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Ozanimod

Product Name
Ozanimod
CAS No.
1306760-87-1
Chemical Name
Ozanimod
Synonyms
CS-2386;RPC1063;Ozanimod;RPC1063 Ozanimod;oxanimod(RPC1063);Ozanimod (RPC1063);Ozanimod USP/EP/BP;RPC1063;RPC-1063;RPC 1063;(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile;5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
CBNumber
CB42716147
Molecular Formula
C23H24N4O3
Formula Weight
404.46
MOL File
1306760-87-1.mol
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Ozanimod Property

Boiling point:
648.3±65.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
pka
14.73±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19922
Product name
Ozanimod
Purity
≥98%
Packaging
1mg
Price
$35
Updated
2021/03/22
Cayman Chemical
Product number
19922
Product name
Ozanimod
Purity
≥98%
Packaging
5mg
Price
$158
Updated
2021/03/22
Cayman Chemical
Product number
19922
Product name
Ozanimod
Purity
≥98%
Packaging
10mg
Price
$280
Updated
2021/03/22
Cayman Chemical
Product number
19922
Product name
Ozanimod
Purity
≥98%
Packaging
25mg
Price
$656
Updated
2021/03/22
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Ozanimod Chemical Properties,Usage,Production

Enzyme inhibitor

This orally available S1PR1 modulator (FW = 404.46 g/mol; CAS 1306760- 87-1; Solubility: 81 mg/mL DMSO; < 1 mg/mL H2O), also named RPC1063 and 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden- 4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile, selectively targets sphingosine 1-Phosphate (S1P) receptors, which mediate multiple processes, including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Ozanimod is specific for S1P1R (IC50 = 0.4 nM) and S1P5R, inducing S1P1R internalization and reversibly reducing the number of circulating B and CCR7+ T lymphocytes in vivo. It shows high oral bioavailability and volume of distribution, and a circulatory half-life that supports once daily dosing. Oral ozanimod reduced inflammation and disease parameters in three autoimmune disease models, commending its use in the treatment of relapsing multiple sclerosis (RMS) and inflammatory bowel disease (IBD). Indeed, the safety and efficacy of this modulator ozanimod in relapsing multiple sclerosis is indicated on the basis of a randomized, placebo-controlled, Phase 2 trial. Other SIPR1-directed immunomodulators include laquinimod, ponesimod, and siponimod.

Ozanimod Preparation Products And Raw materials

Raw materials

Preparation Products

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Ozanimod Suppliers

Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1722
Advantage
58
Senova Technology Co., Ltd.
Tel
86-13723419324
Email
bruce@senovatech.com
Country
China
ProdList
32
Advantage
58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Email
xingcanyaoye@sina.com;
Country
China
ProdList
2330
Advantage
58
Nanjing YakeLun Pharmaceutical Co., Ltd.
Tel
025-66096093-
Fax
QQ3165145969
Email
sales@accoron.com
Country
China
ProdList
3954
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
Haoyuan Chemexpress Co., Ltd.
Tel
86-21-58998985
Fax
(86) 21-58955996
Email
apisales@chemexpress.com.cn
Country
China
ProdList
7557
Advantage
61
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86110680
Email
sales@allyrise.com
Country
China
ProdList
1092
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
19212
Advantage
56
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View Lastest Price from Ozanimod manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ozanimod 1306760-87-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-06
Wuhan Nutra Biotechnology Co.,Ltd
Product
Ozanimod 1306760-87-1
Price
US $600.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-23
Longyan Tianhua Biological Technology Co., Ltd
Product
Ozanimod 1306760-87-1
Price
US $20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2020-11-11

1306760-87-1, OzanimodRelated Search:


  • Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base)
  • Ozanimod (RPC1063)
  • Ozanimod
  • RPC1063
  • Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-
  • 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
  • (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile
  • oxanimod(RPC1063)
  • RPC1063 Ozanimod
  • CS-2386
  • RPC1063;RPC-1063;RPC 1063
  • Ozanimod USP/EP/BP
  • 1306760-87-1
  • 13067-87-1