NOTUMib-1 Property

storage temp. 

-20° (des.)

solubility 

Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).

form 

solid

color 

Beige

Stability:

Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Hazard and Precautionary Statements (GHS)

NOTUMib-1 Chemical Properties,Usage,Production

Description

NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling.1?NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 μM, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity.2?NOTUM inhibitors have potential as new therapeutics for degenerative diseases.3

Uses

NOTUMib-1 is a NOTUM inhibitor. NOTUM inhibitors have potentials as new therapeutics for degenerative diseases.

References

1) Zhang?et al.?(2016),?Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes Tiki and Notum; Methods Mol. Biol.,?1481?29 2) Atkinson?et al.?(2019),?Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen; Med. Chem. Commun.?10?1361 3) Suciu?et al.?(2018),?Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling; ACS Med. Chem. Lett.,?9?563