ChemicalBook > CAS DataBase List > BESTATIN HYDROCHLORIDE

BESTATIN HYDROCHLORIDE

Product Name
BESTATIN HYDROCHLORIDE
CAS No.
65391-42-6
Chemical Name
BESTATIN HYDROCHLORIDE
Synonyms
BESTATIN HCL;Bestatin.HCI;Ubenimex HCl;Ubenimex-d7 HCl;BESTATIN HYDROCHLORIDE;Ubenimex hydrochloride;HYDROCHLORIDE,Ubenimex;Bestatin research grade;BESTATIN HYDROCHLORIDE USP/EP/BP;Bestatin-d7 HCl (Ubenimex-d7 HCl)
CBNumber
CB2172341
Molecular Formula
C16H25ClN2O4
Formula Weight
344.83
MOL File
65391-42-6.mol
More
Less

BESTATIN HYDROCHLORIDE Property

Melting point:
216-218 °C
storage temp. 
2-8°C
solubility 
H2O: 25 mg/mL, clear, colorless
form 
White to off-white powder.
color 
White
Water Solubility 
Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN 
4628066
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChIKey
XGDFITZJGKUSDK-UDYGKFQRSA-N
CAS DataBase Reference
65391-42-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
F 
3-10
HS Code 
29242995
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8385
Product name
Bestatin hydrochloride
Purity
≥98% (HPLC)
Packaging
1mg
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
B8385
Product name
Bestatin hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$164
Updated
2024/03/01
Sigma-Aldrich
Product number
10874515001
Product name
Bestatin
Purity
[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucinehydrochloride
Packaging
10mg
Price
$244
Updated
2022/05/15
TCI Chemical
Product number
B4000
Product name
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$194
Updated
2024/03/01
Alfa Aesar
Product number
J60384
Product name
Bestatin hydrochloride, 98%
Packaging
5mg
Price
$87.65
Updated
2024/03/01
More
Less

BESTATIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Uses

Bestatin Hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase. It is the salt form of Bestatin (B319500).

Uses

competitive aminopeptidase B inhibitor

Uses

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Uses

Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.

Definition

ChEBI: Bestatin (hydrochloride) is a peptide.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

in vivo

in a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) showed a significant inhibitory activity against the melanoma cell-induced angiogenesis. bestatin also inhibited the tube-like formation of human umbilical vein endothelial cells (huvecs). furthermore, after the orthotopic implantation of b16-bl6 melanoma cells into mice, bestatin administration (50-100 mg/kg/day, i.p) reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice [1].

References

1) Orning et al. (1991), Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes; J. Biol. Chem., 266 1375 2) Wang et al. (2010), The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor; Biol. Pharm. Bull., 33 1658

BESTATIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BESTATIN HYDROCHLORIDE Suppliers

Americas 1 China 91 Europe 4 France 1 Germany 5 India 7 Japan 2 Switzerland 3 United Kingdom 9 United States 30 Global 153
More
Less

View Lastest Price from BESTATIN HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Bestatin hydrochloride 65391-42-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Bestatin hydrochloride 65391-42-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
BESTATIN HYDROCHLORIDE 65391-42-6
Price
US $150.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2018-07-31

65391-42-6, BESTATIN HYDROCHLORIDERelated Search:

CARBOXYPEPTIDASE A CARBOXYPEPTIDASE B CARBOXYPEPTIDASE B Trypsin Chymotrypsin N-CARBOBENZOXY-DL-LEUCINE 1,3-Diamino-2-propanol Bestatin N-(2-HYDROXYETHYL)LACTAMIDE BESTATIN HYDROCHLORIDE (R)-(-)-4-PHENYL-2-BUTANOL D(+)-Phenylalaninol H-BETA-ALA-NH2 HCL 1,3-Dimethylbutylamine L-Leucine hydrochloride DIETHANOLAMINE HYDROCHLORIDE Betaine hydrochloride N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

  • N-[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE HYDROCHLORIDE
  • N-(3R-AMINO-2S-HYDROXY-1-OXO-4-PHENYLBUTYL)-L-LEUCINE, MONOHYDROCHLORIDE
  • [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HCL
  • [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HYDROCHLORIDE
  • (AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE HYDROCHLORIDE
  • BESTATIN HCL
  • BESTATIN HYDROCHLORIDE
  • N-(2S,3R-3-AMINO-2-HYDROXY-4-PHENYLBUTY- RYL)-L-LEUCINE HCL
  • Bestatin.HCI
  • N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine monohydrochloride
  • (S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid hydrochloride
  • L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-, hydrochloride (1:1)
  • Ubenimex Hydrochloride [for Biochemical Research]
  • Ubenimex hydrochloride
  • Bestatin research grade
  • Bestatin-d7 HCl (Ubenimex-d7 HCl)
  • Ubenimex-d7 HCl
  • HYDROCHLORIDE,Ubenimex
  • Bestatin hydrochloride, ≥98% (HPLC)
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride &gt
  • BESTATIN HYDROCHLORIDE USP/EP/BP
  • Ubenimex-d7 HClQ: What is Ubenimex-d7 HCl Q: What is the CAS Number of Ubenimex-d7 HCl
  • (4S,5R)-5-amino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenyl-D-norleucine hydrochloride
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride
  • (S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid hydrochloride[Ubenimex Hydrochloride
  • Ubenimex HCl，Bestatin hydrochloride
  • Ubenimex HCl
  • 65391-42-6
  • C16H24N2O4ClH
  • C16HH24N2O4xHCL
  • Antibiotics A-F
  • Antibiotics A to Z
  • Antibiotics
  • BioChemical
  • peptides
  • Bestatin
  • inhibitor
  • Pepetides