2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL

Product Name: 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
CAS No.: 760990-08-7
Chemical Name: 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
Synonyms: 3-Fluoro-4-hydroxyphenylboronic acid,pinacol ester;3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%;2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL;Phenol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB02459392
Molecular Formula: C12H16BFO3
Formula Weight: 238.06
MOL File: 760990-08-7.mol

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2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Property

Melting point:: 99.3-100.2 °C
Boiling point:: 324.9±32.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.39±0.35(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 760990-08-7

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: F595358
Product name: 3-Fluoro-4-hydroxyphenylboronicacid,pinacolester
Packaging: 500mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: X0984
Product name: 3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging: 10g
Price: $521
Updated: 2021/12/16

AK Scientific

Product number: J98428
Product name: 3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging: 10g
Price: $390
Updated: 2021/12/16

AK Scientific

Product number: J98428
Product name: 3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging: 25g
Price: $780
Updated: 2021/12/16

AK Scientific

Product number: X0984
Product name: 3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging: 1g
Price: $101
Updated: 2021/12/16

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2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Chemical Properties,Usage,Production

Uses

3-Fluoro-4-hydroxyphenylboronic acid, pinacol ester

Synthesis

2105-94-4

73183-34-3

760990-08-7

4-Bromo-2-fluorophenol (1.9 g, 9.9 mmol), bis(pinacolato)diboron (2.9 g, 11.4 mmol), potassium acetate (3.90 g, 39.7 mmol), and DPPF (0.27 g, 0.49 mmol) were used as raw materials and dissolved in 32 mL 1,4-dioxane. Nitrogen was passed into the solution for 5 min to deoxidize. Subsequently, PdCl2(dppf)-DCM (0.4 g, 0.49 mmol) was added and the reaction mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and purified by column chromatography to afford the target product 3-fluoro-4-hydroxyphenylboronic acid pinacol ester (2.2 g, 93% yield).1H NMR (CDCl3) δ 7.49 (2H, m), 6.98 (1H, t), 5.31 (1H, brs), 1.33 (12H, s).

References

[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0417
[2] Patent: US2010/324068, 2010, A1. Location in patent: Page/Page column 30
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 432; 433; 434
[4] Patent: CN105384638, 2016, A. Location in patent: Paragraph 0678; 0679; 0680; 0681
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497

2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Suppliers

Canada 1 China 59 India 3 United States 6 Global 69

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View Lastest Price from 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL manufacturers

R&D Scientific Inc.

Product: 3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester 760990-08-7
Price: US $350.00/g
Min. Order: 1g
Purity: 97
Supply Ability: 50 Kg
Release date: 2024-02-12

Career Henan Chemical Co

Product: 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 760990-08-7
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 1kg; 5kg
Release date: 2020-02-03

760990-08-7, 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOLRelated Search:

2,4,6-TriMethoxyphenylboronic acid, pinacol ester 2-Aminopyridine-5-boronic acid, pinacol ester 4,4,5,5-tetramethyl-2-(4-nitronaphthalen-1-yl)-1,3,2-dioxaborolane 3-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol 2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol 3-Chloro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-amine 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER 3-Chloro-4-hydroxyphenylboronic acid, pinacol ester 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL

3-Fluoro-4-hydroxyphenylboronic acid,pinacol ester

3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%

Phenol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

760990-08-7