Roquinimex
- Product Name
- Roquinimex
- CAS No.
- 84088-42-6
- Chemical Name
- Roquinimex
- Synonyms
- FCF89;CS-1231;LS-2616;LINOMIDE;ABR212616;ROQUINIMEX;PNU 212616;Roquinimex(Linomide);N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
- CBNumber
- CB2391777
- Molecular Formula
- C18H16N2O3
- Formula Weight
- 308.33
- MOL File
- 84088-42-6.mol
Roquinimex Property
- Melting point:
- 200-204°
- Boiling point:
- 436.2±45.0 °C(Predicted)
- Density
- 1.357±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: 11 mg/mL
- form
- solid
- pka
- 4.50±1.00(Predicted)
- Merck
- 14,8259
N-Bromosuccinimide Price
- Product number
- L0270
- Product name
- Linomide
- Purity
- >98.0%(HPLC)
- Packaging
- 10mg
- Price
- $170
- Updated
- 2024/03/01
- Product number
- J65453
- Product name
- Linomide
- Packaging
- 10mg
- Price
- $174.65
- Updated
- 2024/03/01
- Product number
- 30206
- Product name
- Roquinimex
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 30206
- Product name
- Roquinimex
- Packaging
- 100mg
- Price
- $700
- Updated
- 2024/03/01
- Product number
- 30206
- Product name
- Roquinimex
- Packaging
- 10mg
- Price
- $168
- Updated
- 2024/03/01
Roquinimex Chemical Properties,Usage,Production
Description
Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.
Uses
Biological response modifier; immunomodulator.
Uses
An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats
Definition
ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide.
Biological Activity
Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .
Roquinimex Preparation Products And Raw materials
Raw materials
Preparation Products
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