3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE

Product Name: 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE
CAS No.: 198479-63-9
Chemical Name: 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE
Synonyms: 5-(BenzyL;5-(Benzyloxy);oxy)-2-(4-(benzyL;Bazedoxifene Impurity 11;Bazedoxifene intermediate I;3-Methyl-5-(benzyloxy)-2-[4-(benzyloxy)phenyl]indole;3-Methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole;5-(Benzloxy)-2-(4-(Benzyloxy-Phenyl)-3-Methyl-1H-INDOLE;3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-in...;3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE
CBNumber: CB5427501
Molecular Formula: C29H25NO2
Formula Weight: 419.51
MOL File: 198479-63-9.mol

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3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE Property

Melting point:: >143°C (dec.)
Boiling point:: 620.5±55.0 °C(Predicted)
Density: 1.188±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
pka: 16.89±0.30(Predicted)
form: Solid
color: Light Beige
InChI: InChI=1S/C29H25NO2/c1-21-27-18-26(32-20-23-10-6-3-7-11-23)16-17-28(27)30-29(21)24-12-14-25(15-13-24)31-19-22-8-4-2-5-9-22/h2-18,30H,19-20H2,1H3
InChIKey: KRIJKJMYOVWRSJ-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(OCC3=CC=CC=C3)C=C2)C(C)=C1C1=CC=C(OCC2=CC=CC=C2)C=C1

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M326510
Product name: 3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-indole
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 098571
Product name: 5-(Benzyloxy)-2-(4-(benzyloxy)-phenyl)-3-methyl-1H-indole
Purity: 95+%
Packaging: 1g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: J96908
Product name: 5-(Benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole
Packaging: 10g
Price: $340
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 60262
Product name: 3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-indole
Packaging: 250mg
Price: $625
Updated: 2021/12/16

Matrix Scientific

Product number: 098571
Product name: 5-(Benzyloxy)-2-(4-(benzyloxy)-phenyl)-3-methyl-1H-indole
Purity: 95+%
Packaging: 5g
Price: $635
Updated: 2021/12/16

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3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE Chemical Properties,Usage,Production

Uses

3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-indole is an intermediate of Bazedoxifene acetate (B129250).

Synthesis

35081-45-9

51388-20-6

198479-63-9

General procedure for the synthesis of 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole from 4'-benzyloxy-2-bromophenyl acetone and 4-benzyloxyaniline hydrochloride: 10 g of 4'-benzyloxy-2-bromophenyl acetone (II-a), 15 g of p-benzyloxyaniline hydrochloride (II-b), 50 mL of N,N-dimethylformamide and 8 mL of triethylamine were mixed and reacted at 115 °C for 4 hours. Upon completion of the reaction, the progress of the reaction was monitored by thin layer chromatography (TLC). The reaction solution was slowly poured into 250 mL of ice water and a solid was precipitated. The crude product was collected, washed with 20 mL of methanol and dried under vacuum at 40 °C for 24 h. 12.5 g of yellow-brown solid product, 5-benzyloxy-2-[(4-benzyloxy)phenyl]-3-methyl-1H-indole (Intermediate II), was obtained in 94.6% yield.

References

[1] Patent: CN106810487, 2017, A. Location in patent: Paragraph 0078-0083; 0096; 0110; 0117
[2] Patent: CN104098499, 2016, B. Location in patent: Paragraph 0035-0037
[3] Chemico-Biological Interactions, 2012, vol. 197, # 1, p. 8 - 15
[4] Patent: WO2011/22596, 2011, A2. Location in patent: Page/Page column 4; 21; 22
[5] Journal of Medicinal Chemistry, 2001, vol. 44, # 11, p. 1654 - 1657

3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE Suppliers

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View Lastest Price from 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-indole 198479-63-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Longyan Tianhua Biological Technology Co., Ltd

Product: 3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-indole 198479-63-9
Price: US $850.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-16

Career Henan Chemical Co

Product: 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE 198479-63-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: as customer's need
Supply Ability: 1000kg
Release date: 2018-12-19

198479-63-9, 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLERelated Search:

Bazedoxifene Impurity 8 Des(1-azepanyl)ethyl Bazedoxifene 1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepine 3-(4-METHYLBENZYLIDENE)CAMPHOR? Hydrogen BAZEDOXIFENE ACETATE BenzeneMethanol, 4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]- (hydrochloride) 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Bazedoxifene iMpurity 1 Bazedoxifene-d4 Acetate 5-O-Benzylbazedoxifene 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol Bazedoxifene impurity 6 Bazedoxifene impurity 5 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE Bazedoxifene Impurity 10 3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE 2-(4-METHOXYPHENYL)-3-METHYL-5-METHOXYINDOLE

3-METHYL-5-(PHENYLMETHOXY)-2-[4-(PHENYLMETHOXY)PHENYL]-1H-INDOLE

1H-Indole, 3-Methyl-5-(phenylMethoxy)-2-[4-(phenylMethoxy)phenyl]-

Bazedoxifene intermediate I

5-(Benzyloxy)

5-(BenzyL

oxy)-2-(4-(benzyL

Bazedoxifene Impurity 11

5-(Benzloxy)-2-(4-(Benzyloxy-Phenyl)-3-Methyl-1H-INDOLE

3-Methyl-5-(phenylmethoxy)-2-[4-(phenylmethoxy)phenyl]-1H-in...

3-Methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole

3-Methyl-5-(benzyloxy)-2-[4-(benzyloxy)phenyl]indole

198479-63-9

C29H25NO2

Intermediates

198479-63-9