Chymotrypsin
- Product Name
- Chymotrypsin
- CAS No.
- 9004-07-3
- Chemical Name
- Chymotrypsin
- Synonyms
- α-Chymotrypsin;A-CHYMOTRYPSIN;EC 3.4.21.1;ALPHA-CHYMOTRYPSIN;zolyse;zolyes;D03484;chymar;ec3445;ec3446
- CBNumber
- CB4167554
- Molecular Formula
- N/A
- Formula Weight
- 0
- MOL File
- Mol file
Chymotrypsin Property
- Melting point:
- 127°C
- Density
- 1.37[at 20℃]
- vapor pressure
- 0Pa at 25℃
- storage temp.
- -20°C
- solubility
- Reconstitute in 1mM HCl. Soluble at 10mg/ml in 1mM HCl. 2mM calcium chloride serves as a stabilizer. Store aliquoted solutions at -20°C for up to a week.
- form
- salt-free, lyophilized powder
- color
- white
- Water Solubility
- 125g/L at 25℃
- Merck
- 13,2282
- LogP
- -1.3 at 20℃
- EPA Substance Registry System
- Chymotrypsin (9004-07-3)
Safety
- Hazard Codes
- Xn,B
- Risk Statements
- 36/37/38-42/43-42
- Safety Statements
- 26-36-36/37-24-22
- WGK Germany
- 3
- RTECS
- GC3050000
- F
- 3-10
- TSCA
- Yes
- HS Code
- 35079090
- Hazardous Substances Data
- 9004-07-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SRP6509
- Product name
- Chymotrypsin from human pancreas
- Purity
- ≥95% (SDS-PAGE)
- Packaging
- 100μg
- Price
- $428
- Updated
- 2024/03/01
- Product number
- CHY5S
- Product name
- α-Chymotrypsin from bovine pancreas
- Purity
- ≥40?units/mgprotein,vialof5?mg
- Packaging
- 10vials
- Price
- $310
- Updated
- 2024/03/01
- Product number
- C9134
- Product name
- α-Chymotrypsin−Agarose from bovine pancreas
- Purity
- lyophilized powder, 2,000-3,500?units/g agarose (One ml gel will yield 65-120?units)
- Packaging
- 50units
- Price
- $327
- Updated
- 2024/03/01
- Product number
- C9134
- Product name
- α-Chymotrypsin−Agarose from bovine pancreas
- Purity
- lyophilized powder, 2,000-3,500?units/g agarose (One ml gel will yield 65-120?units)
- Packaging
- 100units
- Price
- $582
- Updated
- 2024/03/01
- Product number
- C8946
- Product name
- α-Chymotrypsin from human pancreas
- Purity
- lyophilized powder
- Packaging
- 1VIAL
- Price
- $688
- Updated
- 2024/03/01
Chymotrypsin Chemical Properties,Usage,Production
Chemical Properties
Lyophilized powder, dialyzed
Uses
α-Chymotrypsin from bovine has been used in a study to inform proteasome inhibition in order to advance anticancer research. α-Chymotrypsin from bovine has also been used in a study that functionalized surface anchored poly(methylhydrosiloxane) thin films on oxidized silicon wafers.
Uses
The enzyme from Sigma has been used to assess the effect of limited proteolysis with α-chymotrypsin on the sperm penetration.
Uses
α-Chymotrypsin from bovine pancreas has been used in a study to investigate protein extraction by Winsor-III microemulsion systems. α-Chymotrypsin from bovine pancreas has also been used in a study to investigate a new specific fullerene-based fluorescent probe for trypsin.
General Description
Chymotrypsin (Chymar) is extractedfrom mammalian pancreas and is used in cataractsurgery. A dilute solution is used to irrigate the posteriorchamber of the eye to dissolve the fine filaments that holdthe lens.
Biochem/physiol Actions
α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. Molecular weight of this enzyme is found to be 25 kDa. Its pI is 8.75. It selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan, and leucine. Ca2+ activates and stabilizes the enzyme. The enzyme is inhibited by diisopropyl fluorophosphate (DFP), phenylmethanesulfonyl fluoride (PMSF), N-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK), chymostatin, aprotinin, α1-antitrypsin, α2-macroglobulin, 10 mM Cu2+ and Hg2+.
Purification Methods
α-Chymotrypsin is crystallised twice from four-tenths saturated ammonium sulfate solution, then dissolved in 1mM HCl and dialysed against 1mM HCl at 2-4o. The solution is stored at 2o [Lang et al. J Am Chem Soc 80 4923 1958].
Chymotrypsin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Chymotrypsin manufacturers
- Product
- Chymotrypsin 9004-07-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.0%
- Supply Ability
- 1kg/month
- Release date
- 2021-08-26
- Product
- Chymotrypsin 9004-07-3
- Price
- US $78.00-65.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-08-20
- Product
- Chymotrypsin 9004-07-3
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99.9%
- Supply Ability
- 8000kgs/month
- Release date
- 2021-03-15