N-Methyl-2-aminopyridine-3-carboxamide
- Product Name
- N-Methyl-2-aminopyridine-3-carboxamide
- CAS No.
- 870997-87-8
- Chemical Name
- N-Methyl-2-aminopyridine-3-carboxamide
- Synonyms
- N-Methyl-2-aminonicotinamide;2-Amino-N-methylnicotinamide;N-methyl-2-amino-3-nicotinamide;2-amino-N-methylpyridine-3-carboxamide;N-Methyl-2-aminopyridine-3-carboxamide;3-Pyridinecarboxamide,2-amino-N-methyl-;N-Methyl-2-aminopyridine-3-carboxamide ISO 9001：2015 REACH
- CBNumber
- CB02462174
- Molecular Formula
- C7H9N3O
- Formula Weight
- 151.17
- MOL File
- 870997-87-8.mol
N-Methyl-2-aminopyridine-3-carboxamide Property
- Melting point:
- 149 - 151°C
- Boiling point:
- 373.1±27.0 °C(Predicted)
- Density
- 1.206
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 14.44±0.46(Predicted)
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- A636380
- Product name
- 2-Amino-N-methylpyridine-3-carboxamide
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A636380
- Product name
- 2-Amino-N-methylpyridine-3-carboxamide
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3745AC
- Product name
- 2-Amino-N-methylnicotinamide
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CHM0079763
- Product name
- N-METHYL-2-AMINONICOTINAMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- 3745AC
- Product name
- 2-Amino-N-methylnicotinamide
- Packaging
- 100mg
- Price
- $73
- Updated
- 2021/12/16
N-Methyl-2-aminopyridine-3-carboxamide Chemical Properties,Usage,Production
Uses
2-Amino-N-methylpyridine-3-carboxamide is used in preparation of triazolopyrazine derivatives and analogs for use as c-MET kinase activity inhibitors.
Synthesis
5345-47-1
593-51-1
870997-87-8
To 2-aminonicotinic acid (2.0 g, 14.5 mmol) and methylamine hydrochloride (1.47 g, 1.5 eq.) were added EDC (4.49 g, 1.5 eq.), HOBt (2.35 g, 1.2 eq.), and DIEA (7.6 mL, 3.0 eq.) sequentially in DMF (20 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the crude product was concentrated and the residue was dissolved in EtOAc. The organic phase was washed with saturated NaHCO3 solution. After removing the solvent under reduced pressure, the crude product was purified by silica gel column chromatography (eluent: 0%-20% MeOH/DCM) to afford the target compound 2-amino-N-methylnicotinamide (2.16 g, isolated yield 98%).
References
[1] Patent: WO2008/115369, 2008, A2. Location in patent: Page/Page column 130
N-Methyl-2-aminopyridine-3-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Methyl-2-aminopyridine-3-carboxamide Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from N-Methyl-2-aminopyridine-3-carboxamide manufacturers
- Product
- N-Methyl-2-aminopyridine-3-carboxamide 870997-87-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-07