Aprotinin
- Product Name
- Aprotinin
- CAS No.
- 9087-70-1
- Chemical Name
- Aprotinin
- Synonyms
- BPTI;Bovine pancreatic trypsin inhibitor;fosten;rp-9921;TRASYLOL;onquinin;repulson;riker52g;trazinin;zymofren
- CBNumber
- CB3329436
- Molecular Formula
- C284H432N84O78R2S7
- Formula Weight
- 6495.43988
- MOL File
- 9087-70-1.mol
Aprotinin Property
- Melting point:
- >234oC (dec.)
- storage temp.
- 2-8°C
- solubility
- glycerol: soluble3mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)
- form
- lyophilized powder
- color
- white
- Water Solubility
- Freely soluble in water and in aqueous buffers of low ionic strength.
- Merck
- 13,761
- Sequence
- H-Pro-Asp-Phe-Cys-Leu-Glu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Lys-Ala-Arg-Ile-Ile-Arg-Tyr-Phe-Tyr-Asn-Ala-Lys-Ala-Gly-Leu-Cys-Gln-Thr-Phe-Val-Tyr-Gly-Gly-Cys-Arg-Ala-Lys-Arg-Asn-Asn-Phe-Lys-Ser-Ala-Glu-Asp-Cys-Met-Arg-Thr-Cys-Gly-Gly-Ala-OH
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- RWLBZZCCAZDWSE-BNRYNCRGNA-N
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 42/43-36/37/38-20/21/22
- Safety Statements
- 22-45-36/37-36-26
- WGK Germany
- 1
- RTECS
- YN5080000
- F
- 10-21
- HS Code
- 35040000
- Hazardous Substances Data
- 9087-70-1(Hazardous Substances Data)
- Toxicity
- LD50 i.v. in mice: 2500000 kallikrein inhibitor units/kg (Trautschold)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- ROAPRO
- Product name
- Aprotinin
- Purity
- from bovine lung
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- ROAPRO
- Product name
- Aprotinin
- Purity
- from bovine lung
- Packaging
- 50mg
- Price
- $524
- Updated
- 2024/03/01
- Product number
- ROAPRO
- Product name
- Aprotinin
- Purity
- from bovine lung
- Packaging
- 100mg
- Price
- $775
- Updated
- 2024/03/01
- Product number
- A6103
- Product name
- Aprotinin bovine
- Purity
- recombinant,expressedinNicotiana(tobacco),≥5?TIU/mgprotein,≥98%(SDS-PAGE
- Packaging
- 1mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- A6103
- Product name
- Aprotinin bovine
- Purity
- recombinant,expressedinNicotiana(tobacco),≥5?TIU/mgprotein,≥98%(SDS-PAGE
- Packaging
- 25mg
- Price
- $469
- Updated
- 2024/03/01
Aprotinin Chemical Properties,Usage,Production
Description
Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM). It is a much weaker inhibitor of thrombin (Ki = 0.1-
Chemical Properties
white powder
Originator
Trasylol,Bayer
Uses
A potent protease inhibitor.Aprotinin acts as a reversible serine protease blocking and a binding agent. It is widely employed as an inhibitor of trypsin. It is also used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones. It is involved in the purification of urokinase, trypsin, and chymotrypsin on immobilized aprotinin. Further, it is used in the quantification of kallikrein activity in mixtures of esterases and proteases.
Uses
Aprotinin is largely used as an inhibitor of trypsin.
Manufacturing Process
1 kg of parotid of cattle, which were freed of fat and flesh are comminuted in
a meat chopper and twice extracted with 5 L of acetone. The acetone was
removed as far as possible by sucking off and the moist material is digested
for 2.5 hours in 1.2 L of 1 N acetic acid and 2.8 L of 96% ethanol at 50°C.
The filtrate containts about 230.000 inactivator units.
The alcoholic solution is concentrated to 1.2 L by evaporating in vacuo and
shaken with an equal amount of ether. Dark coloring matters and residues of
fat are thus dissolved. The aqueous phase is now mixed with acetone until a
precipitate occurs and the dissolved in dilute acetic acid. The solution is
brought to a weakly alkaline pH by addition of ammonia. It is then centrifuged
and the inactivator is precipitated with five times the amount of ethanol. The
yield amounts to about 180.000 kallikrein inactivator units in 0.4-0.5 g of
substance.
brand name
Trasylol (Bayer).
Therapeutic Function
Proteinase inhibitor
General Description
Trypsin inhibitor, pancreas type from bovine lung. It is known as Pancreatic trypsin inhibitor (BPTI). Aprotinin, also known as pancreatic trypsin inhibitor and trypsin-kallikrein inhibitor, is found to be expressed in lungs, spleen, liver, and pancreas. It is also found to be present in the free form in calf serum.
Biochem/physiol Actions
Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.
Safety Profile
Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.
storage
Store at +4°C
References
1. henry da, carless pa, moxey aj, et al. anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. cochrane database syst rev 2007; 4: cd001886.2. levi m, cromheecke me, de jonge e, et al. pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. lancet 1999; 354: 1940-7.3. sedrakyan a, treasure t, elefteriades ja. effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized
Aprotinin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aprotinin manufacturers
- Product
- Aprotinin 9087-70-1
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 90.0%Min. HPLC
- Supply Ability
- 10000
- Release date
- 2024-09-21
- Product
- Aprotinin 9087-70-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 1kg/month
- Release date
- 2021-05-31
- Product
- Aprotinin 9087-70-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04