5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER
- Product Name
- 5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER
- CAS No.
- 17449-48-8
- Chemical Name
- 5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER
- Synonyms
- DIMETHYL 5-FLUOROISOPHTHALATE;5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER;dimethyl 5-fluorobenzene-1,3-dicarboxylate;1,3-Benzenedicarboxylic acid, 5-fluoro-, 1,3-dimethyl ester
- CBNumber
- CB02456573
- Molecular Formula
- C10H9FO4
- Formula Weight
- 212.17
- MOL File
- 17449-48-8.mol
5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER Property
- Melting point:
- 56.5-57 °C
- Boiling point:
- 288.3±30.0 °C(Predicted)
- Density
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D465768
- Product name
- Dimethyl5-Fluoroisophthalate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 6608AJ
- Product name
- Dimethyl5-fluoroisophthalate
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- CM194483
- Product name
- Dimethyl5-fluoroisophthalate
- Purity
- 95%
- Packaging
- 5g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- CD12132772
- Product name
- Dimethyl5-fluoroisophthalate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $263
- Updated
- 2021/12/16
- Product number
- 17449488
- Product name
- Dimethyl5-fluoroisophthalate
- Packaging
- 5g
- Price
- $271.32
- Updated
- 2021/12/16
5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER Chemical Properties,Usage,Production
Uses
Dimethyl 5-Fluoroisophthalate is used as a reactant in the preparation of quinazoline compounds as B-Raf inhibitors.
Synthesis
67-56-1
1583-66-0
17449-48-8
General procedure for the synthesis of dimethyl 5-fluoroisophthalate from methanol and 5-fluoroisophthalic acid: to a solution of 5-fluoroisophthalic acid (1.3 g, 7.1 mmol) in methanol (30 ml) was added concentrated sulfuric acid (0.25 ml). The reaction mixture was heated to reflux for 12 hours. After completion of the reaction, methanol was removed by distillation under reduced pressure. The residue was neutralized with saturated sodium bicarbonate solution and subsequently extracted with dichloromethane. The organic phase was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give dimethyl 5-fluoroisophthalate 1.25 g (83% yield) as a white solid. Nuclear magnetic resonance hydrogen spectroscopy (NMR) data: δ 8.42 (s, 1H), 7.88 (d, 2H), 3.90 (s, 6H).
References
[1] Patent: WO2007/71963, 2007, A2. Location in patent: Page/Page column 54
5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER manufacturers
- Product
- 5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER 17449-48-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 100kg
- Release date
- 2020-02-01