3-BROMO-5-FLUOROBENZALDEHYDE
- Product Name
- 3-BROMO-5-FLUOROBENZALDEHYDE
- CAS No.
- 188813-02-7
- Chemical Name
- 3-BROMO-5-FLUOROBENZALDEHYDE
- Synonyms
- 3-FLUORO-5-BROMOBENZALDEHYDE;3-BROMO-5-FLUOROBENZALDEHYDE;Benzaldehyde, 3-bromo-5-fluoro-;3-Bromo-5-fluorobenzaldehyde98%;3-Bromo-5-fluorobenzaldehyde 98%;3-BROMO-5-FLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB2175256
- Molecular Formula
- C7H4BrFO
- Formula Weight
- 203.01
- MOL File
- 188813-02-7.mol
3-BROMO-5-FLUOROBENZALDEHYDE Property
- Melting point:
- 41-43℃
- Boiling point:
- 231.0±20.0 °C(Predicted)
- Density
- 1.43
- storage temp.
- Inert atmosphere,2-8°C
- form
- Solid
- Appearance
- White to yellow <41°C Solid,>43°C Liquid
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 188813-02-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B686323
- Product name
- 3-Bromo-5-fluorobenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB63996
- Product name
- 3-Bromo-5-fluorobenzaldehyde
- Packaging
- 5G
- Price
- $98
- Updated
- 2021/12/16
- Product number
- HCH0021316
- Product name
- 3-BROMO-5-FLUOROBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $133.35
- Updated
- 2021/12/16
- Product number
- 037416
- Product name
- 3-Bromo-5-fluorobenzaldehyde
- Packaging
- 25g
- Price
- $139
- Updated
- 2021/12/16
- Product number
- PC2392
- Product name
- 3-Bromo-5-fluorobenzaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $179
- Updated
- 2021/12/16
3-BROMO-5-FLUOROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-Bromo-5-fluorobenzaldehyde is an intermediate in organic syntheses. Reatant in the synthesis of 3,4-diamino-3-cyclobutene-1,2-diones, 9,10-Dihydro-9,10-diboraanthracenes.
Synthesis
1435-51-4
68-12-2
188813-02-7
A 2M isopropylmagnesium chloride solution (10 mL, 20 mmol) was dissolved in 5 mL of tetrahydrofuran under ice bath conditions. To this solution was added a tetrahydrofuran solution of 1,3-dibromo-5-fluorobenzene (4.0 g, 15.70 mmol) and the reaction mixture was stirred for 2 hours. The reaction system was then warmed to 20°C and the reaction was continued for 30 minutes. After completion of the reaction, the system was cooled to 0°C, N,N-dimethylformamide (2.5 mL, 31.50 mmol) was slowly added dropwise and the reaction was stirred at this temperature for 1.5 hours. After that, the reaction mixture was stirred at room temperature for 12 hours. At the end of the reaction, the reaction was quenched by adding saturated ammonium chloride solution (20 mL). The reaction mixture was extracted with ethyl acetate (50 mL x 3), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. Purification by silica gel column chromatography using eluent B afforded the target product 3-bromo-5-fluorobenzaldehyde (2.57 g, yellow liquid) in 81.0% yield.
References
[1] Patent: US6355648, 2002, B1. Location in patent: Page column 33-34
[2] Patent: CN103030646, 2016, B. Location in patent: Paragraph 0738; 0740-0743
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 4, p. 818 - 826
[4] Patent: US2007/88053, 2007, A1. Location in patent: Page/Page column 21
[5] Patent: CN105722823, 2016, A. Location in patent: Paragraph 0502; 0503
3-BROMO-5-FLUOROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-5-FLUOROBENZALDEHYDE manufacturers
- Product
- 3-BROMO-5-FLUOROBENZALDEHYDE 188813-02-7
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24