ChemicalBook > CAS DataBase List > 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE

1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE

Product Name
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
CAS No.
66684-61-5
Chemical Name
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
Synonyms
2,4-Difluoro-6-methoxynitrobenzene;1,5-Difluoro-3-Methoxy-2-nitro-benz;1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE;Benzene, 1,5-difluoro-3-Methoxy-2-nitro-;1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE ISO 9001：2015 REACH;3,5-Difluoro-2-nitroanisole【1,5-Difluoro-3-methoxy-2-nitrobenzene】;1,5-Difluoro-3-methoxy-2-nitrobenzene, 3,5-Difluoro-2-nitrophenyl methyl ether
CBNumber
CB02466763
Molecular Formula
C7H5F2NO3
Formula Weight
189.12
MOL File
66684-61-5.mol
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1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE Property

Boiling point:
238℃
Density 
1.414
Flash point:
98℃
storage temp. 
Sealed in dry,Room Temperature
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D451958
Product name
1,5-Difluoro-3-methoxy-2-nitrobenzene
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC7672
Product name
3,5-Difluoro-2-nitroanisole
Packaging
250mg
Price
$18
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-3-76
Product name
3,5-Difluoro-2-nitroanisole
Packaging
250mg
Price
$29
Updated
2021/12/16
Apolloscientific
Product number
PC7672
Product name
3,5-Difluoro-2-nitroanisole
Packaging
1g
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-3-76
Product name
3,5-Difluoro-2-nitroanisole
Packaging
1g
Price
$112
Updated
2021/12/16
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1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE Chemical Properties,Usage,Production

Synthesis

93343-10-3

66684-61-5

1. 3,5-difluoroanisole (30 g, 208 mmol) was dissolved in 260 mL of dichloromethane at 0 °C. 2. Fuming nitric acid (60 mL) at a concentration of greater than 90% was added slowly and dropwise to the above solution. 3. The reaction mixture was kept stirred at 0 °C for 3 h. 4. After completion of the reaction, the reaction mixture was washed with water. 5. The aqueous phase was extracted with dichloromethane. 6. The organic phases were combined and washed with brine, followed by drying with magnesium sulfate.7. The dried organic phase was concentrated on a rotary evaporator.8. The residue was recrystallized by solvent mixing of hexane and ethyl acetate to afford 28.5 g (72% yield) of 1,5-difluoro-3-methoxy-2-nitrobenzene, the product being an off-white powder.1H NMR (400 MHz, DMSO) δ ppm: 7.20 (m, 2H), 3.91 (s, 3H).

References

[1] Patent: US2009/143367, 2009, A1. Location in patent: Page/Page column 30
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7621 - 7638

1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3,5-Difluoro-2-nitroanisole 66684-61-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%+
Supply Ability
100 tons
Release date
2020-01-13
Career Henan Chemical Co
Product
1,5-Difluoro-3-methoxy-2-nitrobenzene 66684-61-5
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

66684-61-5, 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENERelated Search:

p-Anisidine

  • 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
  • 3,5-Difluoro-2-nitroanisole【1,5-Difluoro-3-methoxy-2-nitrobenzene】
  • 2,4-Difluoro-6-methoxynitrobenzene
  • 1,5-Difluoro-3-Methoxy-2-nitro-benz
  • Benzene, 1,5-difluoro-3-Methoxy-2-nitro-
  • 1,5-Difluoro-3-methoxy-2-nitrobenzene, 3,5-Difluoro-2-nitrophenyl methyl ether
  • 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE ISO 9001：2015 REACH
  • 66684-61-5