4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL

Product Name: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL
CAS No.: 223251-25-0
Chemical Name: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL
Synonyms: Bazedoxifene intermediate;Landiolol Impurity 13 Heoxalate;-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL;4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL;1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCI;1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl;1-[2-[4-(Chloromethyl)phenoxy]-ethyl]hexahydro-1H-azepine HCl;1-{2-[4-(Chloromethyl)phenoxy]ethyl}azepane hydrochloride (1:1);1-{2-[4-(Chloromethyl)phenoxy]ethyl}azepane hydrochloride (1...;1-[2-[4-(ChloroMethyl)phenoxy]ethyl]hexahydro-1H-azepine hydrochloride
CBNumber: CB02466521
Molecular Formula: C15H23Cl2NO
Formula Weight: 304.26
MOL File: 223251-25-0.mol

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4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Off-white to gray Solid

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C371065
Product name: 1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepineHydrochloride
Packaging: 5g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC15590
Product name: 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
Packaging: 5G
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 3002AH
Product name: 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepanehydrochloride
Packaging: 1g
Price: $67
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC15590
Product name: 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
Packaging: 10g
Price: $100
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 55812
Product name: 1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepineHCl
Packaging: 5G
Price: $190
Updated: 2021/12/16

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4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Chemical Properties,Usage,Production

Uses

1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepine Hydrochloride is a useful synthetic intermediate in the synthesis of Bazedoxifene (B129250); a nonsteroidal selective estrogen receptor modulator (SERM). Also used as an antiosteoporotic.

Synthesis

223251-16-9

223251-25-0

S4: (4-(2-(Azepan-1-yl)ethoxy)phenyl)methanol (561 g) obtained from step S3 was dissolved in 1.2 L of tetrahydrofuran and cooled to 0 °C. Thionyl chloride (320 g) was added slowly and dropwise under stirring, keeping the reaction temperature not exceeding 55 °C, and the reaction was gradually warmed up at this temperature for 6 hours. Upon completion of the reaction, about 600 mL of solvent was removed by distillation. To the residue was added 300 mL of ethyl acetate, the mixture was cooled to 0 °C and stirred for 30 minutes. It was subsequently filtered and the solid was washed with 300 mL of ethyl acetate. The resulting solid was dried to give 1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride (619 g) in 90% yield and 99% HPLC purity.

References

[1] Patent: CN107400087, 2017, A. Location in patent: Paragraph 0045
[2] Patent: WO2011/22596, 2011, A2. Location in patent: Page/Page column 4; 24
[3] Patent: WO2011/22596, 2011, A2. Location in patent: Page/Page column 22; 23
[4] Angewandte Chemie - International Edition, 2013, vol. 52, # 22, p. 5795 - 5798
[5] Angew. Chem., 2013, p. 5999

4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Suppliers

China 138 India 12 United Kingdom 2 United States 5 Global 157

Shanghai Haohong Pharmaceutical Co., Ltd.

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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

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View Lastest Price from 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL manufacturers

Longyan Tianhua Biological Technology Co., Ltd

Product: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL 223251-25-0
Price: US $12.00/Kg/Bag
Min. Order: 25Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-16

Career Henan Chemical Co

Product: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL 223251-25-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: as request
Release date: 2018-12-23

223251-25-0, 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCLRelated Search:

1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE BAZEDOXIFENE ACETATE 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE BenzeneMethanol, 4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]- (hydrochloride) Benzyl chloride

Bazedoxifene intermediate

4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL

1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCI

1H-Azepine, 1-[2-[4-(chloroMethyl)phenoxy]ethyl]hexahydro-, hydrochloride (1:1)

1-[2-[4-(ChloroMethyl)phenoxy]ethyl]hexahydro-1H-azepine hydrochloride

-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL

1-{2-[4-(Chloromethyl)phenoxy]ethyl}azepane hydrochloride (1:1)

1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl

1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane Hydrochloride(For export only)

1-{2-[4-(Chloromethyl)phenoxy]ethyl}azepane hydrochloride (1...

1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochlorideQ: What is 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride Q: What is the CAS Number of 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride Q: What is the storage condition of 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride Q: What are the applications of 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride

1-[2-[4-(chloromethyl)phenoxy]ethyl]hexahydro-1H-Azepine hydrochloride (1:1)

Landiolol Impurity 13 Heoxalate

1-[2-[4-(Chloromethyl)phenoxy]-ethyl]hexahydro-1H-azepine HCl

223251-25-0

C15H22ClNOHCl

Intermediates

223251-25-0