5-FLUOROPHTALIC ACID
- Product Name
- 5-FLUOROPHTALIC ACID
- CAS No.
- 1583-66-0
- Chemical Name
- 5-FLUOROPHTALIC ACID
- Synonyms
- Nsc302311;JACS-1583-66-0;5-FLUOROPHTALIC ACID;5-FLUORO-ISOPHTHALIC ACID;5-Fluorobenzene-1,3-dicarboxylic acid;1,3-Benzenedicarboxylic acid, 5-fluoro-
- CBNumber
- CB2678409
- Molecular Formula
- C8H5FO4
- Formula Weight
- 184.12
- MOL File
- 1583-66-0.mol
5-FLUOROPHTALIC ACID Property
- Melting point:
- 295-297℃
- Boiling point:
- 407.7±30.0 °C(Predicted)
- Density
- 1.551
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.19±0.10(Predicted)
- form
- solid
- color
- Off-white
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2917399590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F592363
- Product name
- 5-FluoroisophthalicAcid
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- PC908867
- Product name
- 5-Fluoroisophthalicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- J98009
- Product name
- 5-Fluoroisophthalicacid
- Packaging
- 25g
- Price
- $480
- Updated
- 2021/12/16
- Product number
- PC908867
- Product name
- 5-Fluoroisophthalicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- HCH0028553
- Product name
- 5-FLUOROISOPHTHALIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1382.54
- Updated
- 2021/12/16
5-FLUOROPHTALIC ACID Chemical Properties,Usage,Production
Uses
5-Fluoroisophthalic Acid is a useful research chemical.
Synthesis
461-97-2
1583-66-0
General Steps: 1. 1.9 g (15.3 mmol) of 3,5-dimethylfluorobenzene was dissolved in a solvent mixture of about 13.5 mL of pyridine and about 9.5 mL of water under mild reflux conditions. 2. 13.8 g (87.3 mmol) of potassium permanganate (KMnO4) was added to the above solution in batches. 3. The reaction mixture was refluxed for about 7 hours to ensure complete reaction. 4. Upon completion of the reaction, an appropriate amount of sodium sulfite was added to quench the unreacted potassium permanganate. 5. Filter the reaction mixture while hot to remove insoluble impurities. 6. 6. To the filtrate, 1N hydrochloric acid (HCl) was slowly added to adjust the pH to 3. 7. 7. The filtrate was washed with ethyl acetate (EtOAc) and subsequently saturated with sodium chloride (NaCl). 8. The aqueous phase was extracted 3-4 times using a solvent mixture consisting of 80 mL of chloroform (CHCl3), 10 mL of methanol (MeOH) and 10 mL of water (H2O). 9. All organic extracts were combined and dried with anhydrous sodium sulfate. 10. The dried organic phase was filtered and the filtrate was concentrated to give about 400 mg (14% yield) of 5-fluoroisophthalic acid as a light yellow solid.
References
[1] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 55; 60
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 3, p. 529 - 532
[3] Patent: US2003/181334, 2003, A1
5-FLUOROPHTALIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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