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BESTATIN HYDROCHLORIDE

Product Name
BESTATIN HYDROCHLORIDE
CAS No.
65391-42-6
Chemical Name
BESTATIN HYDROCHLORIDE
Synonyms
BESTATIN HCL;Bestatin.HCI;Ubenimex HCl;Ubenimex-d7 HCl;BESTATIN HYDROCHLORIDE;Ubenimex hydrochloride;HYDROCHLORIDE,Ubenimex;Bestatin research grade;BESTATIN HYDROCHLORIDE USP/EP/BP;Bestatin-d7 HCl (Ubenimex-d7 HCl)
CBNumber
CB2172341
Molecular Formula
C16H25ClN2O4
Formula Weight
344.83
MOL File
65391-42-6.mol
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BESTATIN HYDROCHLORIDE Property

Melting point:
216-218 °C
storage temp. 
2-8°C
solubility 
H2O: 25 mg/mL, clear, colorless
form 
White to off-white powder.
color 
White
Water Solubility 
Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN 
4628066
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChIKey
XGDFITZJGKUSDK-UDYGKFQRSA-N
CAS DataBase Reference
65391-42-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
F 
3-10
HS Code 
29242995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8385
Product name
Bestatin hydrochloride
Purity
≥98% (HPLC)
Packaging
1mg
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
B8385
Product name
Bestatin hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$164
Updated
2024/03/01
Sigma-Aldrich
Product number
10874515001
Product name
Bestatin
Purity
[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucinehydrochloride
Packaging
10mg
Price
$244
Updated
2022/05/15
TCI Chemical
Product number
B4000
Product name
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$194
Updated
2024/03/01
Alfa Aesar
Product number
J60384
Product name
Bestatin hydrochloride, 98%
Packaging
5mg
Price
$87.65
Updated
2024/03/01
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BESTATIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Uses

Bestatin Hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase. It is the salt form of Bestatin (B319500).

Uses

competitive aminopeptidase B inhibitor

Uses

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Uses

Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.

Definition

ChEBI: Bestatin (hydrochloride) is a peptide.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

in vivo

in a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) showed a significant inhibitory activity against the melanoma cell-induced angiogenesis. bestatin also inhibited the tube-like formation of human umbilical vein endothelial cells (huvecs). furthermore, after the orthotopic implantation of b16-bl6 melanoma cells into mice, bestatin administration (50-100 mg/kg/day, i.p) reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice [1].

References

1) Orning et al. (1991), Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes; J. Biol. Chem., 266 1375 2) Wang et al. (2010), The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor; Biol. Pharm. Bull., 33 1658

BESTATIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BESTATIN HYDROCHLORIDE Suppliers

Americas 1 China 98 Europe 4 France 1 Germany 5 India 7 Japan 2 Switzerland 3 United Kingdom 9 United States 31 Global 161
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
967
Advantage
59
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
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57
AF Biochem Co., Ltd.
Tel
+86-028-60911900 13540204019
Email
sales@afbiochem.com
Country
China
ProdList
481
Advantage
57
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
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75
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View Lastest Price from BESTATIN HYDROCHLORIDE manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
BESTATIN HYDROCHLORIDE 65391-42-6
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Bestatin hydrochloride 65391-42-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Bestatin hydrochloride 65391-42-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

65391-42-6, BESTATIN HYDROCHLORIDERelated Search:

CARBOXYPEPTIDASE A CARBOXYPEPTIDASE B CARBOXYPEPTIDASE B Trypsin Chymotrypsin N-CARBOBENZOXY-DL-LEUCINE 1,3-Diamino-2-propanol Bestatin N-(2-HYDROXYETHYL)LACTAMIDE BESTATIN HYDROCHLORIDE (R)-(-)-4-PHENYL-2-BUTANOL D(+)-Phenylalaninol H-BETA-ALA-NH2 HCL 1,3-Dimethylbutylamine L-Leucine hydrochloride DIETHANOLAMINE HYDROCHLORIDE Betaine hydrochloride N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

  • N-[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE HYDROCHLORIDE
  • N-(3R-AMINO-2S-HYDROXY-1-OXO-4-PHENYLBUTYL)-L-LEUCINE, MONOHYDROCHLORIDE
  • [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HCL
  • [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HYDROCHLORIDE
  • (AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE HYDROCHLORIDE
  • BESTATIN HCL
  • BESTATIN HYDROCHLORIDE
  • N-(2S,3R-3-AMINO-2-HYDROXY-4-PHENYLBUTY- RYL)-L-LEUCINE HCL
  • Bestatin.HCI
  • N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine monohydrochloride
  • (S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid hydrochloride
  • L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-, hydrochloride (1:1)
  • Ubenimex Hydrochloride [for Biochemical Research]
  • Ubenimex hydrochloride
  • Bestatin research grade
  • Bestatin-d7 HCl (Ubenimex-d7 HCl)
  • Ubenimex-d7 HCl
  • HYDROCHLORIDE,Ubenimex
  • Bestatin hydrochloride, ≥98% (HPLC)
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride &gt
  • BESTATIN HYDROCHLORIDE USP/EP/BP
  • Ubenimex-d7 HClQ: What is Ubenimex-d7 HCl Q: What is the CAS Number of Ubenimex-d7 HCl
  • (4S,5R)-5-amino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenyl-D-norleucine hydrochloride
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride
  • (S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid hydrochloride[Ubenimex Hydrochloride
  • Ubenimex HCl，Bestatin hydrochloride
  • Ubenimex HCl
  • 65391-42-6
  • C16H24N2O4ClH
  • C16HH24N2O4xHCL
  • Antibiotics A-F
  • Antibiotics A to Z
  • Antibiotics
  • BioChemical
  • peptides
  • Bestatin
  • inhibitor
  • Pepetides