ChemicalBook > CAS DataBase List > CIVENTICHEM CV-4057

CIVENTICHEM CV-4057

Product Name
CIVENTICHEM CV-4057
CAS No.
248281-84-7
Chemical Name
CIVENTICHEM CV-4057
Synonyms
LAQ;CS-82;ABR 215062;ABR-215062;Lanquinimod;CIVENTICHEM;oro-N-ethyL;-2-oxo-N-phenyL;Laquinimod, >=98%;ine-3-carboxamide
CBNumber
CB7836628
Molecular Formula
C19H17ClN2O3
Formula Weight
356.8
MOL File
248281-84-7.mol
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CIVENTICHEM CV-4057 Property

Melting point:
201 °C (decomp)
Boiling point:
484.8±45.0 °C(Predicted)
Density 
1.395±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
pka
4.50±1.00(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2504
Product name
Laquinimod
Purity
≥98% (HPLC)
Packaging
10MG
Price
$40.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2504
Product name
Laquinimod
Purity
≥98% (HPLC)
Packaging
50MG
Price
$386
Updated
2024/03/01
Sigma-Aldrich
Product number
CVT00095
Product name
5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide
Packaging
1g
Price
$724
Updated
2024/03/01
Cayman Chemical
Product number
24187
Product name
Laquinimod
Purity
≥98%
Packaging
100mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
24187
Product name
Laquinimod
Purity
≥98%
Packaging
250mg
Price
$172
Updated
2024/03/01
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CIVENTICHEM CV-4057 Chemical Properties,Usage,Production

Description

Laquinimod (248281-84-7) is an immunomodulator1 that inhibits inflammation2 and autoimmunity3,4 via activation of the aryl hydrocarbon receptor (AhR)5. It has been investigated as a treatment for multiple sclerosis6 and has shown efficacy in Huntington’s disease models7,8.

Definition

ChEBI: Laquinimod is an aromatic amide.

in vitro

abr-215062 was shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (eae) [1].

in vivo

abr-215062 dose-dependently inhibited disease and showed better disease inhibitory effects as compared to roquinimex (linomide). furthermore, abr-215062 inhibited the inflammation of both cd4+ t cells and macrophages into central nervous tissues [2].

References

J?nsson et al. (2004), Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure-Activity Relationship; Med. Chem. 47 2075 Rothhammer et al. (2021); Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS, Neurol. Neuroimmunol. Neuroinflamm., 8 e946 Pitarokoili et al. (2014), Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis; Neuroimmunol., 274 38 Ott et al. (2019), Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity; Neuroinflammation, 16 49 Kaye et al. (2016), Laquinimod arrests experimental autoimmune encephalitis by activating the aryl hydrocarbon receptor; Natl. Acad. Sci. USA., 113 E6145 Th?ne and Linker (2016), Laquinimod in the treatment of multiple sclerosis: a review of the data so far; Drug Des. Devel. Ther., 10 1111 Dobson et al. (2016), Laquinimod dampens hyperactive cytokine production in Huntington’s disease patient myeloid cells; Neurochem., 137 782 Garcia-Miralles et al. (2016), Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease; Rep., 6 31652

CIVENTICHEM CV-4057 Preparation Products And Raw materials

Raw materials

Preparation Products

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CIVENTICHEM CV-4057 Suppliers

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248281-84-7, CIVENTICHEM CV-4057Related Search:

Tacrolimus WY-14643 Astemizole BESTATIN HYDROCHLORIDE Pidotimod Semapimod Iguratimod BAF-312(SiponiMod) tasquinimod Tiprotimod APILIMOD Ozanimod Fingolimod hydrochloride Tapinarof Glatiramer acetate Roquinimex CIVENTICHEM CV-4057 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID

  • CIVENTICHEM CV-4057
  • LAQUINIMOD,5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL-PHENYL-AMIDE
  • ABR-215062 (Laquinimod)
  • CIVENTICHEM
  • CS-82
  • ABR215062; ABR 215062 (LAQUINIMOD)
  • 5-Chloro-4-hydroxy-1-Methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl-phenyl-aMide
  • LaquiniMod, SAIK-MS coMpound, ABR-215062
  • 5-Chloro-4-hydroxy-1-methyl-2-oxo-N-ethyl-N-phenyl-1,2-dihydroquinoline-3-carboxamide
  • Lanquinimod
  • LaquiniMod,CiventicheMCV-4057,5-Chloro-4-hydroxy-1-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylicacidethylphenylaMide
  • 5-chloro-N-ethyl-4-hydroxy-1-Methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxaMide
  • ABR 215062
  • ABR-215062
  • LaquiniMod (ABR-215062)
  • LAQ
  • Laquinimod potassium salt
  • 5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide
  • Laquinimod, >=98%
  • 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
  • -1,2-dihydroquinoL
  • -2-oxo-N-phenyL
  • -4-hydroxy-1-methyL
  • ine-3-carboxamide
  • oro-N-ethyL
  • 3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-
  • 5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihyd...
  • inhibit,multiple sclerosis,relapsing remitting,carboxamide,Nuclear factor-kappaB,Apoptosis,Inhibitor,ABR 215062,Nuclear factor-κB,immunomodulator,ABR215062,chronic progressive,neurodegenerative disease,inflammation,NF-κB,Laquinimod,Orally,neurodegeneration
  • 248281-84-7
  • Inhibitors
  • api
  • Heterocycles