1,3-Diamino-2-propanol
- Product Name
- 1,3-Diamino-2-propanol
- CAS No.
- 616-29-5
- Chemical Name
- 1,3-Diamino-2-propanol
- Synonyms
- 1,3-DIAMINOPROPAN-2-OL;1,3-DIAMINO-2-HYDROXYPROPANE;Glycerol-α,γ-diamine;1,3-diamino-2-propano;1,3-DIAMINO-2-PROPANOL;2-Propanol, 1,3-diamino-;2-Hydroxypropylenediamine;1,3-Diamino-2-propanol>1,3-DIAMINO-2-HYDROXYPROPAN;1,3-Diamino-2-propanol ,97%
- CBNumber
- CB9315639
- Molecular Formula
- C3H10N2O
- Formula Weight
- 90.12
- MOL File
- 616-29-5.mol
1,3-Diamino-2-propanol Property
- Melting point:
- 40-44 °C(lit.)
- Boiling point:
- 235°C
- Density
- 1.0352 (rough estimate)
- refractive index
- 1.4610 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- water: soluble1g/10 mL
- form
- Low Melting Solid
- pka
- 9.69, 7.93(at 20℃)
- color
- White to yellow
- Water Solubility
- Very soluble in water.
- BRN
- 741859
- CAS DataBase Reference
- 616-29-5(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Propanol, 1,3-diamino- (616-29-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- RIDADR
- 3259
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29221990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 33262
- Product name
- 1,3-Diamino-2-propanol
- Purity
- purum, ≥96.5% (GC)
- Packaging
- 5G
- Price
- $60.6
- Updated
- 2024/03/01
- Product number
- 33262
- Product name
- 1,3-Diamino-2-propanol
- Purity
- purum, ≥96.5% (GC)
- Packaging
- 25g
- Price
- $219
- Updated
- 2024/03/01
- Product number
- H0497
- Product name
- 1,3-Diamino-2-propanol
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- H0497
- Product name
- 1,3-Diamino-2-propanol
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $109
- Updated
- 2024/03/01
- Product number
- A19618
- Product name
- 1,3-Diamino-2-propanol, 97%
- Packaging
- 10g
- Price
- $57.65
- Updated
- 2024/03/01
1,3-Diamino-2-propanol Chemical Properties,Usage,Production
Description
1,3-Diamino-2-propanol (DAP), also known as 2-hydroxy-1,3-diaminopropane, is a white to yellowish low melting solid. Keep in a cool, well-ventilated place. Avoid prolonged storage periods. Store under inert gas, in a tightly sealed container and at ambient temperatures. 1,3-Diamino-2-propanol is incompatible with acids and strong oxidizing agents and should not be stored or handled in their vicinity.
Chemical Properties
white to yellowish low melting solid
Uses
- 1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.
- It is a precursor to synthesize the fluorogenic dsDNA binder, N1,N3-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).
- It can also be used as a branching unit in the synthesis of peptide dendrimers.
Application
1,3-diamino-2-propanol (DAPL), a close analog of 1,3-diaminopropane, is an indirect inhibitor of ornithine decarboxylase (ODC). It is administered orally and inhibits ODC activity in the livers of partially hepatectomized rats[1]. It contains amine and hydroxyl groups. Therefore, it can be crosslinked with the carboxyl group via covalent and hydrogen bonds and has been investigated as a diamine monomer in the aqueous phase to fabricate the high-performance RO membrane[2].
Preparation
1,3-Diamino-2-propanol is synthesized by reacting Epichlorohydrin with ammonia in alkaline
environment by adding sodium hydroxide. Afterwards, the product
undergoes a series of purification steps.
Hazard
1,3-Diamino-2-propanoli is a hazardous chemical.
H302 (66.17%): Harmful if swallowed [Warning Acute toxicity, oral]. H314 (66.92%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]. H315 (33.08%): Causes skin irritation [Warning Skin corrosion/irritation]. H317 (66.17%): May cause an allergic skin reaction [Warning Sensitization, Skin]. H318 (66.17%): Causes serious eye damage [Danger Serious eye damage/eye irritation]. H319 (33.08%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]. H335 (34.59%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation.
Purification Methods
Dissolve it in an equal amount of water, shake it with charcoal and distil it at 68o/0.1mm. The distillate solidifies. It is too viscous to be distilled through a packed column. [Beilstein 4 IV 1694.]
References
[1] Raunio H, et al. The inhibition of induction of microsomal monooxygenase activity by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase. Biochemical and Biophysical Research Communications, 1979; 9: 285–290.
[2] Su T, et al. A novel polyamide thin-film nanocomposite reverse osmosis membrane constructed by a 3D multi-layer graphene oxide assembled with 1,3-diamino-2-propanol. Journal of Membrane Science, 2023; 681: 121773.
1,3-Diamino-2-propanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-Diamino-2-propanol manufacturers
- Product
- 1,3-Diaminopropan-2-ol 616-29-5
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22
- Product
- 1,3-Diamino-2-propanol 616-29-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-13
- Product
- 1,3-Diamino-2-propanol 616-29-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-03-08