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Semapimod

Product Name
Semapimod
CAS No.
352513-83-8
Chemical Name
Semapimod
Synonyms
AXD-455;Cni-1493;Cni 1493;CPSI 2364;semapimod;N,N'-Bis[3,5-bis[1-[(aminoiminomethyl)hydrazono]ethyl]phenyl]decanediamide;Decanediamide, N1,N10-bis[3,5-bis[1-[2-(aminoiminomethyl)hydrazinylidene]ethyl]phenyl]-;N,N'-bis[3-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]-5-[(Z)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide
CBNumber
CB91856072
Molecular Formula
C34H52N18O2
Formula Weight
744.9
MOL File
352513-83-8.mol
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Semapimod Property

Density 
1.39
pka
14.28±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
INB0000028
Product name
CNI-1493
Purity
95.00%
Packaging
5MG
Price
$497.05
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005310
Product name
SEMAPIMOD
Purity
95.00%
Packaging
5MG
Price
$497.27
Updated
2021/12/16
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Semapimod Chemical Properties,Usage,Production

Uses

Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3].

in vivo

Semapimod (5 mg/kg; i.p; daily for 2 weeks) ameliorates endothelial dysfunction in Obese Zucker (OZ) rats[1].
Semapimod restores AM-induced akt phosphorylation and cGMP production in OZ rats[1].
Semapimod (6 mg/kg/day, Intracranially for 1 week) inhibits glioblastoma cell invasion in vivo[4].
Semapimod (intracranially administered, 2 weeks) semapimos strongly increases the survival of GL261 tumor-bearing animals in combination with radiation, but has no significant benefit in the absence of radiation[4].

Animal Model:Male OZ rats[1]
Dosage:5 mg/kg
Administration:I.p; daily for 2 weeks
Result:Restored endothelium-dependent vasorelaxation in OZ rats.
Animal Model:C57Bl/6 mice (GL261 cells were orthotopically implanted)[4]
Dosage:6 mg/kg/day
Administration:Intracranially for 1 week, delivered via an osmotic pump
Result:Inhibited tumor cell invasion by more than 75%.

IC 50

CD40; IL-1β; IL-6; p38 MAPK

References

[1] Nishimatsu H, et al. Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats. Hypertens Res. 2008;31(4):737‐743. DOI:10.1291/hypres.31.737
[2] Wehner S, Set al. Inhibition of p38 mitogen-activated protein kinase pathway as prophylaxis of postoperative ileus in mice. Gastroenterology. 2009;136(2):619‐629. DOI:10.1053/j.gastro.2008.10.017
[3] Wang J, et al. Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol. 2016;196(12):5130‐5137. DOI:10.4049/jimmunol.1502135
[4] Miller IS, et al. Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia. PLoS One. 2014 May 9;9(5):e95885. DOI:10.1371/journal.pone.0095885

Semapimod Preparation Products And Raw materials

Raw materials

Preparation Products

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Semapimod Suppliers

China 8 United States 5 Global 13
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Suzhou Meishi Biotechnology Co., Ltd.
Tel
1173954148q
Email
meishipharma@126.com
Country
China
ProdList
20033
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054;
Email
trendseenbio@gmail.com
Country
China
ProdList
9069
Advantage
58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
19353112242
Email
1816280386@qq.com
Country
China
ProdList
8045
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58

352513-83-8, SemapimodRelated Search:

Ethyl acrylate Ethylbenzene Ethylparaben Phenylhydrazine 1,5-Diphenylcarbazide 3-Aminobenzenesulfonamide Sulfanilamide PHENYL VALERATE Polyacrylamide Ethyl cellulose Ethanol Ethyl acetate N,N-Dimethylformamide Fingolimod hydrochloride Tapinarof Diethyl ether Methylhydrazine Semapimod

  • semapimod
  • N,N'-Bis[3,5-bis[1-[(aminoiminomethyl)hydrazono]ethyl]phenyl]decanediamide
  • Cni 1493
  • Cni-1493
  • CPSI 2364
  • N,N'-bis[3-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]-5-[(Z)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide
  • AXD-455
  • Decanediamide, N1,N10-bis[3,5-bis[1-[2-(aminoiminomethyl)hydrazinylidene]ethyl]phenyl]-
  • 352513-83-8
  • C34H52N18O2
  • Pharmaceutical