3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Product Name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- CAS No.
- 877173-84-7
- Chemical Name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Synonyms
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidine, 3-bromo-7-chloro-
- CBNumber
- CB02471468
- Molecular Formula
- C6H3BrClN3
- Formula Weight
- 232.47
- MOL File
- 877173-84-7.mol
3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine Property
- Density
- 2.03
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.91±0.40(Predicted)
- Appearance
- Light yellow to green yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B684358
- Product name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB144101
- Product name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- W9008
- Product name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 250mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- FB144101
- Product name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 118998
- Product name
- 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $216
- Updated
- 2021/12/16
3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine Chemical Properties,Usage,Production
Synthesis
58347-49-2
877173-84-7
The general procedure for the synthesis of 3-bromo-7-chloropyrazolo[1,5-a]pyrimidines using 7-chloropyrazolo[1,5-a]pyrimidines as starting material was as follows: a solution of crude 7-chloropyrazolo[1,5-a]pyrimidines (44.2 g, 289 mmol) was cooled down to 0 °C in dichloromethane (289 mL) in the conditions of an ice bath. N-bromosuccinimide (51.4 g, 289 mmol) was slowly added, followed by stirring the reaction mixture for 16 hours at room temperature. After completion of the reaction, the dark orange reaction solution was diluted with dichloromethane (200 mL) and washed sequentially with 10% potassium carbonate solution (3 x 150 mL) and brine (100 mL). The organic phase was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a dark orange solid. The solid was ground with methanol to afford the target product 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine (50.9 g, 76% yield) as a yellow solid. The product was analyzed by HPLC with a purity of 96%; 1H NMR (250 MHz, CDCl3) δ 8.49 (d, J = 5.2 Hz, 1H), 8.25 (s, 1H), 7.07 (d, J = 5.2 Hz, 1H); 13C NMR (62.9 MHz, DMSO) δ 150.4, 145.9, 144.7, 138.5. 109.5, 84.7.
References
[1] ChemMedChem, 2014, vol. 9, # 11, p. 2516 - 2527
[2] Patent: WO2007/17678, 2007, A1. Location in patent: Page/Page column 44-45
3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine Preparation Products And Raw materials
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