydroxy-1-methyL

ine-3-carboxamide

oro-N-ethyL

3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-

5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihyd...

inhibit,multiple sclerosis,relapsing remitting,carboxamide,Nuclear factor-kappaB,Apoptosis,Inhibitor,ABR 215062,Nuclear factor-κB,immunomodulator,ABR215062,chronic progressive,neurodegenerative disease,inflammation,NF-κB,Laquinimod,Orally,neurodegeneration

248281-84-7

Inhibitors

api

Heterocycles