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2-BROMO-4-METHOXYBENZALDEHYDE

Product Name
2-BROMO-4-METHOXYBENZALDEHYDE
CAS No.
43192-31-0
Chemical Name
2-BROMO-4-METHOXYBENZALDEHYDE
Synonyms
B90014;2-Bromo-p-anisaldehyde;3-Bromo-4-formylanisole;4-methoxy-2-bromo benzaldehyde;Benzaldehyde, 2-broMo-4-Methoxy-;2-BroMo-4-Methoxybenzaldehyde, 97+%;3-Bromo-4-formylanisole, 2-Bromo-p-anisaldehyde
CBNumber
CB02464305
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
43192-31-0.mol
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2-BROMO-4-METHOXYBENZALDEHYDE Property

Melting point:
68-69℃
Boiling point:
284℃
Density 
1.522
Flash point:
126℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Solid
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C8H7BrO2/c1-11-7-3-2-6(5-10)8(9)4-7/h2-5H,1H3
InChIKey
ODISAUHBLBVQKC-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(OC)C=C1Br
CAS DataBase Reference
43192-31-0
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
2912490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
777544
Product name
2-Bromo-4-methoxybenzaldehyde
Purity
97%
Packaging
1g
Price
$47.02
Updated
2025/07/31
TRC
Product number
B699928
Product name
2-Bromo-4-methoxybenzaldehyde
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-9-01
Product name
2-Bromo-4-methoxybenzaldehyde
Purity
95%
Packaging
5G
Price
$47
Updated
2021/12/16
Apolloscientific
Product number
OR301068
Product name
2-Bromo-4-methoxybenzaldehyde
Purity
98%
Packaging
5g
Price
$43
Updated
2021/12/16
Matrix Scientific
Product number
074240
Product name
2-Bromo-4-methoxybenzaldehyde
Purity
95+%
Packaging
1g
Price
$25
Updated
2021/12/16
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2-BROMO-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

2-Bromo-4-methoxybenzaldehyde is an organic compound that is often used as an intermediate in organic synthesis, especially in pharmaceutical and pesticide chemistry.

Synthesis

123-11-5

43192-31-0

The general procedure for the synthesis of 2-bromo-4-methoxybenzaldehyde from p-methoxybenzaldehyde is as follows: Example 4: Scheme C1; n-Butyl lithium (n-BuLi, 1 equiv, 147 mmol, 59 mL, 2.5 M) was slowly added dropwise to an anhydrous tetrahydrofuran (THF, 80 mL) solution of trimethylethylenediamine (TMEDA, 1.1 equiv, 162 mmol, 17.0 g) under stirring at -20 °C. After 15 min, p-methoxybenzene formaldehyde (1 eq, 147 mmol, 20.0 g) and stirring was continued for 15 min, followed by dropwise addition of n-butyllithium (n-BuLi, 3 eq, 441 mmol, 176 mL, 2.5 M). The reaction mixture was stirred at 0 °C for 20 hours. The solution was cooled to -78 °C, carbon tetrabromide (2.7 eq, 397 mmol, 131.6 g) was added, and the solution was allowed to warm slowly to room temperature. A 10% aqueous hydrochloric acid solution was added and extracted with dichloromethane. The organic extracts were combined and washed sequentially with saturated aqueous sodium thiosulfate, water and brine. The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: heptane/ethyl acetate, 9:1) to afford the target compound C1.2 as a white solid (8 g, yield = 25%). 1H-NMR (δ, DMSO-D6): 3.89 (3H, s), 7.13 (1H, dd, J=8.7,2.4 Hz), 7.35 (1H, d, J=2.4 Hz), 7.83 (1H, d, J=8.7 Hz), 10.10 (1H, s) ppm.

References

[1] Tetrahedron, 2012, vol. 68, # 40, p. 8463 - 8471
[2] Chemical Communications, 2005, # 46, p. 5793 - 5795
[3] Organic and Biomolecular Chemistry, 2007, vol. 5, # 1, p. 143 - 150
[4] Organic Letters, 2011, vol. 13, # 14, p. 3686 - 3689
[5] Patent: WO2008/37784, 2008, A1. Location in patent: Page/Page column 37

2-BROMO-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-METHOXYBENZALDEHYDE Suppliers

China 139 India 7 South Korea 1 United Kingdom 2 United States 12 Global 161
Alfa Aesar
Tel
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Fax
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Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2-BROMO-4-METHOXYBENZALDEHYDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-BROMO-4-METHOXYBENZALDEHYDE 43192-31-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-BROMO-4-METHOXYBENZALDEHYDE 43192-31-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-BROMO-4-METHOXYBENZALDEHYDE 43192-31-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

43192-31-0, 2-BROMO-4-METHOXYBENZALDEHYDERelated Search:

6-Bromoveratraldehyde 2-Bromo-4'-methoxyacetophenone 1-(8-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)ETHAN-1-ONE 6-Bromopiperonal 4-ACETOXY-2-BROMO-5-METHOXYBENZALDEHYDE 98 2-BROMO-4,5-DIMETHOXYBENZOIC ACID 2-Bromoisovanillin 6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID 2-BROMO-4,5-ETHYLENEDIOXYACETOPHENONE (7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)(2-METHOXYPHENYL)METHANONE (8-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)(PHENYL)METHANONE (7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)(4-NITROPHENYL)METHANONE (8-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)(4-BROMOPHENYL)METHANONE 1-(7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-2-PHENYLETHAN-1-ONE (7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)(4-METHYLPHENYL)METHANONE (7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)(PHENYL)METHANONE (7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)(4-BROMOPHENYL)METHANONE (7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)(4-CHLOROPHENYL)METHANONE

  • 3-Bromo-4-formylanisole, 2-Bromo-p-anisaldehyde
  • Benzaldehyde, 2-broMo-4-Methoxy-
  • 2-BroMo-4-Methoxybenzaldehyde, 97+%
  • 3-Bromo-4-formylanisole
  • B90014
  • 2-Bromo-p-anisaldehyde
  • 4-methoxy-2-bromo benzaldehyde
  • 43192-31-0