ChemicalBook > CAS DataBase List > PHA 767491 HYDROCHLORIDE

PHA 767491 HYDROCHLORIDE

Product Name
PHA 767491 HYDROCHLORIDE
CAS No.
845714-00-3
Chemical Name
PHA 767491 HYDROCHLORIDE
Synonyms
CS-229;CAY10572;PHA-767491;PHA-767491HCL;CAY10572(PHA-767491);PHA 767491;PHA-767491;PHA-767491 (CAY10572);PHA 767491 HYDROCHLORIDE;PHA 767491 HYDROCHLORIDE USP/EP/BP;PHA-767491;CAY10572;PHA767491;PHA 767491
CBNumber
CB02458643
Molecular Formula
C12H11N3O
Formula Weight
213.24
MOL File
845714-00-3.mol
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PHA 767491 HYDROCHLORIDE Property

Density 
1.287
storage temp. 
Desiccate at RT
solubility 
insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO
form 
solid
Stability:
Hygroscopic
CAS DataBase Reference
845714-00-3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18218
Product name
PHA-767491
Purity
≥98%
Packaging
5mg
Price
$35
Updated
2021/12/16
Cayman Chemical
Product number
18218
Product name
PHA-767491
Purity
≥98%
Packaging
10mg
Price
$60
Updated
2021/12/16
Cayman Chemical
Product number
18218
Product name
PHA-767491
Purity
≥98%
Packaging
25mg
Price
$140
Updated
2021/12/16
Cayman Chemical
Product number
18218
Product name
PHA-767491
Purity
≥98%
Packaging
50mg
Price
$245
Updated
2021/12/16
Tocris
Product number
3140
Product name
PHA 767491 hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$635
Updated
2021/12/16
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PHA 767491 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

PHA 767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).

Uses

Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. PHA 767491 HYDROCHLORIDE is a potent inhibitor of Cdc7 kinase with an IC50 value of 10 nM in the presence of 1.5 μM ATP. At 10 μM, PHA 767491 HYDROCHLORIDE induces apoptotic cell death in multiple cancer cell types. PHA 767491 HYDROCHLORIDE also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression, with an IC50 value of 34 nM.[Cayman Chemical]

Definition

ChEBI: 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one is a pyrrolopyridine.

Biological Activity

Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC 50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC 50 ~ 0.86 - 5.87 μ M) and induces apoptosis in a p53-independent manner in vivo . Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC 50 = 171 nM).

target

cdc7

PHA 767491 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PHA 767491 HYDROCHLORIDE Suppliers

China 78 United Kingdom 1 United States 18 Global 97
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from PHA 767491 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
PHA 767491 HYDROCHLORIDE 845714-00-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

845714-00-3, PHA 767491 HYDROCHLORIDERelated Search:

Selumetinib Alectinib Saracatinib Dabrafenib LDC000067 Roscovitine

  • PHA-767491
  • CAY10572
  • 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one
  • PHA 767491 HYDROCHLORIDE
  • 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride
  • 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
  • 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
  • PHA-767491HCL
  • PHA-767491;CAY10572;PHA767491;PHA 767491
  • PHA-767491 (CAY10572)
  • PHA 767491;PHA-767491
  • CS-229
  • CAY10572(PHA-767491)
  • 4H-Pyrrolo[3,2-c]pyridin-4-one, 1,5,6,7-tetrahydro-2-(4-pyridinyl)-
  • PHA 767491 HYDROCHLORIDE USP/EP/BP
  • PHA-767491 PHA767491 Dihydrochloride Salt
  • 845714-00-3
  • C12H11N3OHCl
  • Inhibitors